2-(5-Methoxyindol-3-yl)ethylamin

608-07-1

CAS-Nr.: 608-07-1

Bezeichnung:: 2-(5-Methoxyindol-3-yl)ethylamin

Englisch Name:: 5-Methoxytryptamine

Synonyma:: 5-Methoxyindoleacetate;Methoxytryptamine;2-(5-METHOXY-1H-INDOL-3-YL)ETHANAMINE;Melatonin Related CoMpound A;2-(5-methoxy-1H-indol-3-yl)acetic acid;MEXAMINE;MEXAMINE HYDROCHLORIDE;5-METHOXYTRYPTAMINE HCL;2-(5-methoxyindol-3-yl)ethylamine;5MOT

CBNumber:: CB0676885

Summenformel:: C11H14N2O

Molgewicht:: 190.24

MOL-Datei:: 608-07-1.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 503

2-(5-Methoxyindol-3-yl)ethylamin Eigenschaften

Schmelzpunkt:: 121-123 °C (lit.)

Siedepunkt:: 325.75°C (rough estimate)

Dichte: 1.0815 (rough estimate)

Brechungsindex: 1.5700 (estimate)

storage temp.: 2-8°C

L?slichkeit: Chloroform (Slightly), Methanol (Slightly)

Aggregatzustand: crystalline

pka: 16.91±0.30(Predicted)

Farbe: white

Merck: 13,6032

BRN: 145587

InChI: InChI=1S/C11H14N2O/c1-14-9-2-3-11-10(6-9)8(4-5-12)7-13-11/h2-3,6-7,13H,4-5,12H2,1H3

InChIKey: JTEJPPKMYBDEMY-UHFFFAOYSA-N

SMILES: N1C2=C(C=C(OC)C=C2)C(CCN)=C1

CAS Datenbank: 608-07-1(CAS DataBase Reference)

NIST chemische Informationen: 5-Methoxytryptamine(608-07-1)

Sicherheit

Risiko- und Sicherheitserkl?rung
Gefahreninformationscode (GHS)

Kennzeichnung gef?hrlicher	Xn
R-S?tze:	22-36/37/38-20/21/22
S-S?tze:	36-26
WGK Germany	3
RTECS-Nr.	NL4110000
F	8
HS Code	29339900
Toxizit?t	LD50 intraperitoneal in mouse: 176mg/kg

Bildanzeige (GHS)

Alarmwort

Warnung

Gefahrenhinweise

Code	Gefahrenhinweise	Gefahrenklasse	Abteilung	Alarmwort	Symbol	P-Code
H302	Gesundheitssch?dlich bei Verschlucken.	Akute Toxizit?t oral	Kategorie 4	Warnung	src="/GHS07.jpg" width="20" height="20" />	P264, P270, P301+P312, P330, P501

Sicherheit

2-(5-Methoxyindol-3-yl)ethylamin Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R22:Gesundheitssch?dlich beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R20/21/22:Gesundheitssch?dlich beim Einatmen,Verschlucken und Berührung mit der Haut.

S-S?tze Betriebsanweisung:

S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.

Beschreibung

5-Methoxytryptamine (5-MT), also known as mexamine, is a tryptamine derivative closely related to the neurotransmitters serotonin and melatonin. 5-MT has been shown to occur naturally in the body in low levels.It is biosynthesized via the deacetylation of melatonin in the pineal gland.
The protective effect of 5-methoxytryptamine (a metabolite of melatonin) in human keratinocytes against ultraviolet B (UVB) radiation was studied.
Melatonin and its metabolites ameliorate ultraviolet B-induced damage in human epidermal keratinocytes.

Chemische Eigenschaften

White to tan crystalline powder

Verwenden

5-Methoxytryptamine (Mexamine, Methoxytryptamine) is a tryptamine derivative that is closely related to the neurotransmitter Melatonin (M215000) and Serotonin (S274980). It acts as a full agonist at the 5-HT1, 5-HT2, 5-HT4, 5-HT6, and 5-HT7 receptors but has no affinity for the 5-HT3 receptor.

Application

5-Methoxytryptamine was used as an agonist in the study of pharmacological profile of the 5-hydroxytryptamine 1 receptor.
Reactant for preparation of:
Carboline disaccharide domain of shishijimicin A
Melatonin analogs for the reduction of intraocular pressure
5-HT4 receptor ligands
inhibitors of sortase A and isocitrate lyase
Therapeutic agents for treatment of ischemia/reperfusion (I/R) injury
Aurora and epidermal growth factor receptor kinase inhibitors
Agents for the treatment of human papillomavirus infection
Manzamine analogues for the control of neuroinflammation and cerebral infections
Inhibitors of pro-inflammatory cytokines
Tacrine-melatonin hybrids as multifunctional agents for alzheimer′s disease

Definition

ChEBI: 5-methoxytryptamine is a member of the class of tryptamines that is the methyl ether derivative of serotonin. It has a role as a serotonergic agonist, a human metabolite, a mouse metabolite, a 5-hydroxytryptamine 2A receptor agonist, a 5-hydroxytryptamine 2C receptor agonist, a 5-hydroxytryptamine 2B receptor agonist, an antioxidant, a radiation protective agent, a neuroprotective agent and a cardioprotective agent. It is a member of tryptamines, an aromatic ether and a primary amino compound. It derives from a serotonin. It is a conjugate base of a 5-methoxytryptamine(1+).

