Parthenolide
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Parthenolide Eigenschaften
- Schmelzpunkt:
- 115-116 °C (lit.)
- alpha
- D20 -81.4° (c = 1.04 in chloroform); D22 -71.4° (c = 0.220 in CH2Cl2)
- Siedepunkt:
- 394.1±42.0 °C(Predicted)
- Dichte
- 1.13±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- L?slichkeit
- Soluble in DMSO (up to 100 mg/ml) or in Ethanol (up to 20 mg/ml)
- Aggregatzustand
- White solid
- Farbe
- White
- Merck
- 14,7048
- Stabilit?t:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
- InChI
- InChI=1S/C15H20O3/c1-9-5-4-8-15(3)13(18-15)12-11(7-6-9)10(2)14(16)17-12/h5,11-13H,2,4,6-8H2,1,3H3/b9-5+/t11-,12-,13+,15+/m0/s1
- InChIKey
- KTEXNACQROZXEV-PVLRGYAZSA-N
- SMILES
- O1C(=O)C(=C)[C@]2([H])CCC(C)=CCC[C@@]3(C)O[C@]3([H])[C@@]12[H] |t:10|
- LogP
- 2.424 (est)
- CAS Datenbank
- 20554-84-1
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher | Xi,C,F | ||
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R-S?tze: | 11-34 | ||
S-S?tze: | 22-24/25-45-36/37/39-26-16 | ||
WGK Germany | 3 | ||
RTECS-Nr. | LY4220000 | ||
HS Code | 29322090 |
Bildanzeige (GHS) |
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Parthenolide Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R11:Leichtentzündlich.R34:Verursacht Ver?tzungen.
S-S?tze Betriebsanweisung:
S22:Staub nicht einatmen.S24/25:Berührung mit den Augen und der Haut vermeiden.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S16:Von Zündquellen fernhalten - Nicht rauchen.
Beschreibung
(-)-Parthenolide (PTL) is a natural sesquiterpene lactone produced as a secondary metabolite by plants of the Asteraceae/ Compositae (daisies) and Magnoliaceae family (magnolias). It was first isolated from feverfew (Tanacetum parthenium L. Schulz Bip. or synonymously Chrysanthemum parthenium L. Bernh.). The plant owes its name to its use as a long known natural remedy for alleviating fever, migraine, rheumatoid arthritis, stomach ache, toothache, and insect bites, among other ailments. After it was shown that parthenolide is the main biologically active ingredient of these plant(s)1b, many studies have described promising anti-inflammatory and anti-tumour properties of the natural product. Interestingly, it was shown that PTL was cytotoxic to tumor cells while almost not affecting healthy cells at similar concentrations. Moreover, it was reported to be one of the few small molecules that selectively target cancer stem cells, which are still difficult to treat and a suspected reason for tumour relapse[6].Chemische Eigenschaften
White solidVerwenden
Parthenolide is a sesquiterpene lactone from the plant feverfew (T. parthenium). It inhibits the growth of the promastigote form of L. amazonensis (IC50 = 3.6 μg/ml). Parthenolide also induces apoptosis in cancer cells, at least in part by inhibiting NF-κB- and STAT-mediated anti-apoptotic gene transcription. This compound has also been shown to block inflammation by inhibiting signaling through NF-κB. Inhibition of NF-κB by parthenolide can be achieved by direct binding of the pattern recognition receptor NOD2 by parthenolide.Definition
ChEBI: Parthenolide is a sesquiterpene lactone and active principle of Feverfew (Tanacetum parthenium). It has a role as a non-steroidal anti-inflammatory drug, a non-narcotic analgesic, a peripheral nervous system drug, an inhibitor and a drug allergen.Allgemeine Beschreibung
This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KGBiologische Aktivit?t
The active principle of feverfew (Chrysanthemum parthenium), widely used as a herbal remedy for arthritis and migraine and as a febrifuge. Parthenolide is antisecretory, anti-inflammatory, spasmolytic and inhibits the release of 5-HT from blood platelets. Also inhibits generation of leukotriene B 4 and thromboxane B 2 .Kontakt-Allergie
Parthenolide is a sesquiterpene lactone found Asteraceae- Compositae such as feverfew (Tanacetum parthenium Schultz-Bip.) or congress grass (Parthenium hysterophorus L.).Parthenolide Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Parthenolide Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 433)Lieferanten
