4-amino-5-ethylsulfonyl-2-methoxy-N-[[1-(1,1,2,2,2-pentadeuterioethyl)pyrrolidin-2-yl]methyl]benzamide Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Amisulpride-d₅ is intended for use as an internal standard for the quantification of amisulpride by GC- or LC-MS. Amisulpride is a dopamine D₂ and D₃ receptor antagonist (K_is = 3 and 3.5 nM, respectively). It is also an antagonist of the serotonin (5-HT) receptor subtypes 5-HT_2B, 5-HT₇, and 5-HT_7A (K_is = 13, 11.5, and 135.5 nM, respectively). It is selective for these receptors over a panel of 39 additional receptors, ion channels, and transporters (K_is = >1,000 nM for all). Amisulpride increases 7-OH-DPAT-induced decreases in dopamine and acetylcholine release in electrically stimulated rat striatal slices (EC₅₀s = 2.2 and 1.2 nM, respectively). It increases the levels of dopamine and the dopamine metabolite 3,4-dihydroxyphenylacetic acid (DOPAC) in rat striatum and nucleus accumbens when administered intraperitoneally at a dose of 10 mg/kg. Amisulpride decreases immobility time in the forced swim test in rats, as well as reduces stress-induced decreases in sucrose consumption in a rat model of depression induced by chronic mild stress.

4-amino-5-ethylsulfonyl-2-methoxy-N-[[1-(1,1,2,2,2-pentadeuterioethyl)pyrrolidin-2-yl]methyl]benzamide Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

4-amino-5-ethylsulfonyl-2-methoxy-N-[[1-(1,1,2,2,2-pentadeuterioethyl)pyrrolidin-2-yl]methyl]benzamide Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
TargetMol Chemicals Inc.		support@targetmol.com	United States	38470	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	57505	58
Nanjing XiZe Biotechnology CO., Ltd.	025-66023220 0086-15250997978	1511893459@qq.com	China	7850	55
Artis Biotech Co. Ltd.	0575-18780151478 18582380095	sales@artisbio.com	China	2964	58
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9806	58
Hubei Yangxin Medical Technology Co., Ltd.	15374522761	3003392093@qq.com	China	8376	55
Tianjin shijia biomedical technology co., LTD	15022261580	tjshj1212@163.com	China	2510	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11217	58
ShangHai Anpel Co, Ltd.	18501792038; 18501792038	shanpel@anpel.com.cn	China	9611	58
SHENZHEN PHYSTANDARD BIO-TECH CO.,LTD	0755-0755-0755-83725350 13380397412	3001280422@qq.com	China	10005	58

1216626-17-3()Verwandte Suche:

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