Palifosfamide
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- CAS-Nr.
- 31645-39-3
- Englisch Name:
- Palifosfamide
- Synonyma:
- Ipam;ZIO-201;Nsc 297900;ZIO-201, >98%;palifosfamide;Ifosforamide mustard;Isophosphamide mustard;Palifosfamide (ZIO-201);Abbreviation: IPM-lysine;isophosphoramide mustard-lysine
- CBNumber:
- CB11011411
- Summenformel:
- C4H11Cl2N2O2P
- Molgewicht:
- 221.02
- MOL-Datei:
- 31645-39-3.mol
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Palifosfamide Eigenschaften
- Schmelzpunkt:
- 106-107 ºC
- Siedepunkt:
- 341.5±52.0 °C(Predicted)
- Dichte
- 1.411
- storage temp.
- Store at -20°C, protect from light, stored under nitrogen
- L?slichkeit
- ≥22.1 mg/mL in DMSO; insoluble in EtOH; ≥19.4 mg/mL in H2O with gentle warming and ultrasonic
- Aggregatzustand
- Powder
- pka
- 0.79±0.50(Predicted)
- Farbe
- White to off-white
- InChI
- InChI=1S/C4H11Cl2N2O2P/c5-1-3-7-11(9,10)8-4-2-6/h1-4H2,(H3,7,8,9,10)
- InChIKey
- BKCJZNIZRWYHBN-UHFFFAOYSA-N
- SMILES
- P(NCCCl)(NCCCl)(O)=O
- CAS Datenbank
- 31645-39-3
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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Palifosfamide Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Palifosfamide is an active metabolite of the DNA alkylating agent ifosfamide. It is formed through hydroxylation of ifosfamide by various hepatic cytochrome P450 (CYP) isoforms. It is cytotoxic to L1210 and CCRF-CEM cancer cells when used at a concentration of 100 μM. Palifosfamide (100 mg/kg per day) reduces tumor growth in murine Lewis lung carcinoma and L1210 leukemia models, as well as a rat Yoshida ascitic sarcoma model.
Definition
ChEBI: Palifosfamide, also known as Isophosphamide mustard, is a type of phosphorodiamide. It is a proprietary stabilized metabolite of ifosfamide. Ifosfamide has been shown to be effective in high doses in treating testicular cancer, sarcoma and lymphoma.
Mode of action
Palifosfamide works by irreversibly alkylating and cross-linking DNA through GC base pairs, leading to 7-atom inter-strand cross-links that cannot be repaired. Its cytotoxic effect primarily stems from its ability to cross-link strands of DNA and RNA, inhibit protein synthesis, and block DNA replication, ultimately causing cell death. Unlike ifosfamide, this agent is not metabolized to acrolein or chloroacetaldehyde, metabolites associated with bladder and CNS toxicities.
Palifosfamide Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Palifosfamide Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 85)Lieferanten
31645-39-3()Verwandte Suche:
- Ifosforamide mustard
- Ipam
- N,N'-Di-(2-chloroethyl)phosphorodiamidic acid
- N,N'-BIS(2-CHLOROETHYL)PHOSPHORODIAMIDATE
- Isophosphamide mustard
- palifosfamide
- N,N'-Bis(2-chloroethyl)phosphorodiamidic acid
- N1,N2-Bis(2-chloroethyl)phosphoric acid diamide
- Nsc 297900
- ZIO-201
- ZIO-201, >98%
- Abbreviation: IPM-lysine
- isophosphoramide mustard-lysine
- ISOPHOSPHORAMIDE MUSTARD-LYSINE;ABBREVIATION: IPM-LYSINE;ZIO-201.
- Palifosfamide (ZIO-201)
- ZIO 201,inhibit,Palifosfamide,ZIO201,DNA Alkylator/Crosslinker,Inhibitor,Drug Metabolite,IPM
- 31645-39-3
- C4H11Cl2N2O2P
