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NAGLY

NAGLY Struktur
179113-91-8
CAS-Nr.
179113-91-8
Englisch Name:
NAGLY
Synonyma:
NAGLY;NAGly, CID 5283389;Arachidonyl Glycine;ARACHIDONOYL GLYCINE;N-ARACHIDONYL GLYCINE;N-ARACHIDONOYL GLYCINE;N Arachidonylglycine,NArachidonylglycine;N-Arachidonoyl glycine (solution in ethanol);N-(1-OXO-5Z,8Z,11Z,14Z-EICOSATETRAENYL)GLYCINE;2-((5Z,8Z,11Z,14Z)-Icosa-5,8,11,14-tetraenamido)acetic acid
CBNumber:
CB0232490
Summenformel:
C22H35NO3
Molgewicht:
361.52
MOL-Datei:
179113-91-8.mol

NAGLY Eigenschaften

Siedepunkt:
560.9±50.0 °C(Predicted)
Dichte
0.985±0.06 g/cm3(Predicted)
storage temp. 
−20°C
L?slichkeit
DMSO: >5 mg/mL, soluble
Aggregatzustand
waxy solid
pka
3.58±0.10(Predicted)
Farbe
off-white
Sensitive 
Air Sensitive
Stabilit?t:
Stable for 2 years from date of purchase as supplied. Product is subject to oxidation. Solutions in degassed DMSO may be stored at -20°C for up to 1 month.
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
S-S?tze: 22-24/25
WGK Germany  3
Bildanzeige (GHS) GHS hazard pictogramsGHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H336 Kann Schl?frigkeit und Benommenheit verursachen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Schl?frigkeit und Benommenheit) Warnung P261, P271, P304+P340, P312,P403+P233, P405, P501
H351 Kann vermutlich Krebs verursachen. Karzinogenit?t Kategorie 2 Warnung P201, P202, P281, P308+P313, P405,P501
Sicherheit
P201 Vor Gebrauch besondere Anweisungen einholen.
P302+P352 BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.
P308+P313 BEI Exposition oder falls betroffen: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen.

NAGLY Chemische Eigenschaften,Einsatz,Produktion Methoden

S-S?tze Betriebsanweisung:

S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.

Beschreibung

Arachidonoyl glycine (N-arachidonyl glycine; NAGly) has been isolated from cell cultures treated with arachidonoyl ethanolamide (AEA; anandamide), from extracts of mammalian brain, and has also been synthesized as an analog of AEA for structure/activity testing. NAGly may be produced endogenously via oxidation of AEA, or by transacylation of arachidonoyl CoA. NAGly is reported to have analgesic activities in whole animal experiments. Since it seems to be a very poor ligand for the CB1 receptor, these effects are probably mediated via other signaling pathways.

Verwenden

Arachidonoyl glycine (N-arachidonyl glycine; NAGly) has been isolated from cell cultures treated with arachidonoyl ethanolamide (AEA; anandamide), from extracts of mammalian brain, and has also been synthesized as an analog of AEA for structure/activity testing. NAGly may be produced endogenously via oxidation of AEA, or by transacylation of arachidonoyl CoA. NAGly is reported to have analgesic activities in whole animal experiments. Since it seems to be a very poor ligand for the CB1 receptor, these effects are probably mediated via other signaling pathways.[Cayman Chemical]

Biologische Aktivit?t

Endogenous anandamide-like compound. Lacks affinity for CB 1 receptors (K i > 10 μ M), VR1 receptors (EC 50 > 10 μ M) and anandamide transporters (IC 50 > 50 μ M) but causes hot-plate analgesia in mice when given orally, and suppresses tonic inflammatory pain. Also endogenous GlyT2 inhibitor.

NAGLY Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

NAGLY Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 43)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 32161 58
Alfa Chemistry
Info@alfa-chemistry.com United States 24072 58
Aladdin Scientific 		+1-+1(833)-552-7181
sales@aladdinsci.com United States 57505 58
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037
 3bsc@sina.com China 15839 69
Alfa Chemistry 1-516-6625404
support@alfa-chemistry.com United States 9171 60
EMMX Biotechnology LLC 888-539-0666
info@emmx.com United States 8447 60
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627
 info@efebio.com China 9806 58
Shenzhen Regent Biochemical Technology Co., Ltd. 0755-0755-85201366 18938635012
 sales@regentsciences.com China 9520 58
Jinan Yaoyan Pharmaceutical Co., Ltd.
jnyaoyan@163.com China 3069 58
Nanjing Meihao Pharmaceutical Technology Co., Ltd. meitaochem@126.com
meitaochem@126.com China 19103 58

179113-91-8()Verwandte Suche:

  • N-ARACHIDONOYL GLYCINE
  • N-ARACHIDONYL GLYCINE
  • NAGLY
  • N-(1-OXO-5Z,8Z,11Z,14Z-EICOSATETRAENYL)GLYCINE
  • ARACHIDONOYL GLYCINE
  • N-Arachidonoyl glycine (solution in ethanol)
  • Glycine, N-[(5Z,8Z,11Z,14Z)-1-oxo-5,8,11,14-eicosatetraen-1-yl]-
  • Arachidonyl Glycine
  • NAGly, CID 5283389
  • N Arachidonylglycine,NArachidonylglycine
  • 2-((5Z,8Z,11Z,14Z)-Icosa-5,8,11,14-tetraenamido)acetic acid
  • 179113-91-8
  • Cannabinoid receptor
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