MS023 (hydrochloride) Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

MS023 is an inhibitor of type I protein arginine methyltransferases (PRMTs; IC₅₀s = 30, 119, 83, 4, and 5 nM for PRMT1, -3, -4, -6, and -8, respectively). It is selective for these type I PRMTs over PRMT5, -7, and -9, as well as a panel of 25 protein lysine methyltransferases (PKMTs) and DNA methyltransferases (DNMTs) when used at a concentration of 10 μM. It inhibits the methylation of histone 4 at arginine 3 (H4R3) in MCF-7 breast cancer cells (IC₅₀ = 9 nM) and H3R2 in HEK293 cells (IC₅₀ = 56 nM). MS023 (20 μM) also inhibits the methylation of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleocapsid protein and the replication of SARS-CoV-2 in Vero E6 cells. It reduces tumor growth in a Huh7 mouse xenograft model when administered at a dose of 160 mg/kg.

MS023 (hydrochloride) Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

MS023 (hydrochloride) Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9806	58
DC Chemicals	021-58447131 13564518121	sales@dcchemicals.com	China	9409	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11217	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	24647	58
Nanjing Tengyi Biotechnology Co., Ltd	025-58851786 17714337195	sales@tybiochem.com	China	6813	58
Deyang Sino Biotech. Co., LTD	+86-19182167371 +86-19182167371	service@synlord.com	China	99	58

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• MS023 (hydrochloride)
• N1-methyl-N1-[[4-[4-(1-methylethoxy)phenyl]-1H-pyrrol-3-yl]methyl]-1,2-ethanediamine,trihydrochloride
• MS023 trihydrochloride
• 2108631-19-0