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enniatin A

enniatin A Struktur
2503-13-1
CAS-Nr.
2503-13-1
Englisch Name:
enniatin A
Synonyma:
enniatin A;Lateritin I;N-Methylcyclo(L-Ile-D-Hmb-N-methyl-L-Ile-D-Hmb-N-methyl-L-Ile-D-Hmb-);(3S,6R,9S,12R,15S,18R)-3,9,15-tris[(2S)-butan-2-yl]-4,10,16-trimethyl-6,12,18-tri(propan-2-yl)-1,7,13-trioxa-4,10,16-triazacyclooctadecane-2,5,8,11,14,17-hexone;Cyclo[(2R)- 2-hydroxy-3-methylbutanoyl-N-methyl-L-isoleucyl-(2R)-2-hydroxy-3-methylbutanoyl-N-methyl-L-isoleucyl-(2R)-2-hydroxy-3-methylbutanoyl- N-methyl-L- isoleucyl]
CBNumber:
CB02079105
Summenformel:
C36H63N3O9
Molgewicht:
681.906
MOL-Datei:
2503-13-1.mol

enniatin A Eigenschaften

Schmelzpunkt:
122-124 °C
Siedepunkt:
847.4±65.0 °C(Predicted)
Dichte
1.022±0.06 g/cm3(Predicted)
storage temp. 
-20°C
L?slichkeit
DMSO: soluble10mg/mL
Aggregatzustand
White to off-white crystalline solid.
pka
-0.96±0.70(Predicted)

Sicherheit

Kennzeichnung gef?hrlicher T
R-S?tze: 23/24/25
S-S?tze: 45
RIDADR  2811
WGK Germany  3
HazardClass  6.1(a)
PackingGroup  I
HS Code  2934999090

enniatin A Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Enniatins are cyclohexadepsipeptides commonly isolated from fungi that are known to have antibiotic properties and to induce apoptosis in several cancer lines. Many function as ionophores, forming pores in cellular membranes to allow selective ion transport. Enniatin A is one of four major analogs in the enniatin complex . It has been shown to moderately inhibit acyl-CoA:cholesterol acyltranferase activity in rat liver microsomes with an IC50 value of 22 μM. Enniatin A also demonstrates anthelmintic properties against N. brasiliensis, T. spiralis, and H. spumosa.

Verwenden

Enniatins are a family of depsipeptide ionophores, produced by several Fusarium species. More recently, the effects of the enniatins on acyl-CoA cholesterol transferase, transporters and the selectivity of their antitumour action have received more focus. Enniatin A is one of four major analogues of the enniatin complex and has not previously been available for investigation.

Definition

ChEBI: An enniatin obtained from formal cyclocondensation of three N-[(2R)-2-hydroxy-3-methylbutanoyl]-N-methyl-L-isoleucine units.

enniatin A Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


enniatin A Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 56)Lieferanten
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2503-13-1()Verwandte Suche:


  • enniatin A
  • N-Methylcyclo(L-Ile-D-Hmb-N-methyl-L-Ile-D-Hmb-N-methyl-L-Ile-D-Hmb-)
  • Lateritin I
  • Cyclo[(2R)- 2-hydroxy-3-methylbutanoyl-N-methyl-L-isoleucyl-(2R)-2-hydroxy-3-methylbutanoyl-N-methyl-L-isoleucyl-(2R)-2-hydroxy-3-methylbutanoyl- N-methyl-L- isoleucyl]
  • (3S,6R,9S,12R,15S,18R)-3,9,15-tris[(2S)-butan-2-yl]-4,10,16-trimethyl-6,12,18-tri(propan-2-yl)-1,7,13-trioxa-4,10,16-triazacyclooctadecane-2,5,8,11,14,17-hexone
  • 2503-13-1
  • C36H63N3O9
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