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Bi(glutathion-S-yl)

L-Glutathione Struktur
27025-41-8
CAS-Nr.
27025-41-8
Bezeichnung:
Bi(glutathion-S-yl)
Englisch Name:
L-Glutathione
Synonyma:
GSSG;L-GLUTATHIONE OXIDIZED;GLUTATHIONE DISULFIDE;Oxiglutatione;oxidizedglutathione;L-GLUTATHIONE OXIDISED;GSSC;NOV-002;Glutathiol;oxigluthione
CBNumber:
CB1200803
Summenformel:
C20H32N6O12S2
Molgewicht:
612.63
MOL-Datei:
27025-41-8.mol

Bi(glutathion-S-yl) Eigenschaften

Schmelzpunkt:
178 °C (dec.)(lit.)
alpha 
-99 º (c=4, water)
Dichte
1.3688 (rough estimate)
Brechungsindex
-105 ° (C=2, H2O)
storage temp. 
2-8°C
L?slichkeit
H2O: soluble
Aggregatzustand
powder
pka
2.12, 3.59, 8.75, 9.65(at 25℃)
Farbe
White to off-white
Optische Aktivit?t
-111.016 (H2O)
Wasserl?slichkeit
soluble
Merck 
13,4488
BRN 
1718700
Stabilit?t:
Stable. Incompatible with strong oxidizing agents.
InChIKey
YPZRWBKMTBYPTK-USZNOCQGSA-N
CAS Datenbank
27025-41-8(CAS DataBase Reference)
EPA chemische Informationen
Oxiglutatione (27025-41-8)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xi
R-S?tze: 36/37/38
S-S?tze: 26-36-24/25-36/37/39-27-37/39
WGK Germany  2
RTECS-Nr. MC0556500
HS Code  29309090
Toxizit?t mouse,LD50,intravenous,> 2gm/kg (2000mg/kg),Kiso to Rinsho. Clinical Report. Vol. 23, Pg. 6793, 1989.
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P261 Einatmen von Staub vermeiden.
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P304+P340 BEI EINATMEN: Die Person an die frische Luft bringen und für ungehinderte Atmung sorgen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

Bi(glutathion-S-yl) Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-S?tze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S27:Beschmutzte, getr?nkte Kleidung sofort ausziehen.

Beschreibung

L-Glutathione oxidized(GSSG) is produced by the oxidation of glutathione. Detoxification of reactive oxygen species is accompanied by production of it. It can be used for the research of sickle cells and erythrocytes. The ratio of glutathione (GSH) to oxidised glutathione (GSSG) is a key indicator of cellular oxidative stress. It can be used in the clinical diagnosis and treatment of leukaemia by detecting the level of cellular GSH/GSSG in acute myeloid leukaemia (AML), which is characterised by oxidative stress leading to abnormally low levels of oxidised glutathione, with real-time, dynamic and highly sensitive characteristics[1].

Application

L-Glutathione (GSH) has been used in the elution buffer to elute GST (glutathione S-transferase)-fused proteins using glutathione-agarose beads. It has been used to prepare a standard curve for GSH analyses. May be used at 5-10 mM to elute glutathione S-transferase (GST) from glutathione agarose.

Nebenwirkungen

There have been few studies on the side effects of glutathione use, and as a supplement, no associated side effects have been reported from consuming high glutathione only from diet. However, long-term use of glutathione supplements may reduce zinc levels, and inhaling glutathione can cause breathing problems in some people with mild asthma. In addition, there are concerns that the use of glutathione supplements may cause cramps and bloating or allergic reactions, accompanied by symptoms such as rashes. If you experience any of these side effects, stop taking the supplement and contact your doctor.

l?uterung methode

Purify it by recrystallisation from 50% aqueous EtOH. Its solubility in H2O is 5%. Store it at 4o. [Li et al. J Am Chem Soc 76 225 1954, Berse et al. Can J Chem 37 1733 1959, Beilstein 4 IV 3168.]

Bi(glutathion-S-yl) Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Bi(glutathion-S-yl) Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 522)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hantai Biomedical Group Co. LTD
+8618819265912
id002@cnhantide.com China 37 58
Hebei Shengyang Water Conservancy Engineering Co., Ltd.
+8615373025980
clara@hbshengyang.com China 875 58
Aladdin Scientific
+1-+1(833)-552-7181
sales@aladdinsci.com United States 57505 58
Hebei Weibang Biotechnology Co., Ltd
+8615531157085
abby@weibangbio.com China 8807 58
Hebei Mojin Biotechnology Co., Ltd
+86 13288715578 +8613288715578
sales@hbmojin.com China 12834 58
Shanghai UCHEM Inc.
+862156762820 +86-13564624040
sales@myuchem.com China 7688 58
XI'AN TIANGUANGYUAN BIOTECH CO., LTD.
+86-029-86333380 18829239519
sales06@tgybio.com China 901 58
Hebei Chuanghai Biotechnology Co,.LTD
+86-13131129325
sales1@chuanghaibio.com China 5889 58
henan kanbei chemical co.,ltd
+undefined-86-1523780-4566 +undefined15237804566
henankanbeichemical@163.com China 511 58
Xiamen Wonderful Bio Technology Co., Ltd.
+8613043004613
Sara@xmwonderfulbio.com China 283 58

