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Lys05

Lys05 Struktur
1391426-24-6
CAS-Nr.
1391426-24-6
Englisch Name:
Lys05
Synonyma:
LSY-05;Lys01 3HCl;lys05(3hcl);Lys05 >=98% (HPLC);Lys05 (hydrochloride);Lys05 trihydrochloride;COMPONENT: 1391426-22-4;Lys01 (trihydrochloride);Lys05 (Lys01 trihydrochloride);Lys05(Component: 1391426-22-4)
CBNumber:
CB03166387
Summenformel:
C23H24Cl3N5
Molgewicht:
476.83
MOL-Datei:
1391426-24-6.mol

Lys05 Eigenschaften

storage temp. 
Store at -20°C
L?slichkeit
DMSO:12.0(Max Conc. mg/mL);21.83(Max Conc. mM)
Water:4.7(Max Conc. mg/mL);8.55(Max Conc. mM)
Aggregatzustand
A crystalline solid
Farbe
Light brown to gray
InChIKey
KXCXCUSYQCJULU-UHFFFAOYSA-N
SMILES
N(C1=CC=NC2C=C(Cl)C=CC1=2)CCN(C)CCNC1=CC=NC2C=C(Cl)C=CC1=2.Cl

Sicherheit

Lys05 Chemische Eigenschaften,Einsatz,Produktion Methoden

Biochem/physiol Actions

Lys05 (Lys01 trihydrochloride) is a dimeric chloroquine (CQ) that deacidifies the lysosome and causes impairment of lysosomal enzymes, exhibiting more than 10-fold higher autophagy inhibitory potency than hydroxychloroquine (HCQ) and CQ (LC3II/LC3I ratio = 15.4 post 4 hr 10 μM treatment in LN229 glioblastoma cells vs. <6.4 with 100 μM CQ or HCQ). Lys05 also shows higher anticancer activity both in vitro (IC50 3.6-6.0 μM vs. 15.6-23.8 μM with HCQ in 1205Lu, c8161, LN229, HT-29 cultures) and in mice in vivo (EC50 in reducing tumor growth rate ~10 mg/kg/day i.p.; HT29 xenografts) with toxicity observed only at high doses (≥80 mg/kg) as a result of significant lysozyme reduction.

Lys05 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Lys05 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 68)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795
ivan@atkchemical.com China 32956 60
BOC Sciences
+1-631-485-4226
inquiry@bocsci.com United States 19553 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
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Career Henan Chemica Co
+86-0371-86658258 +8613203830695
laboratory@coreychem.com China 30238 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD
86-571-88216897,88216896 13588875226
sales@hzclap.com CHINA 6312 58
InvivoChem
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sales@invivochem.cn United States 6391 58
Nanjing Doge Biomedical Technology Co., Ltd
+86-25-58227606 +86-15305155328
sales@dogechemical.com China 4128 58
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd
+8618829768577
gao490372054@gamil.com China 1249 58
Nantong HI-FUTURE Biology Co., Ltd.
+undefined18051384581
sales@chemhifuture.com China 3135 58
TargetMol Chemicals Inc.

support@targetmol.com United States 38631 58

  • Lys01 (trihydrochloride)
  • lys05(3hcl)
  • Lys05 trihydrochloride
  • Lys01 3HCl
  • COMPONENT: 1391426-22-4
  • Lys05(Component: 1391426-22-4)
  • Lys05 (Lys01 trihydrochloride)
  • Lys05 >=98% (HPLC)
  • Lys05 (hydrochloride)
  • N1-(7-Chloroquinolin-4-yl)-N2-(2-((7-chloroquinolin-4-yl)amino)ethyl)-N2-methylethane-1,2-diamine trihydrochloride
  • Inhibitor,Lys-05,Autophagy,inhibit,Lys 05,Lys05
  • LSY-05
  • 1391426-24-6
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