MG-115 Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
(S)-
MG115 is a potent and reversible proteasome inhibitor, targeting the chymotryptic site on the 20S particle (K
i = 21 nM). It reduces the degradation of ubiquitin-
conjugated proteins in extracts. (S)-
MG115 also blocks the degradation of long-
and short-
lived proteins in intact cells as well as the proteolytic generation of diverse proteins, including NF-
κB, antigens, and p53. Proteasome inhibitors, including (S)-
MG115, can induce a heat shock response and apoptosis, particularly in cancer cells.
Verwenden
MG-115 is a compound that inhibits the chymotrypsin-like activity of the proteasome.
Allgemeine Beschreibung
Potent reversible proteasome inhibitor (K
i = 21 nM and 35 nM for 20S and 26S proteasome, respectively).
MG-115 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte