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Rutamycin

Rutamycin Struktur
1404-59-7
CAS-Nr.
1404-59-7
Englisch Name:
Rutamycin
Synonyma:
A-272;RR-32705;Rutamycin;RRNo-32705;oligomycin D;26-Demethyloligomycin A;RutaMycin, 26-deMethyloligoMycin A, A 272, RR 32705, RutaMycin A;Spiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2'-[2H]pyran]-3,9,13-trione,22-ethyl-3',4',5',6'-tetrahydro-7,11,14,15-tetrahydroxy-6'-[(2R)-2-hydroxypropyl]-5',6,8,10,12,14,16,29-octamethyl-,(1S,2'R,4E,5'S,6S,6'S,7S,8S,10R,11R,12S,14R,15S,16R,18E,20E,22R,25S,29R)-;Spiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2'-[2H]pyran]-3,9,13-trione, 22-ethyl-3',4',5',6'-tetrahydro-7,11,14,15-tetrahydroxy-6'-[(2R)-2-hydroxypropyl]-5',6,8,10,12,14,16,29-octamethyl-, (1S,2'R,4E,5'S,6S,6'S,7R,8S,10R,11R,12S,14R,15S,16R,18E,20E,22R,25S,29R)-
CBNumber:
CB11120704
Summenformel:
C44H72O11
Molgewicht:
777.042
MOL-Datei:
1404-59-7.mol

Rutamycin Eigenschaften

Schmelzpunkt:
116-119°
alpha 
D20 -62° (c = 1.36 in CHCl3)
Siedepunkt:
883.4±65.0 °C(Predicted)
Dichte
1.15±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
L?slichkeit
DMF: soluble; DMSO: soluble; Ethanol: soluble; Methanol: soluble
Aggregatzustand
A lyophilisate
pka
12.52±0.70(Predicted)

Sicherheit

RIDADR  2811
HazardClass  6.1(b)
PackingGroup  III
Toxizit?t LD50 oral in mouse: 800mg/kg

Rutamycin Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Oligomycin D is a macrolide antibiotic produced by several species of Streptomyces that inhibits the mitochondrial F1FO-ATPase and is used to uncouple oxidative phosphorylation from electron transport. Oligomycin D is reported to inhibit K-Ras plasma membrane localization in MDCK cells with an IC50 value of 3.49 nM and is cytotoxic to SW620 colon cancer cells with an IC50 value of 36 μM.

Verwenden

Oligomycin D (rutamycin) is macrocyclic lactone belonging to the oligomycin class but identified from different species of Streptomyces in 1961. Like oligomycin A, oligomycin D inhibits mitochondrial F1F0-ATPase and is an important bioprobe to study the organisation of ATPase on the mitochondrial membrane. Oligomycin D exhibits a broad biological profile including antifungal, antitumor and nematocidal activities.

Rutamycin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Rutamycin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 38)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 32161 58
Career Henan Chemica Co 		+86-0371-86658258 +8613203830695
 laboratory@coreychem.com China 30238 58
BOC Sciences 		16314854226; +16314854226
 inquiry@bocsci.com United States 19741 58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		+86-057181025280; +8617767106207
 sales@molcore.com China 49734 58
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd 		+86-18791163155 +86-13119157289
 13119157289@163.com China 2973 58
Lynnchem 86-(0)29-85992781 17792393971
 info@lynnchem.com China 4587 58
Novachemistry 44-20819178-90 02081917890
 info@novachemistry.com United Kingdom 4381 58
Shanghai Hongye Biotechnology Co. Ltd 400-9205774
sales@glpbio.cn China 6777 58
Shenzhen Polymeri Biochemical Technology Co., Ltd. +86-400-002-6226 +86-13028896684;
 sales@rrkchem.com China 57423 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767
 sales@chemegen.com China 11218 58

1404-59-7()Verwandte Suche:

  • 26-Demethyloligomycin A
  • A-272
  • RR-32705
  • RRNo-32705
  • RutaMycin, 26-deMethyloligoMycin A, A 272, RR 32705, RutaMycin A
  • Rutamycin
  • oligomycin D
  • Spiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2'-[2H]pyran]-3,9,13-trione,22-ethyl-3',4',5',6'-tetrahydro-7,11,14,15-tetrahydroxy-6'-[(2R)-2-hydroxypropyl]-5',6,8,10,12,14,16,29-octamethyl-,(1S,2'R,4E,5'S,6S,6'S,7S,8S,10R,11R,12S,14R,15S,16R,18E,20E,22R,25S,29R)-
  • Spiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2'-[2H]pyran]-3,9,13-trione, 22-ethyl-3',4',5',6'-tetrahydro-7,11,14,15-tetrahydroxy-6'-[(2R)-2-hydroxypropyl]-5',6,8,10,12,14,16,29-octamethyl-, (1S,2'R,4E,5'S,6S,6'S,7R,8S,10R,11R,12S,14R,15S,16R,18E,20E,22R,25S,29R)-
  • 1404-59-7
  • C44H72O11
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