5HPP-33
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- CAS-Nr.
- 105624-86-0
- Englisch Name:
- 5HPP-33
- Synonyma:
- 5HPP-33;5-Hydroxy-2-(2,6-diisopropylphenyl)-1H-isoindole-1,3-dione;2-[2,6-bis(1-Methylethyl)phenyl]-5-hydroxy-1H-isoindole-1,3(2H)-dione;1H-Isoindole-1,3(2H)-dione, 2-[2,6-bis(1-methylethyl)phenyl]-5-hydroxy-
- CBNumber:
- CB02751005
- Summenformel:
- C20H21NO3
- Molgewicht:
- 323.39
- MOL-Datei:
- 105624-86-0.mol
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5HPP-33 Eigenschaften
- storage temp.
- 2-8°C
- L?slichkeit
- DMSO: >20mg/mL
- Aggregatzustand
- solid
- Farbe
- white to off-white
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
N |
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| R-S?tze: |
50/53 |
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| S-S?tze: |
60-61 |
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| RIDADR |
UN 3077 9 / PGIII |
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| WGK Germany |
3 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H410 |
Sehr giftig für Wasserorganismen mit langfristiger Wirkung. |
Langfristig (chronisch) gew?ssergef?hrdend |
Kategorie 1 |
Warnung |
![GHS hazard pictograms]() src="/GHS09.jpg" width="20" height="20" /> |
P273, P391, P501 |
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| Sicherheit |
| P273 |
Freisetzung in die Umwelt vermeiden. |
| P501 |
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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5HPP-33 Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
5HPP-33 is a compound that was initially identified for its anti-angiogenic properties. It suppresses microtubule dynamics and depolymerises microtubule network by binding at vinblastine site on tubulin. It is a thalidomide derivative which was reported to be active as anticancer agent through stabilization of the microtubules.
Verwenden
5HPP-33 is a thalidomide derivative with cell-proliferation inhibitory properties.
Biochem/physiol Actions
5HPP-33 is a thalidomide derivative which was reported to be active as anticancer agent through stabilization of the microtubules. 5HPP-33 has shown inhibition of cell proliferation of both estrogen-dependent (MCF-7) and estrogen-independent (MDA-MB-231) breast cancer cells as well as other cell lines. A study in tubulin forming assay reported that 5HPP-33 acts as a microtubule formation inhibitor (IC50=810 nM).
5HPP-33 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
5HPP-33 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 24)Lieferanten
- 2-[2,6-bis(1-Methylethyl)phenyl]-5-hydroxy-1H-isoindole-1,3(2H)-dione
- 5HPP-33
- 5-Hydroxy-2-(2,6-diisopropylphenyl)-1H-isoindole-1,3-dione
- 1H-Isoindole-1,3(2H)-dione, 2-[2,6-bis(1-methylethyl)phenyl]-5-hydroxy-
- 105624-86-0