Firmenname | Telefon | Land | Produktkatalog | Edge Rate | |
---|---|---|---|---|---|
Accendatech Co., Ltd. | +8613132578992 |
yunhao.liu@accendatech.com | China | 251 | 58 |
Hebei Chuanghai Biotechnology Co., Ltd | +86-15531157085; +8615531157085 |
abby@chuanghaibio.com | China | 8808 | 58 |
Hebei Mujin Biotechnology Co.,Ltd | +86 13288715578 +8613288715578 |
sales@hbmojin.com | China | 12796 | 58 |
Hebei Kingfiner Technology Development Co.Ltd | +86-15532196582 +86-15373005021 |
lisa@kingfinertech.com | China | 3005 | 58 |
Shaanxi Haibo Biotechnology Co., Ltd | +undefined18602966907 |
qinhe02@xaltbio.com | China | 997 | 58 |
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 |
info@fdachem.com | China | 20232 | 58 |
Shanghai Zheyan Biotech Co., Ltd. | 18017610038 |
zheyansh@163.com | CHINA | 3619 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29856 | 58 |
Biochempartner | 0086-13720134139 |
candy@biochempartner.com | CHINA | 965 | 58 |
Jinan Jianfeng Chemical Co., Ltd | +86-0531-88110457 +86-15562555968 |
info@pharmachemm.com | China | 333 | 58 |
20554-84-1()Verwandte Suche:
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Dihydro-4-methyl-5-pentylfuran-2(3H)-on
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FEVERFEW
(E)-5-Decenylacetat
- [1aR-(1aR*,4E,7aS*,10aS*,-10bR*)]-2,3-6,7,7a,8,10a,10b-Octahydro-1a,5-dimethyl-8-methyleneoxireno[9,10]cyclodeca[1,2-b]furan-9(1aH)-one
- (1aR,4E,7aS,10aS,10bS)-2,3,6,7,7a,8,10a,10b-Octahydro-1a,5-dimethyl-8-methyleneoxireno[9,10]cyclodeca[1,2-b]furan-9(1aH)-one
- 4,5α-Epoxy-6β-hydroxygermacra-1(10),11(13)-dien-12-oic acid γ-lactone
- 4,5alpha-epoxy-6beta-hydroxy-germacra-1(10),11(13)-dien-12-oic acid gamma-lactone
- Germacra-1(10),11(13)-dien-12-oic acid, 4,5-alpha-epoxy-6-beta-hydroxy-, gamma-lactone
- Parthenolide
- Parthenolide ((-)-Parthenolide)
- PartheNAlide
- Aids007764
- Aids-007764
- Nsc157035
- Oxireno[9,10]cyclodeca[1,2-B]furan-9(1ah)-one, 2,3,6,7,7A,8,10A,10B-octahydro-1A,5-dimethyl-8-methylene-, (1ar,4E,7as,10as,10bs)-
- Parthenolides
- Parthelide
- Parthenolide (25 mg)
- Oxireno(9,10)cyclodeca(1,2-B)furan-9(1ah)-o
- Parthenolide, froM ChrysantheMuM MorifoliuM
- (3aS,9aR,10aS,10bS,E)-6,9a-dimethyl-3-methylene-3a,4,5,8,9,9a,10a,10b-octahydrooxireno[2',3':9,10]cyclodeca[1,2-b]furan-2(3H)-one
- PTL
- Parthenolide(PTL)
- [1AR-(1AR*,4E,7AS*,10AS*-10BR*)]-2,3-6,7,7A,8,10A,10B-OCTAHYDRO-1A,5-DIMETHYL-8-METHYLENEOXIRENO[9,10]CYCLODECA[1,2-B]FURAN-9(1AH)-ONE
- PARTHENOLIDE, TANACETUM PARTHENIUM
- 4,5-alpha-epoxy-6-beta-hydroxy-11(13)-dien-12-oicacigamma-germacra-1(10
- 4,5-alpha-epoxy-6-beta-hydroxygermacra-1(10),11(13)-dien-12-oicacidgamma-la
- Parthenolide from Chrysanthenum parthenium
- Oxireno9,10cyclodeca1,2-bfuran-9(1aH)-one, 2,3,6,7,7a,8,10a,10b-octahydro-1a,5-dimethyl-8-methylene-, (1aR,4E,7aS,10aS,10bR)-
- Parthenolide, Tanacetum parthenium - CAS 20554-84-1 - Calbiochem
- Factory Price Parthenolide 20554-84-1
- Natural Plant Extracts Parthenolide 20554-84-1 High Purity HPLC>98%
- Feverfew P.E Parthenlide
- Parthenolide, 98%, from Chrysanthemum morifolium
- Parthenolide>
- (-)-Parthenolide
- PARTHENOLIDE, DIMETHYLAMINOPARTHENOLIDE
- parthenolider
- Chrysanthemum lactone
- Autophagy,inhibit,Parthenolide,Nuclear factor-kappaB,Mitochondrial Autophagy,NF-κB,Nuclear factor-κB,Apoptosis,Inhibitor,Mitophagy
- (3aS,9aR,10aR,10bS,E)-6,9a-Dimethyl-3-methylene-3a,4,5,8,9,9a,10a,10b-octahydrooxireno[2',3':9,10]cyclodeca[1,2-b]furan-2(3H)-one
- Parthenolide-RM
- Parthenolide, 10 mM in DMSO
- Parthenolide, Tanacetum parthenium
- Chrysanthemum parthenium extracts
- (1aR,4E,7aS,10aS,10bR)-2,3,6,7,7a,8,10a,10b-Octahydro-1a,5-dimethyl-8-methyleneoxireno[9,10]cyclodeca[1,2-b]furan-9(1aH)-one
- (3aS,9aR,10aR,10bS,E)-6,9a-Dimethyl-3-methylene-3a,4,5,8,9,9a,10a,10b-octahydrooxireno[2',3':9,10]cyclodeca[1,2-b]furan-2(3H)-one
- 20554-84-1
- 20552-41-8
- 10-21-7
- Anti-Proliferative Agents
- Antitumor Agents
- BioChemical
- Cancer Research
- inhibitor
- chemical reagent
- pharmaceutical intermediate
- phytochemical
- reference standards from Chinese medicinal herbs (TCM).
- standardized herbal extract
- Natural Product