CP 94253 hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
CP 94,253 is an agonist of the serotonin (5-HT) receptor subtype 5-HT
1B (K
i = 2 nM in a radioligand binding assay). It is selective for 5-HT
1B over 5-HT
1A, 5-HT
1D, 5-HT
1C, and 5-HT
2 receptors (K
is = 89, 49, 860, and 1,600 nM, respectively). CP 94,253 (10 and 17 mg/kg) reduces aggressive behavior in a resident-intruder test in mice, as well as decreases alcohol-induced aggression in mice with an ED
50 value of 3.8 mg/kg. It decreases the time mice spend immobile in the forced swim test by 43%, indicating antidepressant-like activity, when administered at a dose of 5 mg/kg. CP 94,253 (2.5 mg/kg) also increases drinking in the Vogel punished drinking task, indicating anxiolytic-like activity, in rats.
Verwenden
CP 94253 Hydrochloride is a potent and selective serotonin 5-HT1B receptor agonist with anticonvulsant activity.
CP 94253 hydrochloride Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
