Roscovitine
|
|
- CAS-Nr.
- 186692-46-6
- Englisch Name:
- Roscovitine
- Synonyma:
- Seliciclib;Roscovitin;Roscovitine (Seliciclib,CYC202);CYC 202;Posiphe;CS-1845;P34 CDC2;ROSCOVITINE;Roscoviline;(R)-2-(1-ETHY
- CBNumber:
- CB0367185
- Summenformel:
- C19H26N6O
- Molgewicht:
- 354.45
- MOL-Datei:
- 186692-46-6.mol
|
Roscovitine Eigenschaften
- Schmelzpunkt:
- 106~107℃
- Siedepunkt:
- 577.5±60.0 °C(Predicted)
- Dichte
- 1.3
- storage temp.
- -20°C
- L?slichkeit
- Soluble in DMSO (up to 10 mg/ml, with warming) or in Ethanol (up to 10 mg/ml).
- Aggregatzustand
- White to off-white solid
- pka
- 14.56±0.10(Predicted)
- Farbe
- White
- Stabilit?t:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
- InChIKey
- BTIHMVBBUGXLCJ-OAHLLOKOSA-N
- CAS Datenbank
- 186692-46-6(CAS DataBase Reference)
Roscovitine Chemische Eigenschaften,Einsatz,Produktion Methoden
S-S?tze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Definition
ChEBI: 2,6-Diaminopurine carrying benzylamino, (2R)-1-hydroxybutan-2-yl and isopropyl substituents at C-6, C-2-N and N-9 respectively. It is an experimental drug candidate in the family of pharmacological cyclin-dependent kinase (CDK) inhibitors.
Allgemeine Beschreibung
A potent, reversible, and selective inhibitor of cyclin-dependent kinases (Cdks) that exhibits about ten-fold greater efficacy towards p34
cdk1 and p33
cdk2 and twenty-fold greater efficacy towards p33
cdk5 relative to Olomoucine (Cat. No.
495620). Inhibits p34
cdk1/cyclin B (IC
50 = 650 nM), p33
cdk2/cyclin A (IC
50 = 700 nM), p33
cdk2/cyclin E (IC
50 = 700 nM), and p33
cdk5/p35 (IC
50 = 200 nM) by competing for the ATP binding domain of the kinases. Exhibits reduced sensitivity towards related kinases including ERK1 and ERK2 (IC
50 = 34 μM and 14 μM, respectively). Roscovitine does not significantly affect the activity of other protein kinases even at 100 μM, including p34
cdk4/cyclin D1 and p40
cdk6/cyclin D2. Compared to olomoucine, roscovitine displays increased anti-mitotic activity at the G
1/S and G
2/M phases of the cell cycle. A 50 mM (5 mg/282 μl) solution of Roscovitine (Cat. No.
557364) in DMSO is also available.
Anticancer Research
Roscovitine a derivative of olomoucine which is isolated from Raphanus sativus isunder clinical trials (Shoeb 2006).
Roscovitine Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Roscovitine Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 225)Lieferanten
- 2-(R)-[[9-(1-Methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-1-butanol, 6-(Benzylamino)-2(R)-[[1-(hydroxymethyl)propyl]amino]-9-isopropylpurine
- (2R)-2-[[6-(benzylamino)-9-propan-2-yl-purin-2-yl]amino]butan-1-ol
- 2-(R)-(1-ETHYL-2-HYDROXYETHYLAMINO)-6-BENZYLAMINO-9-ISOPROPYLPURINE
- 2-(1-ETHYL-2-HYDROXYETHYLAMINO)-6-BENZYLAMINO-9-ISOPROPYLPURINE
- 6-BENZYLAMINO-2-(R)-[(1-ETHYL)-2-HYDROXYETHYLAMINO]-9-ISOPROPYLPURINE
- ROSCOVITINE
- (R)-ROSCOVITINE
- (R)-2-(1-ETHYL-2-HYDROXYETHYLAMINO)-6-BENZYLAMINO-9-ISOPROPYLPURINE
- P34 CDC2
- R-ROSCOVITINE 98% (HPLC)
- ROSCOVITINE 95+%
- 1-Butanol, 2-[[9-(1-methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-, (2R)-
- 2-(r)-[[9-(1-methylethyl)-6-[(phenylmethyl)amino]-9h-purin-2-yl]amino]-1-butanol
- 6-(Benzylamino)-2(R)-[[1-(hydroxymethyl)propyl]amino]-9-isopropylpurine
- Roscovitine (CYC202,Seliciclib)
- 6-Benzylamino-2[(R)-(1'-ethyl-2'-hydroxyethylamino)]-9-isopropylpurine Roscovitine
- Roscovitine,2-(R)-[[9-(1-Methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-1-butanol, 6-(Benzylamino)-2(R)-[[1-(hydroxymethyl)propyl]amino]-9-isopropylpurine
- Roscovitine(CYC202)
- 2-[[9-(1-Methylethyl)-6-[(phenylMethyl)aMino]-9H-purin-2-yl]aMino]-
- (R)-2-(1-ETHY
- Roscovitine (Seliciclib)
- (2R)-2-[[9-(1-Methylethyl)-6-[(phenylMethyl)aMino]-9H-purin-2-yl]aMino]-1-butanol
- (R)-2-[[9-(1-Methylethyl)-6-[(phenylMethyl)aMino]-9H-purin-2-yl]aMino]-1-butanol
- CYC 202
- Roscoviline
- Posiphe
- CYC-202(ROSCOVITINE)
- 6-(Benzylamino)-2(R)-[[1-(hydroxymethyl)propyl]amino]-9-isopropylpurine Roscovitine
- 6-(Benzylamino)-2(R)-[[1-(hydroxymethyl)propyl]amino]-9-isopropylpurine Roscovitine (Seliciclib,CYC202)
- Roscovitine
(R)-Roscovitine
- Roscovitine, >=98%
- Roscovitine - CAS 186692-46-6 - Calbiochem
- CS-1845
- SELICICLIB (ROSCOVITINE)
- CYC202;R-ROSCOVITINE;SELICICLIB
- 2-(6-Benzylamino-9-isopropyl-9H-purin-2-ylamino)-butan-1-ol (CYC202)
- ROSCOVITINE USP/EP/BP
- Seliciclib-d7
- Seliciclib
- Roscovitin
- Roscovitine (Seliciclib,CYC202)
- 186692-46-6
- Cell Signaling and Neuroscience
- Cell Cycle
- Cell Cycle Regulators
- Cell Biology
- BioChemical
- Apoptosis and Cell Cycle
- Inhibitors
- Apis
- API intermediates