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N-[(1R,3S)-3-Hydroxy-1-(hydroxymethyl)-3-phenylpropyl]dodecanamide

N-[(1R,3S)-3-Hydroxy-1-(hydroxymethyl)-3-phenylpropyl]dodecanamide Struktur
383418-30-2
CAS-Nr.
383418-30-2
Englisch Name:
N-[(1R,3S)-3-Hydroxy-1-(hydroxymethyl)-3-phenylpropyl]dodecanamide
Synonyma:
HPA-12;N-[(2R,4S)-1,4-Dihydroxy-4-phenylbutan-2-yl]dodecanamide;N-[(1R,3S)-3-Hydroxy-1-(hydroxymethyl)-3-phenylpropyl]dodecanamide;Dodecanamide, N-[(1R,3S)-3-hydroxy-1-(hydroxymethyl)-3-phenylpropyl]-;N-[(1R,3S)-3-Hydroxy-1-(hydroxymethyl)-3-phenylpropyl]dodecanamide
CBNumber:
CB03069617
Summenformel:
C22H37NO3
Molgewicht:
363.53
MOL-Datei:
383418-30-2.mol

N-[(1R,3S)-3-Hydroxy-1-(hydroxymethyl)-3-phenylpropyl]dodecanamide Eigenschaften

storage temp. 
2-8°C
L?slichkeit
Chloroform: soluble; DMSO: soluble
Aggregatzustand
powder to crystal
Farbe
White to Almost white
CAS Datenbank
383418-30-2

Sicherheit

HS Code  2924.29.7790

N-[(1R,3S)-3-Hydroxy-1-(hydroxymethyl)-3-phenylpropyl]dodecanamide Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

HPA-12 is a ceramide analog and inhibitor of ceramide transfer protein (CERT). It inhibits binding of a ceramide probe to the isolated steroidogenic acute regulatory protein-related lipid transfer (START) domain of CERT with an EC50 value of 4 μM in a TR-FRET assay. HPA-12 (2.5 μM) inhibits conversion of the fluorescent ceramide analog C5-DMB-Cer to C5-DMB-sphingomyelin in CHO and HeLa cells. It also inhibits sphingomyelin synthesis in wild-type, but not ATP-dependent ceramide transport-deficient, CHO cells when used at a concentration of 1 μM.

N-[(1R,3S)-3-Hydroxy-1-(hydroxymethyl)-3-phenylpropyl]dodecanamide Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

N-[(1R,3S)-3-Hydroxy-1-(hydroxymethyl)-3-phenylpropyl]dodecanamide Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 21)Lieferanten
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  • N-[(1R,3S)-3-Hydroxy-1-(hydroxymethyl)-3-phenylpropyl]dodecanamide
  • HPA-12
  • N-[(1R,3S)-3-Hydroxy-1-(hydroxymethyl)-3-phenylpropyl]dodecanamide
  • Dodecanamide, N-[(1R,3S)-3-hydroxy-1-(hydroxymethyl)-3-phenylpropyl]-
  • N-[(2R,4S)-1,4-Dihydroxy-4-phenylbutan-2-yl]dodecanamide
  • 383418-30-2
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