PLX4032
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- CAS-Nr.
- 918504-65-1
- Englisch Name:
- PLX4032
- Synonyma:
- R7204;104532;CS-1916;Vemurafenib, >=99%;PLX4032 (VeMurafenib);Zelboraf (vemurafenib);(1029872-54-5) vemurafenib;Vemurafenib (10mM in DMSO);Vemurafenib (RG7204,PLX4032);VeMurafenib (PLX4032, RG7204)
- CBNumber:
- CB02550000
- Summenformel:
- C23H18ClF2N3O3S
- Molgewicht:
- 489.92
- MOL-Datei:
- 918504-65-1.mol
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PLX4032 Eigenschaften
- Dichte
- 1.46
- storage temp.
- -20°C
- L?slichkeit
- Soluble in DMSO (up to 100 mg/ml)
- Aggregatzustand
- White powder.
- pka
- 6.26±0.10(Predicted)
- Farbe
- White or off-white
- Stabilit?t:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
- CAS Datenbank
- 918504-65-1
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H410 |
Sehr giftig für Wasserorganismen mit langfristiger Wirkung. |
Langfristig (chronisch) gew?ssergef?hrdend |
Kategorie 1 |
Warnung |
![GHS hazard pictograms]() src="/GHS09.jpg" width="20" height="20" /> |
P273, P391, P501 |
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| Sicherheit |
| P273 |
Freisetzung in die Umwelt vermeiden. |
| P391 |
Verschüttete Mengen aufnehmen. |
| P501 |
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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PLX4032 Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
In August 2011, the United States FDA approved vemurafenib (PLX-
4032, RO-5185426) for the treatment of patients with metastatic melanoma
with the BRAFV600E mutation. Vemurafenib has been developed as a
targeted therapy for patients with the BRAF gene mutation since oncogenic
B-raf signaling is implicated in approximately 50% of melanomas. Vemurafenib was identified based on an initial high-throughput screen followed by the extensive use of structure-based drug design. Vemurafenib is a potent inhibitor of B-RafV600E kinase (IC
50=13 nM) compared to its potency against wildtype B-raf (IC
50=160 nM) and is fairly selective versus a panel of 200
kinases. It does inhibit other kinases (RAF1, SRMS, ACK1,
MAP4K5, and FGR) and mutant B-raf kinases (BRAFV600K,
BRAFV600D, and BRAFV600R) with enzyme IC
50's of <100 nM.
Chemische Eigenschaften
Off-White Solid
Verwenden
Vemurafenib selective BRAFV600E kinase inhibitor; an antitumor agent. Vemurafenib functions by inhibiting the proliferation and mitogen-activated protein/extracellular signal-regulated kinase (ERK) kinase and ERK phosphorylation in a panel of tumor cell lines, including melanoma cell lines expressing BRAFV600E or other mutant BRAF proteins altered at codon 600.
Definition
ChEBI: A pyrrolopyridine that is 1H-pyrrolo[2,3-b]pyridine which is substituted at position 5 by a p-chlorophenyl group and at positions 3 by a 3-amino-2,6-difluorobenzoyl group, the amino group of which has undergone
ormal condensation with propane-1-sulfonic acid to give the corresponding sulfonamide. An inhibitor of BRAF and other kinases.
PLX4032 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
PLX4032 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 254)Lieferanten
- N-(3-(5-(4-Chlorophenyl)-1H-pyrrolo[2,3-B]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonaMide
- PLX4032 (VeMurafenib)
- PLX4032, RG7204, ZELBORAF, RO5185426
- R7204
- N-(3-(5-(4-Chlorophenyl)-1H-pyrrolo[2,3-B]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonaM
- PLX4032, R7204, RG7204, RO5185426
- VeMurafenib (PLX4032, RG7204)
- N-[3-[[5-(4-Chlorophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]-2,4-difluorophenyl]-1-propanesulfonamide Vemurafenib PLX 4032
- Zelboraf (vemurafenib)
- Vemurafenib, >=99%
- Vemurafenib (RG7204,PLX4032)
- RG7204;PLX-4032;PLX 4032;RG-7204
- CS-1916
- PLX 4032 - RG 7204 | Vemurafenib | RO 5185426
- 104532
- (1029872-54-5) vemurafenib
- N-(3-(5-(4-Chlorophenyl)-1H-pyrrolo[2,3-B]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonaMide USP/EP/BP
- Vemurafenib (10mM in DMSO)
- VemurafenibQ: What is
Vemurafenib Q: What is the CAS Number of
Vemurafenib Q: What is the storage condition of
Vemurafenib Q: What are the applications of
Vemurafenib
- Raf kinases,Vemurafenib,inhibit,PLX 4032,Inhibitor,RO-5185426,RG 7204,Raf,Autophagy,RG-7204,RO 5185426,PLX-4032
- 918504-65-1
- API
- Heterocycles
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Protein Kinase Inhibitors and Activators
- Sulfur & Selenium Compounds
- Inhibitor
- RG7204
- Antineoplastic
- MAPK
- Inhibitors
- Aromatics
