Ro 67-7476 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Ro 67-7476 is a positive allosteric modulator of metabotropic glutamate receptor 1 (mGluR1) that enhances glutamate-induced calcium release in HEK293 cells expressing rat mGluR1a (EC₅₀ = 1.74 μM). It is selective for rat mGluR1 over rat mGluR2, mGluR4, and mGluR8 at a concentration of 10 μM. Ro 67-7476 increases the amplitude of mGluR1 excitatory postsynaptic potentials (EPSCs) evoked by 2,3-dihydroxy-6-nitro-7-sulfamoylbenzoquionxaline, picrotoxin, or AP5 in the Purkinje cells of rat cerebellar slices. It activates ERK1/2 phosphorylation in the absence of exogenously added glutamate (EC₅₀ = 163.3 nM).

Verwenden

Ro 67-7476 is a positive allosteric metabotropic mGlu1 receptor modulator.

Ro 67-7476 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Ro 67-7476 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32161	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
TargetMol Chemicals Inc.		support@targetmol.com	United States	38631	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	52924	58
Nanjing Norris-Pharm Technology Co., Ltd	13901585132	799750417@qq.com	China	8878	55
MedChemexpress LLC	021-58955995	sales@medchemexpress.cn	United States	4861	58
EnliPharma Technology Co., Ltd	0551-66399836 18955197623	sales@enlipharma.com	China	1874	55
EMMX Biotechnology LLC	888-539-0666	info@emmx.com	United States	8447	60
Shanghai Changyan Chem & Tech Co., Ltd.	021-20242659 18930833303	Sales@changyanchem.cn	China	5010	55
ShangHai Biochempartner Co.,Ltd	177-54423994 17754423994	2853530910@QQ.com	China	8011	62

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• 298690-60-5