27025-41-8(Bi(glutathion-S-yl))Verwandte Suche:


  • GAMMA-L-GLUTAMYL-L-CYSTEINYLGLYCINE OXIDIZED
  • (-)-GLUTATHIONE, OXIDIZED
  • GLUTATHIONE, OXIDIZED FORM
  • CYCLIC(GAMMA-GLU-CYS-GLY)
  • CYCLIC(GAMMA-GLU-CYS-GLY)2
  • bi(glutathion-S-yl)
  • GLUTATHIONE OXIDIZED FORM FREE ACID*LYOP HILIZED POW
  • ** APPROVAL REQ **GLUTATHIONE OXIDIZED
  • GLUTATHIONE OXIDIZED FORM FREE ACID*GRAD E II
  • GLUTATHIONE OXIDIZED FORM FREE ACID*SIGM AULTRA
  • L(-)-Glutathione, oxidized, hydrate, 95%
  • Glycine, L-.gamma.-glutamyl-L-cysteinyl-, bimol. (2?2)-disulfide
  • 2-amino-4-[[2-[2-[(4-amino-4-carboxy-butanoyl)amino]-2-(carboxymethylcarbamoyl)ethyl]disulfanyl-1-(carboxymethylcarbamoyl)ethyl]carbamoyl]butanoic acid
  • Glutamine, N,N'-[dithiobis[1-[(carboxymethyl)carbamoyl]ethylene]]di- (7CI)
  • Glutamine, N,N'-[dithiobis[1-[(carboxymethyl)carbamoyl]ethylene]]di-, L- (8CI)
  • Glutathione-S-S-glutathione
  • Glycine, L-g-glutamyl-L-cysteinyl-, bimol. (22')-disulfide (9CI)
  • Oxidized L-glutathione
  • Sleep-promoting factor B
  • NOV-002
  • White lyophilizate
  • L-Glutathione oxidized Vetec(TM) reagent grade, >=98%
  • Glutathione(Oxidized Form), free acid
  • n-(n-gamma-glutamyl-cysteinyl)glycine-(2,2)-disulfide
  • N,N’-[dithiobis[1-[(carboxymethyl)carbamoyl]ethylene]]di-,L-Glutamine
  • n’-(dithiobis(1-((carboxymethyl)carbamoyl)ethylene))di-l-glutamin
  • oxigluthione
  • S,S’-Ethylenebis(glutathione)
  • L-.GLUTATHIONE (OXIDIZED) [N-(N-L-G-GLUTAMYL-L-CYSTEINYL)GLYCINE]
  • GLUTATHIONE OXIDISED extrapure
  • glutathione, oxidised
  • Glutathiol, GSSG
  • L-Glutathione oxidized, Glutathiol, GSSG
  • 3,3'-Dithiobis[N-(carboxymethyl)-N2-(γ-glutamyl)alaninamide]
  • N,N'-Bis(carboxymethyl)-Nα,Nα'-bis(γ-glutamyl)-L-cystinamide
  • Oxyglutatione
  • l-gamma-glutamyl-l-cysteinyl glycine
  • L(-)-Glutathione, oxidized, hydrate,98+%
  • L(-)-Glutathione, oxidized, hydrate,95%
  • L(-)-Glutathione, oxidized,98%
  • L-Glutathione oxidized,GSSG, Glutathiol
  • ()-Glutathione, oxidized,L-Glutathione oxidized, GSSG, Glutathiol
  • Glutathione Oxydized
  • L(-)-Glutathionehydrate
  • L(-)-Glutathione
  • L(-)-Glutathione, oxidized, 98% 500MG
  • N,N'-[Dithiobis[1-[(carboxyMethyl)carbaMoyl]ethylene]]diglutaMine
  • GLT1JP-IN (L-GLUTATHIONE RED
  • Glutathione IMpurity C (Disulfide IMpurity)
  • glutathionedisulphide
  • glutathione-ssg
  • glutathonedisulfide
  • Glycine,L-.gamma.-glutamyl-L-cysteinyl-,2,2’-disulfide
  • glycine,l-gamma-glutamyl-l-cysteinyl-,(2,2’)-disulfide
  • l-oxidizedglutathione
  • N-(N-.gamma.-Glutamyl-cysteinyl)glycine-2,2-disulfide
  • Glutathiol
  • L-GLUTATHIONE (OXIDIZED FORM)
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