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Gusacitinib

Gusacitinib Struktur
1425381-60-7
CAS-Nr.
1425381-60-7
Englisch Name:
Gusacitinib
Synonyma:
ASN-002;GUSACITINIB;GUSACITINIB (ASN-002);ASN-002 (Gusacitinib;Gusacitinib, 10 mM in DMSO;Syk,Janus kinase,Gusacitinib,Spleen tyrosine kinase,JAK,ASN 002,ASN002,Inhibitor,inhibit;1-[5,6-Dihydro-4-[[4-(4-hydroxy-1-piperidinyl)phenyl]amino]-5-oxopyrimido[4,5-d]pyridazin-2-yl]-4-piperidineacetonitrile;4-Piperidineacetonitrile, 1-[5,6-dihydro-4-[[4-(4-hydroxy-1-piperidinyl)phenyl]amino]-5-oxopyrimido[4,5-d]pyridazin-2-yl]-;2-(1-(4-((4-(4-hydroxypiperidin-1-yl)phenyl)amino)-5-oxo-5,6-dihydropyrimido[4,5-d]pyridazin-2-yl)piperidin-4-yl)acetonitrile
CBNumber:
CB03364604
Summenformel:
C24H28N8O2
Molgewicht:
460.53
MOL-Datei:
1425381-60-7.mol

Gusacitinib Eigenschaften

Dichte
1.47±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
L?slichkeit
DMSO:100.0(Max Conc. mg/mL);217.14(Max Conc. mM)
Aggregatzustand
A crystalline solid
pka
9.17±0.20(Predicted)
Farbe
Light yellow to yellow
InChIKey
NLFLXLJXEIUQDL-UHFFFAOYSA-N
SMILES
N1(C2=NC(NC3=CC=C(N4CCC(O)CC4)C=C3)=C3C(=O)NN=CC3=N2)CCC(CC#N)CC1

Sicherheit

Gusacitinib Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Gusacitinib is an orally bioavailable, potent dual inhibitor of Janus kinases (JAK 1, 2, 3, and TYK2) and spleen tyrosine kinase (SYK) with 50% inhibitory concentrations (IC50 values) of 5 to 46 nM in biochemical assays. Gusacitinib targets both Th1 and Th2 inflammatory pathways, which are involved in CHE[1].

Trademarks

ASN-002, EN-3351

Einzelnachweise

[1] Pablo A. Jimenez MD . “Oral spleen tyrosine kinase/Janus Kinase inhibitor gusacitinib for the treatment of chronic hand eczema: Results of a randomized phase 2 study.” Journal of the American Academy of Dermatology 89 2 (2023): Pages 235-242.

Gusacitinib Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Gusacitinib Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 52)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Wuhan Jingkang en Biomedical Technology Co., Ltd
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 orders@jknbiochem.com China 5221 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
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Aladdin Scientific 		+1-+1(833)-552-7181
sales@aladdinsci.com United States 57505 58
Kaixin Chemical (Hong Kong) Limited 010-88886666-01 13112345678
 loyson@tcypharm.com China 595 55
Shanghai Taibao Pharmaceutical Technology Co., Ltd. 13816752554
 1745533547@qq.com China 129 58
Wuhan Jingkangen Biomedical Technology Co., Ltd 13720134139 13720134139
 orders@jknbiochem.com China 5825 58
  • ASN-002
  • GUSACITINIB (ASN-002)
  • 1-[5,6-Dihydro-4-[[4-(4-hydroxy-1-piperidinyl)phenyl]amino]-5-oxopyrimido[4,5-d]pyridazin-2-yl]-4-piperidineacetonitrile
  • GUSACITINIB
  • 2-(1-(4-((4-(4-hydroxypiperidin-1-yl)phenyl)amino)-5-oxo-5,6-dihydropyrimido[4,5-d]pyridazin-2-yl)piperidin-4-yl)acetonitrile
  • ASN-002 (Gusacitinib
  • 4-Piperidineacetonitrile, 1-[5,6-dihydro-4-[[4-(4-hydroxy-1-piperidinyl)phenyl]amino]-5-oxopyrimido[4,5-d]pyridazin-2-yl]-
  • Syk,Janus kinase,Gusacitinib,Spleen tyrosine kinase,JAK,ASN 002,ASN002,Inhibitor,inhibit
  • Gusacitinib, 10 mM in DMSO
  • 1425381-60-7
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