CGP 55845 Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
CGP is a potent, selectie GABAB receptor antagonist.
Biologische Aktivit?t
Potent, selective GABA B receptor antagonist (IC 50 = 5 nM) that prevents agonist binding (pK i = 8.35) and inhibits GABA and glutamate release (pEC 50 values are 8.08 and 7.85 respectively). Inhibits GABA B responses to baclofen (IC 50 = 130 nM in an isoproterenol assay) and potentiates the hypoglycemic response to glucose in vitro .
Biochem/physiol Actions
CGP 55845 is a potent selective GABA-B receptor antagonist with an IC50 of 5 nM.
CGP 55845 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
