2-(1,5-DIMETHYL-3-OXO-2-PHENYL-2,3-DIHYDRO-1H-PYRAZOL-4-YL)-1,3-DIOXOISOINDOLINE-5-CARBOXYLIC ACID
CAS-Nr.
292870-53-2
Englisch Name:
2-(1,5-DIMETHYL-3-OXO-2-PHENYL-2,3-DIHYDRO-1H-PYRAZOL-4-YL)-1,3-DIOXOISOINDOLINE-5-CARBOXYLIC ACID
Synonyma:
BV02;TOSLAB 796846;BV02 >=98% (HPLC);2-(1,5-DIMETHYL-3-OXO-2-PHENYL-2,3-DIHYDRO-1H-PYRAZOL-4-YL)-1,3-DIOXOISOINDOLINE-5-CARBOXYLIC ACID;2-(2,3-Dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)-2,3-dihydro-1,3-dioxo-1H-isoindole-5-carboxylic acid;2-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carboxylic acid;1H-Isoindole-5-carboxylic acid, 2-(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)-2,3-dihydro-1,3-dioxo-
CBNumber:
CB0712242
Summenformel:
C20H15N3O5
Molgewicht:
377.35
MOL-Datei:
Mol file
2-(1,5-DIMETHYL-3-OXO-2-PHENYL-2,3-DIHYDRO-1H-PYRAZOL-4-YL)-1,3-DIOXOISOINDOLINE-5-CARBOXYLIC ACID Eigenschaften
Siedepunkt:
593.8±60.0 °C(Predicted)
Dichte
1.512±0.06 g/cm3(Predicted)
storage temp.
room temp
L?slichkeit
DMSO: >5mg/mL
pka
3.39±0.20(Predicted)
Aggregatzustand
powder
Farbe
white to off-white
Sicherheit
Risiko- und Sicherheitserkl?rung
Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher
N
R-S?tze:
50
S-S?tze:
61
RIDADR
UN 3077 9 / PGIII
WGK Germany
3
Bildanzeige (GHS)
Alarmwort
Warnung
Gefahrenhinweise
Code
Gefahrenhinweise
Gefahrenklasse
Abteilung
Alarmwort
Symbol
P-Code
H400
Sehr giftig für Wasserorganismen.
Kurzfristig (akut) gew?ssergef?hrdend
Kategorie 1
Warnung
src="/GHS09.jpg" width="20" height="20" />
P273, P391, P501
Sicherheit
P273
Freisetzung in die Umwelt vermeiden.
2-(1,5-DIMETHYL-3-OXO-2-PHENYL-2,3-DIHYDRO-1H-PYRAZOL-4-YL)-1,3-DIOXOISOINDOLINE-5-CARBOXYLIC ACID Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
BV02 has been used to study the effects of 14-3-3σ on P-glycoprotein and pregnane X receptor protein xpression. It has also been used as a control in studying BAP1 (BRCA1 (breast cancer gene)-associated protein 1) inducing cell death via interaction with 14-3-3 in neuroblastoma.
Biochem/physiol Actions
BV02 is an inhibitor of the 14-3-3 scaffolding proteins docking site. BV02 promotes the apoptotic death of cells expressing either wt Bcr-Abl construct or T315I mutation. It induces apoptosis by c-Abl release from 14-3-3? and re-location to nuclear compartment and at mitochondrial membranes.
2-(1,5-DIMETHYL-3-OXO-2-PHENYL-2,3-DIHYDRO-1H-PYRAZOL-4-YL)-1,3-DIOXOISOINDOLINE-5-CARBOXYLIC ACID Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
2-(1,5-DIMETHYL-3-OXO-2-PHENYL-2,3-DIHYDRO-1H-PYRAZOL-4-YL)-1,3-DIOXOISOINDOLINE-5-CARBOXYLIC ACID Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 18)Lieferanten
China 10
Finland 2
Russia 2
The Netherlands 1
United States 3
Global 18
TOSLAB 796846
2-(1,5-DIMETHYL-3-OXO-2-PHENYL-2,3-DIHYDRO-1H-PYRAZOL-4-YL)-1,3-DIOXOISOINDOLINE-5-CARBOXYLIC ACID
2-(2,3-Dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)-2,3-dihydro-1,3-dioxo-1H-isoindole-5-carboxylic acid
BV02
2-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carboxylic acid
BV02 >=98% (HPLC)
1H-Isoindole-5-carboxylic acid, 2-(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)-2,3-dihydro-1,3-dioxo-
292870-53-2