YW1128 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

YW1128 is an inhibitor of Wnt/β-catenin signaling with an IC₅₀ value of 4.1 nM in a reporter assay. It decreases protein levels of β-catenin in the presence of the GSK3β inhibitor lithium chloride and increases protein levels of Axin1 in HEK293 cells. YW1128 decreases lipid accumulation and the expression of gluconeogenic and lipogenic genes in Huh7 cells. It decreases the hepatic expression of Wnt target genes, improves glucose tolerance, and prevents body weight increases and hepatic lipid accumulation in mice fed a high-fat diet, but not mice fed normal chow, when administered at a dose of 40 mg/kg every other day for 11 weeks.

YW1128 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

YW1128 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32161	58
BOC Sciences	16314854226	info@bocsci.com	United States	9923	65
Shanghai Hongye Biotechnology Co. Ltd	400-9205774	sales@glpbio.cn	China	6777	58
DC Chemicals	021-58447131 13564518121	sales@dcchemicals.com	China	9409	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11218	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	24644	58
Shanghai Yifei Biotechnology Co. , Ltd.	021-65675885 18964387627	customer_service@efebio.com	China	11974	58
RD International Technology Co., Limited	18024082417	market@ubiochem.com	China	9266	58

---

• 3-triazole-4-carboxamide
• 5-methyl-1-(2-methylphenyl)-N-2-quinolinyl-1H-1
• 5-METHYL-1-(2-METHYLPHENYL)-N-2-QUINOLINYL-1H-1;2;3-TRIAZOLE-4-CARBOXAMIDE
• YW1128
• 1H-1,2,3-Triazole-4-carboxamide, 5-methyl-1-(2-methylphenyl)-N-2-quinolinyl-
• YW1128,YW-1128
• 2131223-64-6