Allgemeine Beschreibung

The protective effect of 5-methoxytryptamine (a metabolite of melatonin) in human keratinocytes against ultraviolet B (UVB) radiation was studied.

2-(5-Methoxyindol-3-yl)ethylamin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

2,3,4,9-Tetrahydro-6-methoxy-1H-pyrido[3,4-b]indol-1-on 6-METHOXY-1,2,3,4-TETRAHYDRO-BETA-CARBOLINE 6-methoxy-1-phenyl-2,3,4,9-tetrahydro-1H-beta-carboline 6-METHOXY-1 2 3 4-TETRAHYDRO-9H-PYRIDO-& N-(2-nitrophenyl)-5-methoxytryptamine N-[2-(5-Methoxy-1H-indole-3-yl)ethyl]-2-chloroacetamide N-(2-(5-Methoxyindol-3-yl)ethyl)acetamid

2-(5-Methoxyindol-3-yl)ethylamin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

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608-07-1(2-(5-Methoxyindol-3-yl)ethylamin)Verwandte Suche:

5-Methoxy-1H-indol-3-ethylaminmonohydrochlorid N-(2-(5-Methoxyindol-3-yl)ethyl)acetamid (Trifluormethoxy)benzol Anisol Anisaldehyd Methoxyammoniumchlorid p-(Chlormethyl)anisol 4-Methoxyphenylaceton Serotonin hydrochloride 4-Methoxy-anilin 3-(METHOXYMETHOXY)BENZALDEHYDE 2-(2-Aminoethyl)-5-methoxyindol 5-Benzyloxy-DL-tryptophan 12-Methoxyibogaminmonohydrochlorid 5-Benzyloxy-3-(2-ethylamino)indolhydrochlorid Indol-5-ylmethylether DL-5-Methoxytryptophan 5-Methoxy-N,N-dimethyl-1H-indol-3-ethylamin

1H-Indole-3-ethanamine, 5-methoxy-
3-(2-aminoethyl)-5-methoxy-indol
5-methoxy-1h-indole-3-ethanamin
5MOT
Ethanamine,2-(5-methoxy-3-indolyl)-
Indole, 3-(2-aminoethyl)-5-methoxy-
Meksamin (free base)
Mexamine base
ART-CHEM-BB B028531
AURORA KA-7772
BIO-FARMA BF000967
METHOXYTRYPTAMINE, 5-
5-METHOXYTRYPTAMINE FREE BASE
5-METHOXY-TRYPTAMIN
2-[5-(Methyloxy)-1H-indol-3-yl]ethanaMine
3-(2-Aminoethyl)-5-methoxyindole O-Methylserotonin
TIMTEC-BB SBB003309
RARECHEM AL BW 2333
O-METHYLSEROTONIN
O-METHYLSEROTONIN HYDROCHLORIDE
5 - Methoxyl priMary aMine
5-METHOXYTRYPTAMINE
AKOS JY2083095
AKOS B028531
AKOS BB-5620
2-[5-METHOXYINDOL-3-YL]ETHYLAMINE HYDROCHLORIDE
2-(5-METHOXY-1H-INDOL-3-YL)ETHANAMINE HYDROCHLORIDE
2-(5-METHOXY-1H-INDOL-3-YL)-ETHYLAMINE
3-(2-AMINOETHYL)-5-METHOXYINDOLE
5-METHOXYTRYPTAMINE 98+%
Methyl sulfone(MSM)
3-(2-Aminoethyl)-5-methoxyindole, 5-Methoxytryptamine, Mexamine
5-Methoxy-1H-indole-3-ethan-1-amine
5-METHOXYTRYPTAMINE(5MeOTry)
5-Methoxytryptamine,97%
3-(Aminoethyl)-5-methoxyindole
5-Methoxy-[1H]-indole-3-ethanamine
Meksamin
5-Methoxyindole-3-ethanamine
NSC 56422
2-(5-methoxy-1H-indol-3-yl)ethanamine(SALTDATA: HCl)
5-MethyltrptaMine
2-(5-Methoxy-1H-indol-3-yl)ethylamine, 5-Methoxytryptamine
3-(2-Aminoethyl)-5-methoxy-1H-indole
Melatonin Related Compound A (15 mg) (2-(5-methoxy-1H-indol-3-yl)ethanamine)
Deacetylmelatonin
EOS-62441
2-(5-Methoxy-1H-indol-3-yl)ethanami
5-Methoxy-3-indoleaceate
Melatonin USP Related Compound A
Melatonin USP RC A
Melatonin Impurity 1 (Melatonin USP Related Compound A)
5-Methoxytryptamine ISO 9001：2015 REACH
Melatonin Related Compound A (N-Desacetyl Melatonin/ 5-Methoxytryptamine)
Melatonin Related Compound A (2-(5-methoxy-1H-indol-3-yl)ethanamine) (1380116)
Methoxytryptamine
2-(5-methoxyindol-3-yl)ethylamine
MEXAMINE

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