Lorlatinib
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- CAS-Nr.
- 1454846-35-5
- Englisch Name:
- Lorlatinib
- Synonyma:
- PF0643922;Loratinib;PF-06463922;PF-6463922;140539;CS-1727;PF6463922;Lorbrena.;EOS-60936;Laratinib
- CBNumber:
- CB02716543
- Summenformel:
- C21H19FN6O2
- Molgewicht:
- 406.41
- MOL-Datei:
- 1454846-35-5.mol
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Lorlatinib Eigenschaften
- Schmelzpunkt:
- 184-187°C
- Siedepunkt:
- 675.0±55.0 °C(Predicted)
- Dichte
- 1.42±0.1 g/cm3(Predicted)
- storage temp.
- Hygroscopic, -20°C Freezer, Under inert atmosphere
- L?slichkeit
- Chloroform (Slightly), Ethyl Acetate (Slightly)
- Aggregatzustand
- Solid
- pka
- 6.05±0.40(Predicted)
- Farbe
- White to Off-White
- Stabilit?t:
- Hygroscopic
- InChI
- InChI=1S/C21H19FN6O2/c1-11-15-7-13(22)4-5-14(15)21(29)27(2)10-16-19(17(8-23)28(3)26-16)12-6-18(30-11)20(24)25-9-12/h4-7,9,11H,10H2,1-3H3,(H2,24,25)/t11-/m1/s1
- InChIKey
- IIXWYSCJSQVBQM-LLVKDONJSA-N
- SMILES
- [C@@H]1(C)C2=CC(F)=CC=C2C(=O)N(C)CC2=NN(C)C(C#N)=C2C2C=C(C(N)=NC=2)O1
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H341 |
Kann vermutlich genetische Defekte verursachen. |
Keimzellmutagenit?t |
Kategorie 2 |
Warnung |
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P201,P202, P281, P308+P313, P405,P501 |
| H373 |
Kann die Organe sch?digen bei l?ngerer oder wiederholter Exposition. |
Spezifische Zielorgan-Toxizit?t (wiederholte Exposition) |
Kategorie 2 |
Warnung |
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P260, P314, P501 |
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| Sicherheit |
| P201 |
Vor Gebrauch besondere Anweisungen einholen. |
| P202 |
Vor Gebrauch alle Sicherheitshinweise lesen und verstehen. |
| P260 |
Dampf/Aerosol/Nebel nicht einatmen. |
| P281 |
Vorgeschriebene pers?nliche Schutzausrüstung verwenden. |
| P308+P313 |
BEI Exposition oder falls betroffen: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen. |
| P314 |
Bei Unwohlsein ?rztlichen Rat einholen / ?rztliche Hilfe hinzuziehen. |
| P405 |
Unter Verschluss aufbewahren. |
| P501 |
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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Lorlatinib Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase that promotes cell proliferation and blocks apoptosis. PF-06463922 is an ATP-competitive, selective inhibitor of ALK (Ki = < 0.07 nM) and c-Ros oncogene 1 (ROS1, Ki = 0.7 nM). It has strong activity against all known ALK and ROS1 mutants identified in patients, including the EML4-L1196M mutant of ALK (Ki = < 0.02 nM). PF-06463922 is orally available, displaying inhibition of ALK phosphorylation and antitumor efficacy in a xenograft model expressing EML4-L1196M ALK. It demonstrates efficient blood-brain barrier penetration, produces brain tumor regression in mice harboring EML4-ALK tumors, and increases overall survival.[Cayman Chemical]
Trademarks
Lorbrena?
Enzyminhibitor
This potent, dual ALK/ROS1 inhibitor (FW = 406.41 g/mol; CAS 1454846- 35-5), also named (10R)-7-amino-12-fluoro-10,15,16,17-tetrahydro- 2,10,16-trimethyl-15-oxo-2H-4,8-methenopyrazolo[4,3- h][2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile, targets the protooncogene tyrosine-protein kinase ROS1 (Ki < 0.02 nM) as well as wild-type anaplastic lymphoma kinase ALKWT (Ki < 0.07 nM) and its Leu-to-Met mutant ALKL1196M (Ki of = 0.7 nM). PF-06463922 significantly inhibits cell proliferation and induces cell apoptosis in the HCC78 human NSCLC cells harboring SLC34A2-ROS1 fusions and the BaF3-CD74-ROS1 cells expressing human CD74-ROS1
Lorlatinib Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Lorlatinib Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 322)Lieferanten
- (10R)-7-Amino-12-fluoro-10,15,16,17-tetrahydro-2,10,16-trimethyl-15-oxo-2H-4,8-methenopyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile
- Lorlatinib,PF-06463922
- PF-06463922, Lorlatinib
- (R)-26-amino-55-fluoro-11,4,7-trimethyl-6-oxo-11H-3-oxa-7-aza-2(3,5)-pyridina-1(4,3)-pyrazola-5(1,2)-benzenacyclooctaphane-15-carbonitrile
- Lorlatinib(PF0643922)
- High Purity API Lorlatinib
- Anaplastic lymphoma kinase (ALK)
- Lorlatinib Powder
- 2H-4,8-Methenopyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile, 7-amino-12-fluoro-10,15,16,17-tetrahydro-2,10,16-trimethyl-15-oxo-, (10R)-
- 140539
- LORLATINIB API
- Lorlatinib Lorlatinib
- Loratinib (PF-06463922)
- CS-1727
- LAOLA TINI
- PF06463922;PF-06463922;PF 06463922
- Lauratinib
- PF6463922
- PF06463922; PF 06463922; PF-06463922; PF-6463922; PF6463922; PF 6463922; LORLATINIB; LORBRENA.
- PF 6463922
- Lorbrena.
- INC280INC280
- lee011/inc280
- EOS-60936
- Lorlatinib (PF-06463922) USP/EP/BP
- (10R)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]-benzoxadiazacyclotetradecine-3-carbonitrile
- PF 06463922
DISCONTINUED
- Lorlatinib 13CD3
- PF0643922
- PF-06463922
- PF-6463922
- Loratinib
- Laura for,
- Top quality 1454846-35-5 Lorlatinib (PF-06463922)
- 13C,2H3]-Lorlatinib
- ALK tyrosine kinase receptor,Anaplastic lymphoma kinase,tyrosine,Apoptosis,PF 06463922,inhibit,Neuroblastoma,Carcinoma,Anaplastic lymphoma kinase (ALK),NSCLC,Inhibitor,Lorlatinib,mutation,kinase,Cluster of differentiation 246,brain-penetrant,ROS Kinase,CD246,third-generation,PF06463922
- Laratinib
- Lorlatinib?(PF-6463922)
- Lorlatinib
- (10R)-7-Amino-12-fluoro-10,15,16,17-tetrahydro-2,10,16-trimethyl-15-oxo-2H-4,8-methenopyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile (ACI)
- Bromopropylate Impurity 15
- Lorlatinib, 10 mM in DMSO
- 1454846-35-5
- 1545846-35-5
- C21H19FN6O2
- API
- Inhibitors
- 1
