4-(3'-Methylphenyl)amino-3-pyridinesulfonamide
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- CAS-Nr.
- 72811-73-5
- Englisch Name:
- 4-(3'-Methylphenyl)amino-3-pyridinesulfonamide
- Synonyma:
- BM 960102;Torsemide Imp B;TORSEMIDE EP IMP B;4-(3'-Methylphenyl)a;TorseMide IMpurity B;SPECS AJ-333/25006115;Torasemide intermediate;Torsemide EP Impurity B;Torasemide EP Impurity B;Torasemide impurity B (EP)
- CBNumber:
- CB0486466
- Summenformel:
- C12H13N3O2S
- Molgewicht:
- 263.32
- MOL-Datei:
- 72811-73-5.mol
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4-(3'-Methylphenyl)amino-3-pyridinesulfonamide Eigenschaften
- Schmelzpunkt:
- 162-164?C
- Siedepunkt:
- 475.8±55.0 °C(Predicted)
- Dichte
- 1.357±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- L?slichkeit
- DMSO (Slightly), Methanol (Slightly)
- pka
- 9.53±0.60(Predicted)
- Farbe
- White to Off-White
- BRN
- 5438165
- InChIKey
- ZXPCUGWAKUIOOF-UHFFFAOYSA-N
- CAS Datenbank
- 72811-73-5(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
Xi |
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| R-S?tze: |
36 |
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| S-S?tze: |
26 |
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| HS Code |
2935909550 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
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| Sicherheit |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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4-(3'-Methylphenyl)amino-3-pyridinesulfonamide Chemische Eigenschaften,Einsatz,Produktion Methoden
Chemische Eigenschaften
White to Off-White Solid
Verwenden
Torasemide intermediate.
Synthese
4-(3'-Methylphenyl)amino-3-pyridinesulfonamide is prepared by the reaction of 4-Chloropyridine-3-sulfonamide hydrochloride and 3-Methylaniline. The specific synthesis steps are as follows:
EXAMPLE 1; Preparation of 4-(3-methylphenyl)aminopyridine-sulfonamide; 2L three-neck flask, equipped with a mechanical stirrer, thermometer and condenser, was charged with water (500 ml) and 4-chloro-3- pyridinesulfonamide hydrochloride (100g, 0.44 mol). To this suspension was added m-toluidine (49.2 ml, 0.46 mol) at room temperature. The reaction mixture was heated to 90°C for a minimum period of 3 h. The progress of the reaction was followed by HPLC. After completion, the mixture was cooled to room temperature. The pH of the reaction was then adjusted carefully to pH 7-8 with sat. NaHC03 (ca. 1.1 l). The product was precipitated out and isolated by vacuum filtration as beige solid (126.2 g wet weight). The product was then dissolved in MeOH (1.0 l) at room temperature and charged with Darco KB (25g). The solution was refluxed for 0.5 h and then filtered through a patch of celite to remove Darco KB, while still hot, and rinsed with hot MeOH (200 ML). The filtrate was then charged with water (1.2 l) and stirred for a minimum of 1 h at room temperature. The product, which had precipitated out, was isolated by vacuum filtration to obtain a solid 106.3 g (92percent wet weight =>99.8percent purity a/a). 1H NMR (d6-DMSO) ; 2.30 (s, 3H), 7.00-7. 15 (m. 5H), 7.32 (m, 1H), 7.75 (brs, 1.5H), 8.05 (brs, 0.5H), 8.25 (d, 1H), 8.68 (s, 1H).
4-(3'-Methylphenyl)amino-3-pyridinesulfonamide Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
4-(3'-Methylphenyl)amino-3-pyridinesulfonamide Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 327)Lieferanten
72811-73-5()Verwandte Suche:
- 4-(-3-METHYLPHENYL)AMINO-3-PYRIDINESULFONAMIDE
- 4-(3'-METHYLPHENYL)AMINO-3-PYRIDINESULFONAMIDE
- 3-SULFONAMIDO-4-(3-METHYLANILINO)-PYRIDINE
- SPECS AJ-333/25006115
- 4-(3-METHYLPHENYL)AMINO-3-PYRIDINESULFONAMIDE (SMPAP)
- 4-[3-Methyl phenyl] amino-3-pyridine sulphonamide
- Torasemide intermediate
- [4-(3-Methylphenyl)amino]pyrid
- 4-(3-methylphenyl)amino-3-pyridine sulfonamide (intermediate of torasemide)
- 4-(3-methylphenylamino) Pyridine-3-sulfonamide
- [4-3-Methylphenyl)amino]pyridine-3-sulphonamide
- 4-(3-METHYLPHENYL)AMINO-3-PYRIDINESULFONAMIDE 98%
- 4-(3'-Methylphenyl)a
- TorseMide Related CoMpound A
- BM 960102
- 4-(M-TolylaMino)pyridine-3-sulfonaMide
- TorseMide IMpurity B
- Standard for Torasemide Impurity
- Torasemide Impurity 2（Torasemide EP Impurity B）
- Torasemide EP Impurity B
- Torasemide impurity B (EP)
- 4-[(3-Methylphenyl)amino]-pyridin-3-sulfonamide
- Torsemide USP Related Compound A
- Torasemi Impurity B Standard
- 4[(3-Methyl Phenyl) amino] 3-Pyridine Sulfonamide (Torsamide Intermediate) (72811-73-5)
- 4-[(3-Methylphenyl)amino]pyridine-3
- 3-Pyridinesulfonamide, 4-[(3-methylphenyl)amino]-
- Torsemide EP Impurity B
- 4-(3-Methylphenyl)amino-3-sulfamoylpyridine
- 4-(m-Tolylamino)-3-sulfamoylpyridine
- 4-(3'-Methylphenyl)amino-3-pyridinesulfonamide ISO 9001：2015 REACH
- Torsemide EP Impurity B/ Torsemide Related Compound A
- TIANFU-CHEM_high purity of 4-(3'-Methylphenyl)amino-3-pyridinesulfonamide
- Torsemide Impurity BQ: What is
Torsemide Impurity B Q: What is the CAS Number of
Torsemide Impurity B Q: What is the storage condition of
Torsemide Impurity B Q: What are the applications of
Torsemide Impurity B
- 4-(3-methylanilinopyridine)-3-sulfonamide
- Torasemide, Anhydrous Impurity B
- Torasemide, Anhydrous EP Impurity B
- 4-(3-Methylphenyl)Amino-3-Pyridinesulfonamide
(Torsemide Intermediate)
- Torsemide Imp B
- 4-(3'-Methylphenyl)amino-3-pyridinesulfonamide
- TORSEMIDE EP IMP B
- Torasemide (Torsemide) EP Impurity B (Torasemide (Torsemide) USP Related Compound A)
- 72811-73-5
- C12H13N3O2S
- Aromatics
- Intermediates & Fine Chemicals
- Pharmaceuticals
- INTERMEDIATESOFTORASEMIDE
- Pyridines derivates
- (intermediate of torasemide)
- Pyridines
- Torsemide
- 72811-73-5
