Cianidanol
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Cianidanol Eigenschaften
- Schmelzpunkt:
- 175-177 °C (anhydrous)(lit.)
- Siedepunkt:
- 352.36°C (rough estimate)
- alpha
- D18 +16 to +18.4°
- Dichte
- 1.2451 (rough estimate)
- Brechungsindex
- 1.4359 (estimate)
- storage temp.
- 2-8°C
- L?slichkeit
- DMSO (Slightly), Methanol (Slightly), Water (Slightly, Sonicated, Heated)
- Aggregatzustand
- Solid
- pka
- 9.54±0.10(Predicted)
- Farbe
- Light Orange to Light Brown
- Merck
- 14,1902
- InChIKey
- PFTAWBLQPZVEMU-DZGCQCFKSA-N
- LogP
- 0.510
- CAS Datenbank
- 154-23-4
- EPA chemische Informationen
- 2H-1-Benzopyran-3,5,7-triol, 2-(3,4-dihydroxyphenyl)-3,4-dihydro-, (2R,3S)- (154-23-4)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher | Xi | ||
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R-S?tze: | 36/37/38 | ||
S-S?tze: | 26-36 | ||
WGK Germany | 3 | ||
RTECS-Nr. | DJ3450000 | ||
F | 8-10-23 | ||
HS Code | 29329990 | ||
Toxizit?t | LD50 oral in rat: > 10gm/kg |
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Sicherheit |
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Cianidanol Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
Tan SolidVerwenden
Cianidanol, also known as (+)-catechin; (+)-3,3′4′,5,7-flavanepentol; 3,3′,4′, 5,7-pentahydroxyflavane, [R,3S]-2-[3,4-dihydroxyphenyl]-3,4-dihydro-1[2H]- benzopyran-3,4,7-triol, or 2-(3,4-dihydroxyphenyl)-3,4-dihydro-(2r-trans)-2h- 1-benzopyran-7-triol, is a flavonoid associated with a variety of blood disorders. An association of cianidanol and immune hemolytic anemia and thrombocytopenia has been suggested in numerous case reports. In several reports, the presence of flavonoid-dependent antibodies against red blood cells is evident with cianidanol combining with erythrocyte membranes and inducing development of autoantibodies and antibodies.Several patients had platelet antibodies with increased serum-bindable IgG values without the presence of cianidanol and several with high platelet-associated IgG levels.Antibodies against cianidanol were not detectable in certain cases.The hemolytic anemia caused acute renal failure in some patients and can be life threatening, leading to fatalities. Upon cessation of treatment with cianidanol, hematology appears to return to normal over time.These side effects do not appear to be specific to cianidanol as the formation of IgE and IgG antibodies to troxerutin (Venoruton) and silymarin (Kegalon) was also evident with patients presenting with fever, skin eruptions, and intravascular hemolysis often demonstrating high IgG titers.Furthermore, cianidanol-induced hemolysis might also occur after sensitization by other flavonoids including rutin.
Definition
ChEBI: The (+)-enantiomer of catechin and a polyphenolic antioxidant plant metabolite.Weltgesundheitsorganisation (WHO)
Cianidanol, which is extracted from the tropical plant Uncaria gambir, was introduced in 1976 as an adjunct in the treatment of liver disorders. Following a cluster of cases of haemolytic anaemia reported in 1985 from Naples, Italy, four of which were fatal, the company suspended sales worldwide. Although subsequently reintroduced in Switzerland and France for the treatment of acute and chronic hepatitis-B, it was later definitively withdrawn in Switzerland on detailed reassessment and the manufacturer has now withdrawn the product worldwide.Allgemeine Beschreibung
