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Allisartan Isoproxil

Allisartan Isoproxil Struktur
947331-05-7
CAS-Nr.
947331-05-7
Englisch Name:
Allisartan Isoproxil
Synonyma:
Allisartan;Losartan Impurity N9;Allisartan Isoproxil;Losartan Impurity 19(Allisartan Isoproxil);1H-Imidazole-5-carboxylic acid, 2-butyl-4-chloro-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-, [[(1-methylethoxy)carbonyl]oxy]methyl ester
CBNumber:
CB03159860
Summenformel:
C27H29ClN6O5
Molgewicht:
553.01
MOL-Datei:
947331-05-7.mol

Allisartan Isoproxil Eigenschaften

Siedepunkt:
745.0±70.0 °C(Predicted)
Dichte
1.35±0.1 g/cm3(Predicted)
pka
4.16±0.10(Predicted)
Aggregatzustand
Solid
Farbe
White to off-white

Sicherheit

Allisartan Isoproxil Chemische Eigenschaften,Einsatz,Produktion Methoden

Clinical Use

Allisartan isoproxil, a member of a new class of selective angiotensin II-1 receptor antagonists, was approved by the Chinese Food and Drug Administration (CFDA) for the treatment of hypertension in July 2012.19 At time of publication, there is no trade name associated with this drug. Allisartan was discovered and developed by the Chinese biomedical company Allist Pharmaceuticals. Allisartan isoproxil is a prodrug which is readily hydrolyzed to active metabolite EXP3174, which is also the active metabolite of losartan (des-triphenylmethyl-9).

Synthese

Although several synthetic routes have been reported within two patents, the most likely scalable process route is described in the scheme. Commercial 2-butyl-4-chloro-5-(hydroxymethyl)-imidazole (7) was alkylated with Ntriphenylmethyl- 5-(4'-bromomethylbiphenyl-2-yl)tetrazole (8) under basic conditions in warm DMF, providing alcohol 9 in 90% yield. This alcohol was then oxidized to the corresponding carboxylic acid 10 with KMnO4 in 88% yield. Etherification of acid 10 with isopropyl chloromethyl carbonate (11) followed by de-tritylation of the tetrazole group under acidic contidions gave allisartan isoproxil (II) in 69% yield.

Synthesis_947331-05-7

Allisartan Isoproxil Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Allisartan Isoproxil Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 23)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 32161 58
Zhejiang J&C Biological Technology Co.,Limited
+1-2135480471 +1-2135480471
sales@sarms4muscle.com China 10473 58
Hebei Miaoyin Technology Co.,Ltd
+86-17367732028 +86-17367732028
kathy@hbyinsheng.com China 3512 58
Cdreamlab (Hubei) Technology Co., LTD 0717-6300888 18062399888
service@cdreamlab.com China 299 58
Allikang Pharmaceutical Co., LTD 0573-87390950 13806705416
wzj@alicornpharma.com China 57 58
Nanjing Sunlida Biological Technology Co., Ltd. 025-57798810
sales@sunlidabio.com China 3239 55
Nanjing Chalf-Pharm Technology Co., Ltd. 025-57018978 18251899859
sales@chalf-pharm.com China 5800 50
Chengdu DingDang Pharmaceutical Co., Ltd. 028-86040038 13980902949;
market@dingdangchem.com China 1845 55
Shenzhen SUNGENING Bio-Medical Co., Ltd. 0755-28967200 13631290199
wxf@sungening.com China 9578 60
Chengdu Novel Biomedical Co., Ltd. 028-85255396 18302801538
cdnovell@163.com China 2314 58

947331-05-7()Verwandte Suche:


  • Allisartan Isoproxil
  • 1H-Imidazole-5-carboxylic acid, 2-butyl-4-chloro-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-, [[(1-methylethoxy)carbonyl]oxy]methyl ester
  • Losartan Impurity 19(Allisartan Isoproxil)
  • Allisartan
  • Losartan Impurity N9
  • 947331-05-7
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