4H-PYRIDO[1,2-A]PYRIMIDIN-4-ONE, 7-METHYL-2-(4-MORPHOLINYL)-9-[1-(PHENYLAMINO)ETHYL]-
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- CAS-Nr.
- 663619-89-4
- Englisch Name:
- 4H-PYRIDO[1,2-A]PYRIMIDIN-4-ONE, 7-METHYL-2-(4-MORPHOLINYL)-9-[1-(PHENYLAMINO)ETHYL]-
- Synonyma:
- CS-429;TGX 221;TGX-221; TGX 221;TGX-221, 10 mM in DMSO;TGX-221, PI3K inhibitor;TGX221; TGX221; TGX 221.;PI 3-Kβ Inhibitor VI, TGX-221;PI 3-Kβ Inhibitor VI, TGX-221;TGX-221 PI3K inhibitor ab120924;TGX-221, PI3K Inhibitor (±
- CBNumber:
- CB02456412
- Summenformel:
- C21H24N4O2
- Molgewicht:
- 364.44
- MOL-Datei:
- 663619-89-4.mol
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4H-PYRIDO[1,2-A]PYRIMIDIN-4-ONE, 7-METHYL-2-(4-MORPHOLINYL)-9-[1-(PHENYLAMINO)ETHYL]- Eigenschaften
- Schmelzpunkt:
- 198-201oC
- Siedepunkt:
- 557.3±60.0 °C(Predicted)
- Dichte
- 1.25±0.1 g/cm3(Predicted)
- storage temp.
- Hygroscopic, Refrigerator, under inert atmosphere
- L?slichkeit
- DMSO (Slightly), Methanol (Very Slightly)
- pka
- 3.90±0.50(Predicted)
- Aggregatzustand
- Pale yellow solid.
- Farbe
- Off-White to Pale Yellow
Sicherheit
4H-PYRIDO[1,2-A]PYRIMIDIN-4-ONE, 7-METHYL-2-(4-MORPHOLINYL)-9-[1-(PHENYLAMINO)ETHYL]- Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
TGX-221 is a potent, selective, and cell permeable inhibitor of Phosphatidylinositol 3-kinase (PI3K) p110β.
Allgemeine Beschreibung
A cell-permeable morpholino-pyrimidinone compound that acts as a reversible, ATP-competitive, selective, and highly potent inhibitor of PI 3-Kβ (IC
50 = 0.005, 0.1, 5, and ≥3.5 μM for -β, -δ, -α and -γ isoforms, respectively) with little activity against a panel of 15 commonly studied protein kinases even at concentrations as high as 10.0 μM. An excellent tool for studying p110β-dependent responses both in cells
in vitro and in animals
in vivo.
Biochem/physiol Actions
Cell permeable: yes
4H-PYRIDO[1,2-A]PYRIMIDIN-4-ONE, 7-METHYL-2-(4-MORPHOLINYL)-9-[1-(PHENYLAMINO)ETHYL]- Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
4H-PYRIDO[1,2-A]PYRIMIDIN-4-ONE, 7-METHYL-2-(4-MORPHOLINYL)-9-[1-(PHENYLAMINO)ETHYL]- Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 157)Lieferanten
- 4H-PYRIDO[1,2-A]PYRIMIDIN-4-ONE, 7-METHYL-2-(4-MORPHOLINYL)-9-[1-(PHENYLAMINO)ETHYL]-
- TGX 221
- (+/-)-7-Methyl-2-(morpholin-4-yl)-9-(1-phenylaminoethyl)pyrido[1,2-a]pyrimidin-4-one
- 7-methyl-2-(4-morpholinyl)-9-[1-(phenylamino)ethyl]-4H-pyrido[1,2-a]pyrimidin-4-one
- (+/-)-7-Methyl-2-(morpholin-4-yl)-9-(1-phenylaminoethyl)pyrido[1,2-a]pyrimidin-4-one TGX 221
- TGX 221
(+/-)-7-Methyl-2-(morpholin-4-yl)-9-(1-phenylaminoethyl)pyrido[1,2-a]pyrimidin-4-one
- PI 3-Kβ Inhibitor VI, TGX-221
- CS-429
- TGX-221; TGX 221
- TGX-221, PI3K Inhibitor (±
- TGX221; TGX221; TGX 221.
- 9-(1-anilinoethyl)-7-methyl-2-morpholin-4-ylpyrido[1,2-a]pyrimidin-4-one
- 4H-PYRIDO[1,2-A]PYRIMIDIN-4-ONE, 7-METHYL-2-(4-MORPHOLINYL)-9-[1-(PHENYLAMINO)ETHYL]- ISO 9001：2015 REACH
- TGX-221 PI3K inhibitor ab120924
- TGX-221, PI3K inhibitor
- TGX-221, 10 mM in DMSO
- PI 3-Kβ Inhibitor VI, TGX-221
- 663619-89-4
- Inhibitors
- Akt
- mTOR
- PI3K
