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8-pCPT-2μ-O-Me-cAMP

8-pCPT-2μ-O-Me-cAMP Struktur
634207-53-7
CAS-Nr.
634207-53-7
Englisch Name:
8-pCPT-2μ-O-Me-cAMP
Synonyma:
-O-Me-cAMP;8-pCPT-2’8-pCPT-2μ-O-Me-cAMP;8-pCPT-2'-O-Me-Cyclic AMP (sodium salt);8-(4-Chlorophenylthio)-2′-O-methyladenosine 3′,5′-cyclic monophosphate monosodium hydrate;8-(4-Chlorophenylthio)-2μ-O-methyladenosine 3μ,5μ-cyclic monophosphate hydrate monosodium
CBNumber:
CB02101804
Summenformel:
C17H16ClN5NaO6PS
Molgewicht:
507.82
MOL-Datei:
634207-53-7.mol

8-pCPT-2μ-O-Me-cAMP Eigenschaften

Schmelzpunkt:
235.5-237.5 °C(lit.)
storage temp. 
−20°C
L?slichkeit
H2O: >10mg/mL
Aggregatzustand
solid
Farbe
white
Wasserl?slichkeit
Soluble to 100 mM in water

Sicherheit

S-S?tze: 22-24/25
WGK Germany  3

8-pCPT-2μ-O-Me-cAMP Chemische Eigenschaften,Einsatz,Produktion Methoden

S-S?tze Betriebsanweisung:

S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.

Verwenden

Exchange proteins activated by cAMP (Epacs) are guanine nucleotide exchange factors (GEFs) for the small GTPases Rap1 and Rap2. 8-pCPT-2'-O-Me-cAMP is a super-activator of Epacs in that it dissociates GDP from Rap1 more strongly than the natural Epac agonist, cAMP. 8-pCPT-2'-O-Me-cAMP is strongly selective for Epac over the cAMP-activated kinase PKA. It does not discriminate between Epac1 and Epac2 and is used extensively to elucidate the roles of these Rap GEFs in cell function.[Cayman Chemical]

Biochem/physiol Actions

Analog of natural cAMP, potent and specific membrane-permeant activator of exchange factors directly activated by cAMP (Epac or cAMP-GEF), a new receptor for cyclic AMP

8-pCPT-2μ-O-Me-cAMP Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

8-pCPT-2μ-O-Me-cAMP Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

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  • 8-pCPT-2'-O-Me-Cyclic AMP (sodium salt)
  • 8-(4-Chlorophenylthio)-2μ-O-methyladenosine 3μ,5μ-cyclic monophosphate hydrate monosodium
  • 8-pCPT-2μ-O-Me-cAMP
  • 8-(4-Chlorophenylthio)-2′-O-methyladenosine 3′,5′-cyclic monophosphate monosodium hydrate
  • 8-pCPT-2&rsquo
  • -O-Me-cAMP
  • 634207-53-7
  • C17H16N5O6ClPSNa
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