(+)-Catechin is an important beneficial compound, belonging to the flavonoid class, which is present abundantly in red wine.Cianidanol Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Cianidanol Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 371)Lieferanten
Firmenname | Telefon | Land | Produktkatalog | Edge Rate | |
---|---|---|---|---|---|
Hebei Kingfiner Technology Development Co.Ltd | +86-15532196582 +86-15373005021 |
lisa@kingfinertech.com | China | 3009 | 58 |
Hebei Saisier Technology Co., LTD | +86-18400010335 +86-18034520335 |
admin@hbsaisier.cn | China | 1015 | 58 |
Hebei Longbang Technology Co., LTD | +86-18633929156 +86-18633929156 |
admin@hblongbang.com | China | 941 | 58 |
HebeiShuoshengImportandExportco.,Ltd | +86-18532138899 +86-18532138899 |
L18532138899@163.com | China | 939 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21634 | 55 |
Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 |
product@chemlin.com.cn | CHINA | 3009 | 60 |
Shanghai Zheyan Biotech Co., Ltd. | 18017610038 |
zheyansh@163.com | CHINA | 3619 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29880 | 58 |
SHANDONG ZHI SHANG CHEMICAL CO.LTD | +86 18953170293 |
sales@sdzschem.com | China | 2930 | 58 |
Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 |
sales@biopurify.com | China | 3772 | 58 |
154-23-4(Cianidanol)Verwandte Suche:
Biphenyl-2-ol
Tetrahydro-4H-pyran-4-on
Hydroxy silicone oil
1,2-Dihydroxybenzol
Tetrahydropyran
Triphenylphosphin
(2S-trans)-2-(3,4-Dihydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-3,5,7-triol
Silicristin
trans-2-(3,4-Dihydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-3,5,7-triol
Silibinin
2-(3,4-Dihydroxyphenyl)-2,3,4-trihydro-3,5,7-trihydroxychromen
(-)-Epigallocatechin
Phenylaceton
Cianidanol
benzopyran
- (+)-CATECHIN
- CATECHIN, (+)-
- (+)-3,3'4',5,7-FLAVANEPENTOL
- 3,3',4',5,7-PENTAHYDROXYFLAVANE
- [2R,3S]-2-[3,4-DIHYDROXYPHENYL]-3,4-DIHYDRO-1[2H]-BENZOPYRAN-3,4,7-TRIOL
- 2-(3,4-dihydroxyphenyl)-3,4-dihydro-(2r-trans)-2h-1-benzopyran-7-triol
- 5,7-triol,2-(3,4-dihydroxyphenyl)-3,4-dihydro-,(2R-trans)-2H-1-Benzopyran-3
- catechin(flavan)
- catechinicacid
- catechol(flavan)
- catechuicacid
- catergen
- cianidanol
- d-catechol
- kb-53
- 2-(3,4-dihydroxyphenyl)chromane-3,5,7-triol (2R,3S)
- (2R,3S)-2-(3,4-dihydroxyphenyl)chroman-3,5,7-triol
- CATECHIN 85%
- (2R,3S)-2-(3,4-Dihydroxyphenyl)-3,4-dihydro-2H-chromene-3,5,7-triol
- (+)-CATECHIN WITH HPLC
- 2H-1-Benzopyran-3,5,7-triol,2-(3,4-dihydroxyphenyl)-3,4-dihydro-, (2R,3S)-
- Catechin,Cianidanol,Cyanidol
- (+)-Cyanidan-3-ol
- 2H-1-Benzopyran-3,5,7-triol, 2-(3,4-dihydroxyphenyl)-3,4-dihydro-, (2R-trans)-
- Cyanidanol
- CATECHIN, (+)-(AHP)(CALL)
- (2R,3S)-2-(3,4-Dihydroxyphenyl)-3,4-dihydro-1(2H)-benzopyra3,5,7-triol
- (+)-Catechin, froM green tea
- (+)-Catechin (25 mg)
- Catechin(C)
- (2R,3S)-
- (+)-Catechin-d3
- Biocatechin
- Cianidanol, Dexcyanidanol
- Drenoliver
- Tanningenic acid
- Cianidanol,(+)-Catechin hydrate
- Cianidanol(EGCG)
- (+)-Cyanidol-3 (2R,3S)-2-(3,4-Dihydroxyphenyl)-3,4-dihydro-1(2H)-benzopyra3,5,7-triol
- (+)-Catechin 154-23-4
- (+)-Catechin, 99%, from green tea
- (+)-Catechin Standard
- (+)-Catechin Hydrate>
- Cianidanol Solution, 100μg/mL
- Cianidanol USP/EP/BP
- (+)-catechin
- (+)-Catechin (1096790)
- CATECHIN
- D-CATECHIN
- (2R,3S)-2-(3,4-dihydroxyphenyl)chromane-3,5,7-triol
- Cianidano
- Catechine
- (+)-Catechin C
- (+)-Catechin (25 mg)
- (+)-Catechin-RM
- 154-23-4
- 15-23-4
- Flavonoids