Diethylaminomalonathydrochlorid
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- CAS-Nr.
- 13433-00-6
- Bezeichnung:
- Diethylaminomalonathydrochlorid
- Englisch Name:
- Diethyl aminomalonate hydrochloride
- Synonyma:
- Diethyl 2-aminomalonate;DIETHYL 2-AMINOMALONATE HYDROCHLORIDE;Aminomalonamid;aminomalonate hydrochloride;diethyl 2-aminopropanedioate;AminomaL;onate HydrochL;Diethyl aminomalonat;Amoxapine Impurity 6;Amoxapine Impurity 2 HCl
- CBNumber:
- CB0325376
- Summenformel:
- C7H14ClNO4
- Molgewicht:
- 211.64
- MOL-Datei:
- 13433-00-6.mol
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Diethylaminomalonathydrochlorid Eigenschaften
- Schmelzpunkt:
- 165-170 °C (dec.)(lit.)
- storage temp.
- Inert atmosphere,2-8°C
- L?slichkeit
- Chloroform, DMSO, Water
- Aggregatzustand
- Crystalline Powder
- Farbe
- White to slightly yellow
- Wasserl?slichkeit
- soluble
- Sensitive
- Hygroscopic
- BRN
- 3568037
- InChIKey
- GLFVNTDRBTZJIY-UHFFFAOYSA-N
- CAS Datenbank
- 13433-00-6(CAS DataBase Reference)
Diethylaminomalonathydrochlorid Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
white to slightly yellow crystalline powder
Verwenden
Diethyl aminomalonate hydrochloride is used as a pharmaceutical intermediate. Diethyl aminomalonate with formaldehyde generates an azomethine ylide which can undergo cycloadditions with 1,2-dipolarophiles to form pyrrolidines.
Synthese
A solution of 420.0 g of a mixture of diethyl hydroxyiminomalonate and diethyl acetoxyiminomalonate (together 2.0 mol) in 400 ml of ethyl acetate, 40.0 g of anhydrous magnesium sulfate and 12.5 g of palladium on activated charcoal (5 percent by weight of Pd) as hydrogenation catalyst were placed in a 1.5 l pressure reactor equipped with a stirrer. At 30° to 35° C., hydrogen was introduced under a pressure of 20 bar for 80 minutes until the pressure remained constant. The reactor contents were thoroughly mixed by stirring during this process. The hydrogenation mixture was cooled to 20° C. and diluted with 200 ml of ethyl acetate and the mixture of hydrous magnesium sulfate and catalyst was filtered off. The solid which had been separated off was washed three times with a total of 200 ml of ethyl acetate and the wash liquor was combined with the filtrate. Diethyl aminomalonate hydrochloride was precipitated out as a white solid by the introduction of 68 g of dry hydrogen chloride, filtered off, washed with ethyl acetate and dried under a water jet vacuum at 70° C. The yield was 359.6 g (85.1% of theory), the melting point was 165° C. and the purity according to the analytically determined chlorine content was 100%.
Diethylaminomalonathydrochlorid Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Diethylaminomalonathydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 550)Lieferanten
13433-00-6(Diethylaminomalonathydrochlorid)Verwandte Suche:
- AMino Malonic diethyl ester hydrochloride
- Diethyl 2-aminopropanedioate hydrochloride
- 1,3-diethyl 2-aminopropanedioate, HCl
- Diethyl aMinoMalonate hydrochloride (AMinoMalonaMid)
- Diethyl 2-aminomalonate hydrochloride 99%
- Diethyl aminomalonat
- Diethyl 2-aminopropane-1,3-dioate hydrochloride
- Diethyl aMinoMalonate hydrochloride, 98% 25GR
- 2-Methyl-Malonic acid diethyl ester hydrochloride
- DIETHYL AMINOMALONATE HYDROCHLORIDE FOR
- Diethyl aMinoMalonate hydrochloride 98%
- Diethyl AMinoMalonate Hydrochloride, 95+%
- Propanedioic acid, 2-amino-, 1,3-diethyl ester, hydrochloride (1:1)
- Diethyl aminomalote hydrochloride
- AMINOMALONIC ACID DIETHYL ESTER HCL
- AMINOMALONIC ACID DIETHYL ESTER HYDROCHLORIDE
- DIETHYLAMINO MALONATE HCL
- DIETHYL AMINOMALONATE HYDROCHLORIDE
- Diethyl 2-Aminomalonate HCl
- Propanedioic acid, amino-, diethyl ester, hydrochloride
- aminomalonic acid dlethyl ester hydrochloride
- Diethyl aminomalonate hydrochloride, 98%+
- Amoxapine Impurity 6
- DiethylAminomalonateHydrochloride>
- Diethyl aminmalonic acid hydrochloride
- Diethylaminomalonathydrochlorid
- Favipiravir SW(starting materials)
- Malonic acid, amino-, diethyl ester, hydrochloride
- Diethyl 3-aminomalonate hydrochloride
- Two amino malonic acid ethyl ester hydrochloride
- AminomaL
- onate HydrochL
- aminomalonate hydrochloride
- Aminomalonamid
- DIETHYL 2-AMINOMALONATE HYDROCHLORIDE
- Diethyl 2-aminomalonate
- diethyl 2-aminopropanedioate
- TERT-BUTYL4-(2-(2-HYDROXYETHOXY)ETHYL)PIPERAZINE-5-CARBOXYLATE
- 2-amino-Propanedioic acid 1,3-diethyl ester hydrochloride (1:1)
- 2-Amino-malonic acid 1,3-diethyl ester HCl
- Amoxapine Impurity 2 HCl
- 13433-00-6
- C7H13NO4xHCl
- C7H13NO4HCl
- NH2CH2COOC2H52HCl
- C7H14ClNO4
- C7H13NO4ClH
- AMINE
- Building Blocks
- C6 to C7
- Carbonyl Compounds
- Organic Building Blocks
- Esters
- Building Blocks
- C6 to C7
- Carbonyl Compounds
- Chemical Synthesis
- Esters
