Candesartan Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R20/21/22:Gesundheitssch?dlich beim Einatmen,Verschlucken und Berührung mit der Haut.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-S?tze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

Chemische Eigenschaften

Crystalline Solid

Verwenden

Candesartan is a selective AT1 (angiotensin II receptor 1) antagonist. Antagonism of angiotensin receptors inhibits vasoconstriction and the production of aldosterone, leading to a decrease in water and sodium concentration in blood plasma. Exhibits antihypertensive effects in animal models. Used in treatment of congestive heart failure, as antihypertensive. Candesartan does not affect cell viability or proliferation but increases the expression of VEGF and interleukin-8 in the cultured medium of KU-19-19 cells. Candesartan (0.1 nM) could reduce the maximal contractile response to angiostensin II by approximately 50%.

Definition

ChEBI: A benzimidazolecarboxylic acid that is 1H-benzimidazole-7-carboxylic acid substituted by an ethoxy group at position 2 and a ({2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl}methyl) group at position 1. It is a angiotensin eceptor antagonist used for the treatment of hypertension.

Allgemeine Beschreibung

Candesartan, (+)-1-[[(cyclohexyloxy)carbonyl]-oxy]ethyl 2- ethoxy-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylate(Atacand), like losartan, possesses the acidic tetrazole system,which most likely plays a role in binding to the angiotensin IIreceptor similarly to the acidic groups of angiotensin II. Also,the imidazole system has been replaced with a benzimidazolepossessing an ester at position. This ester must be hydrolyzedto the free acid. Fortunately, this conversion takesplace fairly easily because of the carbonate in the ester sidechain. This facilitates hydrolysis of the ester so much thatconversion to the free acid takes place during absorption fromthe gastrointestinal tract.

Candesartan Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Candesartan Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Hebei Yanxi Chemical Co., Ltd.	+8617531153977	allison@yan-xi.com	China	5854	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20230	58
Hebei Zhuanglai Chemical Trading Co.,Ltd	+8613343047651	admin@zlchemi.com	China	3692	58
Hebei Shengyang Water Conservancy Engineering Co., Ltd.	+8615373025980	clara@hbshengyang.com	China	822	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21628	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29856	58
Biochempartner	0086-13720134139	candy@biochempartner.com	CHINA	965	58
Standardpharm Co. Ltd.	86-714-3992388	overseasales1@yongstandards.com	United States	14332	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49732	58

139481-59-7()Verwandte Suche:

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• 1-((2'-(1H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)Methyl)-2-ethoxy-1H-benzo[d]iMidazole-7-carboxylic acid
• 2-ethoxy-3-[[4-[2-(1h-tetrazol-5-yl)phenyl]phenyl]methyl]-3h-benzoimidazole-4-carboxylic acid
• 3-[[2'-(1H-Tetrazol-5-yl)biphenyl-4-yl]Methyl]-2-ethoxy-3H-benziMidazole-4- carboxylic Acid
• Candesartan M1
• 2-ETHOXY1-2(1H-TETRAZOL-5YL)1,1-BIPHENYL)-4-YL)-4-YL)METHYL)1H-BENZIMIDAZOLE-7-CARBOXYLIC ACID
• Candesartan Cilexetil EP IMpurity G
• 1-((2'-(1H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylic
• 1H-Benzimidazole-7-carboxylic acid, 2-ethoxy-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-
• 1-((2'-(1H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxy
• Candesartan Base
• 2-ETHOXY-1-[[2'-(1H-TETRAZOL-5-YL)(1,1'-BIPHENYL)-4-YL]METHYL]-1H-BENZIMIDAZOLE-7-CARBOXYLIC ACID
• Candesartan[CandesartanCilexetilIntermediates]
• Candesartan ( For Candesartan Cilexetil )
• CANDESARTAN
• CV-11974
• CILEXITIL
• 2-Ethoxy-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylic Acid, CV-11974
• 2-Ethoxy-1-[2'-(1-triphenylmethyltetrazol-5-yl)-biphenyl-4-yl-methyl]benzimidazole-7-carboxylicacidcyclohexyl-1-chloroethylcarbonate
• 2-ethoxy-1-[[(2-(1Htetrazol-5-yl)biphenyl-4-yl-) methyl]
• 2-Ethoxy-3-[[4-[2-(1H-tetrazol-5-yl)phenyl]phenyl]
• Atacend
• 2-Ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazol-7-carboxylic acid
• (±)-2-Ethoxy-1-[[2’-(1H-tetrazol-5-y1)[1，l'-biphenyl]-4-y1]methyl]-1H-benzimidazole-7-earboxylic acid
• 3-(2'-Cyano-biphenyl-4-ylMethyl)-2-ethoxy-3H-benzoiMidazole-4-carboxylic acid Me
• 2-ethoxy-1-({4-[2-(1H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl}Methyl)-1H-1,3-benzodiazole-7-carboxylic acid
• Candesartan (Atacand)
• Candesartan 98%
• Candesartan (Candesartan Cilexetil impurity G)
• Candesartan Solution, 1000ppm
• Candesartan Cilexetil Impurity 7(EP Impurity G)
• Candesartan Solution, 100ppm
• tandishatan
• Candesartan Cilexetil EP Impurity G(Candesartan)
• 2-Ethoxy-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylic acid
• 2-Ethoxy-1-[[(2′-(1Htetrazol-5-Yl)Biphenyl-4-Yl-) Methyl]Benzimidazole-7-Carboxylic Acid
• Candesartan (C8)
• 1-((2'-(2H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylic acid
• Candesartan USP/EP/BP
• Cesartan intermediates
• Candesartan EP Impurity G
• Candesartan Cilexetil EP Impurity G (Candesartan Acid)
• Candesartan Impurity -G Candesartan Cilexetil EP Impurity G
• High Quality Intermediates Candesartan CAS: 139481-59-7
• Candesartan (CV 11974)
• candesartan cilexetil impurity1364
• CandesartanQ: What is Candesartan Q: What is the CAS Number of Candesartan Q: What is the storage condition of Candesartan Q: What are the applications of Candesartan
• Candesartan Cilexetil Related Compound G (1-{[2''-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-2-ethoxybe (1087870)
• Candesartan Cilexetil USP Related Compound G
• Candesartan Cilexetil Impurity 7(Candesartan Cilexetil EP Impurity G)
• 3-((2'-(2H-Tetrazol-5-yl)biphenyl-4-yl)methyl)-2-ethoxy-3H-benzo[d]imidazole-4-carboxylic acid [CS-VII (Acid)
• 1-((2'-(1H-Tetrazol-5-yl)-[1,1'-Biphenyl]-4-yl)Methyl)-2-Ethoxy-1H-Benzo[d]iMidazole-7-Carboxylicacid
• Candesartan in methanol
• Candesartan Impurity-G
• 2-ethoxy-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-benzimidazole-7-carboxylic acid
• 2-Ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylic Acid (Candesar
• Candesartan, 10 mM in DMSO
• Candesartan - Bio-X ?
• 139481-59-7