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TPPU

TPPU Struktur
1222780-33-7
CAS-Nr.
1222780-33-7
Englisch Name:
TPPU
Synonyma:
TPPU;CS-2462;TPPU(CS-2462);TPPU Exclusive;TPPU >=98% (HPLC);inhibit,Inhibitor,TPPU,Epoxide Hydrolase;1-Trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl) urea;1-(1-Propionylpiperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)urea;N-[1-(1-Oxopropyl)-4-piperidinyl]-N′-[4-(trifluoromethoxy)phenyl]-urea;Urea, N-[1-(1-oxopropyl)-4-piperidinyl]-N'-[4-(trifluoromethoxy)phenyl]-
CBNumber:
CB02592718
Summenformel:
C16H20F3N3O3
Molgewicht:
359.34
MOL-Datei:
1222780-33-7.mol

TPPU Eigenschaften

Schmelzpunkt:
195-196 °C
Siedepunkt:
448.9±45.0 °C(Predicted)
Dichte
1.31±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
L?slichkeit
DMSO: soluble10mg/mL, clear (warmed)
Aggregatzustand
powder
pka
13.11±0.20(Predicted)
Farbe
white to beige
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher T
R-S?tze: 25
S-S?tze: 45
RIDADR  UN 2811 6.1 / PGIII
WGK Germany  3
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H301 Giftig bei Verschlucken. Akute Toxizit?t oral Kategorie 3 Achtung GHS hazard pictogramssrc="/GHS06.jpg" width="20" height="20" /> P264, P270, P301+P310, P321, P330,P405, P501
Sicherheit
P301+P310 BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.

TPPU Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Soluble epoxide hydrolase (sEH) converts epoxides to their corresponding diols. Inhibitors of sEH have anti-inflammatory, anti-hypertensive, neuroprotective, and cardioprotective effects. TPPU is a potent inhibitor of both human and mouse sEH (IC50 = 3.7 and 2.8 nM, respectively). The pharmacokinetics of this compound are dramatically superior to those of the 1-adamantylurea based inhibitors, like AUDA.[Cayman Chemical]

Biochem/physiol Actions

TPPU is a potent sEH inhibitor (IC50 = 3.7 nM) that has been shown to have very favorable PK attributes in cynomolgus monkeys. sEH converts epoxyeicosatrienoic acids (EETs) to dihydroxyiecosatrienoic acids (DHETs), and sEH inhibitors display anti-inflammatory and anti-atherosclerotic effects.

TPPU Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

TPPU Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 64)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
ivan@atkchemical.com China 32956 60
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 32161 58
Career Henan Chemica Co 		+86-0371-86658258 +8613203830695
 laboratory@coreychem.com China 30238 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226
 sales@hzclap.com CHINA 6312 58
InvivoChem 		+1-708-310-1919 +1-13798911105
 sales@invivochem.cn United States 6391 58
TargetMol Chemicals Inc.
support@targetmol.com United States 38631 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		13417589054
 trendseenbio@gmail.com China 11681 58
Wuhan Topule Biopharmaceutical Co., Ltd 		+8618327326525
 masar@topule.com China 8467 58
Aladdin Scientific 		+1-+1(833)-552-7181
sales@aladdinsci.com United States 57505 58
Shanghai Boyle Chemical Co., Ltd.
sales@boylechem.com China 2922 55
  • 1-Trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl) urea
  • N-[1-(1-Oxopropyl)-4-piperidinyl]-N′-[4-(trifluoromethoxy)phenyl]-urea
  • TPPU Exclusive
  • TPPU
  • CS-2462
  • Urea, N-[1-(1-oxopropyl)-4-piperidinyl]-N'-[4-(trifluoromethoxy)phenyl]-
  • TPPU >=98% (HPLC)
  • TPPU(CS-2462)
  • 1-(1-Propionylpiperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)urea
  • inhibit,Inhibitor,TPPU,Epoxide Hydrolase
  • 1222780-33-7
  • C16H20F3N3O3
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