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LUFFARIELLOLIDE

LUFFARIELLOLIDE Struktur
111149-87-2
CAS-Nr.
111149-87-2
Englisch Name:
LUFFARIELLOLIDE
Synonyma:
LUFFARIELLOLIDE;Luffariellolide, phospholipase A2 (PLA2) inhibitor. Agonist at RARalpha;3-[(3E,7E)-4,8-dimethyl-10-(2,6,6-trimethylcyclohexen-1-yl)deca-3,7-dienyl]-2-hydroxy-2H-furan-5-one;4-[(3E,7E)-4,8-Dimethyl-10-(2,6,6-trimethyl-1-cyclohexenyl)-3,7-decadienyl]-5-hydroxyfuran-2(5H)-one;4-[(3E,7E)-4,8-Dimethyl-10-(2,6,6-trimethyl-1-cyclohexen-1-yl)-3,7-decadienyl]-5-hydroxy-2(5H)-furanone;2(5H)-Furanone, 4-[(3E,7E)-4,8-dimethyl-10-(2,6,6-trimethyl-1-cyclohexen-1-yl)-3,7-decadien-1-yl]-5-hydroxy-
CBNumber:
CB0200705
Summenformel:
C25H38O3
Molgewicht:
386.57
MOL-Datei:
111149-87-2.mol

LUFFARIELLOLIDE Eigenschaften

Siedepunkt:
541.7±50.0 °C(Predicted)
Dichte
1.006±0.06 g/cm3(Predicted)
L?slichkeit
DMSO: soluble; Ethanol: soluble
pka
9.98±0.40(Predicted)
Aggregatzustand
Pale yellow oil.
InChI
InChI=1S/C25H38O3/c1-18(11-7-13-21-17-23(26)28-24(21)27)9-6-10-19(2)14-15-22-20(3)12-8-16-25(22,4)5/h10-11,17,24,27H,6-9,12-16H2,1-5H3/b18-11+,19-10+
InChIKey
JPWPYTMXSXYUPG-QZPYEDBESA-N
SMILES
O1C(O)C(CC/C=C(\C)/CC/C=C(\C)/CCC2C(C)(C)CCCC=2C)=CC1=O

Sicherheit

LUFFARIELLOLIDE Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Luffariellolide is a natural sesterterpenoid which reversibly inhibits secretory phospholipase A2 isoforms from bee venom (IC50 = 230 nM) and snake venom, reducing inflammation. It blocks the production of platelet-activating factor in stimulated neutrophils (IC50 = 5 μM). Luffariellolide is also a structural mimic of all-trans retinoic acid (RA) and, at 1 μM, acts as an agonist for the RA receptors RAR α, β, and γ but not for other nuclear receptors. In RA-sensitive cancer cell lines, luffariellolide induces the expression of RAR target genes and inhibits cell growth. It also inhibits the activation of hypoxia-inducible factor by hypoxia (IC50 = 3.6 μM).[Cayman Chemical]

LUFFARIELLOLIDE Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

LUFFARIELLOLIDE Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 44)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 32161 58
Wuhan Topule Biopharmaceutical Co., Ltd 		+8618327326525
 masar@topule.com China 8467 58
Aladdin Scientific 		+1-+1(833)-552-7181
sales@aladdinsci.com United States 52924 58
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627
 info@efebio.com China 9806 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767
 sales@chemegen.com China 11218 58
Energy Chemical 021-58432009 400-005-6266
 marketing1@energy-chemical.com China 44805 58
MedBioPharmaceutical Technology Inc 021-69568360 18916172912
 order@med-bio.cn China 8140 58
Wuhan Topule +86-02787215551 +86-19945035818
 2936752263@qq.com China 8084 58
QUALITY CONTROL SOLUTIONS LTD. 0755-66853366; 13670046396
 ORDERS@QCSRM.COM China 24342 58
amyjetsci 027-59626688 18771149750
 sales@amyjet.com China 3002 58

111149-87-2()Verwandte Suche:

  • LUFFARIELLOLIDE
  • 4-[(3E,7E)-4,8-Dimethyl-10-(2,6,6-trimethyl-1-cyclohexen-1-yl)-3,7-decadienyl]-5-hydroxy-2(5H)-furanone
  • 4-[(3E,7E)-4,8-Dimethyl-10-(2,6,6-trimethyl-1-cyclohexenyl)-3,7-decadienyl]-5-hydroxyfuran-2(5H)-one
  • 3-[(3E,7E)-4,8-dimethyl-10-(2,6,6-trimethylcyclohexen-1-yl)deca-3,7-dienyl]-2-hydroxy-2H-furan-5-one
  • 2(5H)-Furanone, 4-[(3E,7E)-4,8-dimethyl-10-(2,6,6-trimethyl-1-cyclohexen-1-yl)-3,7-decadien-1-yl]-5-hydroxy-
  • Luffariellolide, phospholipase A2 (PLA2) inhibitor. Agonist at RARalpha
  • 111149-87-2
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