Pactamycin Chemische Eigenschaften,Einsatz,Produktion Methoden

Sicherheitsprofil

Poison by ingestion, intravenous, and intraperitoneal routes. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.

Enzyminhibitor

This universal translation inhibitor (FW = 558.63 g/mol; CAS 23668-11-3; soluble in ethanol and benzene; Abbreviation: Pct) from Streptomyces pactum, previously known as NSC 52947 and named systematically as benzoic acid, 2-hydroxy-6-methyl-[(1S,2R,3R,4S,5S)-5-[(3-acetylphenyl) amino]-4-amino-3-[[(dimethylamino)carbonyl]amino]-1,2-dihydroxy-3- [(1S)-1-hydroxyethyl]-2-methylcyclopentyl]methyl ester, inhibits protein synthesis and exhibits antitumor activity. Because the optical rotation of dissolved pactamycin changes upon standing, some as-yet undefined chemical rearrangement must take place. Solutions should be freshly prepared. Primary Mode of Inhibitory Action: Pct restricts structural transitions in ribosomal RNA, preventing the ribosome blocks the binding of initiator tRNA to the initiator complex, preventing formation of the 80S ribosomal complex and arresting protein biosynthesis immediately after the initial dipeptide is formed. Binding Interactions: Pct binds in a single site on the 30S ribosome subunit in the upper part of the platform, very close to the cleft in the subunit that is responsible for binding of the three tRNA molecules. It interacts primarily with residues at the tips of the stem loops H23b and H24a in the central domain of 16S RNA, where it folds up to mimic an RNA dinucleotide. The interaction between N6 of A694 and Pct is crucial for binding of the drug since this is the only interaction with that particular base. N-methylation of this residue causes resistance, most likely from distortions of the local structure

Pactamycin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Pactamycin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	+86-021-61551413 +8618813727289	contact@trustwe.com	China	5738	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32080	58
Zhejiang Huida Biotech Co., LTD	008613515763466 8615669048680	wendy@huidabiotech.com	CHINA	87	58
BOC Sciences	1-631-485-4226; 16314854226	info@bocsci.com	United States	14055	65
T&W GROUP	021-61551611 13296011611	contact@trustwe.com	China	9895	58
ChemStrong Scientific Co.,Ltd	0755-0755-66853366 13670046396	sales@chem-strong.com	China	18043	56
Zhejiang Huida Biotech Co., LTD	0571-89903882 13626641628	jiangnan@huidabiotech.com	China	3656	58
Changzhou Xianglong Pharmaceutical Technology Co., LTD	18661161657	yaoxiangqiu2021@163.com	China	9996	58
Zhejiang Huida Biotech Co., LTD	0571-0571-89903882 15990081639	sunshixuan@huidabiotech.com	China	3705	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	24647	58

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• A 80856F30
• NSC52947
• Pactamycin
• 2-Hydroxy-6-methylbenzoic acid [(1S)-5α-[(3-acetylphenyl)amino]-4β-amino-3β-[[(dimethylamino)carbonyl]amino]-1β,2α-dihydroxy-3-[(S)-1-hydroxyethyl]-2-methylcyclopentyl]methyl ester
• 2-Hydroxy-6-methylbenzoic acid [[(1S)-5α-(3-acetylphenylamino)-4β-amino-3β-(3,3-dimethylureido)-1β,2α-dihydroxy-3-[(S)-1-hydroxyethyl]-2-methylcyclopentan-1α-yl]methyl] ester
• 2-Hydroxy-6-methylbenzoic acid [(1S,2R,3R,4S,5S)-5-[(3-acetylphenyl)amino]-4-amino-3-[[(dimethylamino)carbonyl]amino]-1,2-dihydroxy-3-[(1S)-1-hydroxyethyl]-2-methylcyclopentyl]methyl ester
• PNU-0015800
• U-15800
• Benzoic acid, 2-hydroxy-6-methyl-, [(1S,2R,3R,4S,5S)-5-[(3-acetylphenyl)amino]-4-amino-3-[[(dimethylamino)carbonyl]amino]-1,2-dihydroxy-3-[(1S)-1-hydroxyethyl]-2-methylcyclopentyl]methyl ester
• 23668-11-3