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Methyl 5-fluoro-2-methyl-3-nitrobenzoate

Methyl 5-fluoro-2-methyl-3-nitrobenzoate Struktur
697739-03-0
CAS-Nr.
697739-03-0
Englisch Name:
Methyl 5-fluoro-2-methyl-3-nitrobenzoate
Synonyma:
104157;5-fluoro-2-methyl-3-nitrobenzoic acid;Methyl 5-fluoro-2-Methy-3-nitrobenzoate;5-fluoro-2-Methyl-3-nitro-, Methyl ester;methyl 5-fluoro-2-methyl-3-nitrobenzoate;5-FLUORO-2-METHYL-3-NITRO-BENZOIC ACID METHYL ESTER;Benzoic acid, 5-fluoro-2-Methyl-3-nitro-, Methyl ester
CBNumber:
CB02466127
Summenformel:
C9H8FNO4
Molgewicht:
213.16
MOL-Datei:
697739-03-0.mol

Methyl 5-fluoro-2-methyl-3-nitrobenzoate Eigenschaften

Siedepunkt:
297.7±40.0 °C(Predicted)
Dichte
1.335±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
L?slichkeit
Slightly soluble in water. Soluble in dimethyl sulfoxide and acetone.
Farbe
White

Sicherheit

HS Code  2916399090

Methyl 5-fluoro-2-methyl-3-nitrobenzoate Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Methyl 5-fluoro-2-methyl-3-nitrobenzoate is used in organic synthesis and it is used in the synthesis of 6-Fluoro-4-nitroisobenzofuran-1 (3H)-one.

synthetische

Methyl 5-fluoro-2-methyl-3-nitrobenzoate synthesis: To a solution of conc. H2SO4 (700mL) was added portionwise 5-fluoro-2-methylbenzoic acid (80g, 520 mmol) at -5-0°C. Then a mixture of conc. HNO3(60.4 g. 624 mmol) in conc. H2SO4 (60 mL) was added drop-wise at -5-0°C. in a period of about 1.5 hrs. After the addition, the mixture was stirred at this temperature for 2 hrs. TLC (petroleum ether/ EtOAc=1:1) showed the reaction was complete. The mixture was poured into crash ice with vigorous stirring and the precipitate was collected by filtration. The precipitate was dissolved in EtOAc, washed with brine, dried over anhydrous Na2SO4 concentrated to give crude 5-fluoro-2-methyl-3-nitrobenzoic acid (54 g). A solution of this crude 5-fluoro-2-methyl-3-nitrobenzoic acid (54 g) in dry methanol (500 mL) was cooled to 0°C., SOCl2 (64.52g, 542.3 mmol) was added drop-wise. After the addition, the mixture was heated to reflux for 16hrs. TLC (petroleum ether/EtOAc=1:1) showed the reaction was complete. Solvent was removed under reduced pressure to give crude product. The crude product was purified by silica gel chromatography (petroleum ether to petro leum ether/EtOAc=50: 1) to give methyl 5-fluoro-2-methyl-3-nitrobenzoate (28 g, yield 25% for two steps) as a white solid.

Methyl 5-fluoro-2-methyl-3-nitrobenzoate Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Methyl 5-fluoro-2-methyl-3-nitrobenzoate Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 168)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Zhejiang Karry Pharmachem Co., Ltd.
+8613567161161
info@karrypharma.com China 34 58
Capot Chemical Co.,Ltd.
+86-(0)57185586718 +86-13336195806
sales@capot.com China 29791 60
Beijing Cooperate Pharmaceutical Co.,Ltd
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Shanghai Yingrui Biopharma Co., Ltd.
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Fluoropharm Co., Ltd.
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ATK CHEMICAL COMPANY LIMITED
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ivan@atkchemical.com China 32956 60
Anqing Chico Pharmaceutical Co., Ltd.
15380796838
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career henan chemical co
+86-0371-86658258 +8613203830695
sales@coreychem.com China 29880 58
Zhejiang ZETian Fine Chemicals Co. LTD
+8618957127338
stella@zetchem.com China 2136 58
Changzhou Ansciep Chemical Co., Ltd.
+86 519 86305871
sales@ansciepchem.com CHINA 4241 58

697739-03-0()Verwandte Suche:


  • 5-FLUORO-2-METHYL-3-NITRO-BENZOIC ACID METHYL ESTER
  • 5-fluoro-2-methyl-3-nitrobenzoic acid
  • Benzoic acid, 5-fluoro-2-Methyl-3-nitro-, Methyl ester
  • 5-fluoro-2-Methyl-3-nitro-, Methyl ester
  • Methyl 5-fluoro-2-Methy-3-nitrobenzoate
  • 104157
  • methyl 5-fluoro-2-methyl-3-nitrobenzoate
  • 697739-03-0
  • 69773-03-3
  • 697739-03-0
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