3-(4-Pyridyl)indole Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Two Rho-associated kinases (ROCK), ROCK1 and ROCK2, act downstream of the G protein Rho to regulate cytoskeletal stability. The ROCKs play important roles in diverse cellular functions including cell adhesion and proliferation, smooth muscle contraction, and stem cell renewal. 3-(4-Pyridyl)indole is a ROCK1 inhibitor (IC₅₀ = 25 μM) that promotes cell spreading, inhibits membrane blebbing, and induces dissolution of actin stress fibers in a wound healing assay. It also inhibits ROCK2 and PRK2, another Rho-dependent kinase, with similar potency, while inhibiting MSK-1 and PKA with relatively weaker potency.

Chemische Eigenschaften

Yellow Solid

Verwenden

Two Rho-associated kinases (ROCK), ROCK-I and ROCK-II, act downstream of the G protein Rho to regulate cytoskeletal stability. The ROCKs play important roles in diverse cellular functions including cell adhesion and proliferation, smooth muscle contraction, and stem cell renewal. 3-(4-Pyridyl)indole is a ROCK-I inhibitor (IC50 = 25 μM) that promotes cell spreading, inhibits membrane blebbing, and induces dissolution of actin stress fibers in a wound healing assay. It also inhibits ROCK-II and PRK2, another Rho-dependent kinase, with similar potency, while inhibiting MSK-1 and PKA with relatively weaker potency.[Cayman Chemical]

Allgemeine Beschreibung

A cell-permeable indolopyridine compound that acts as a selective, reversible, and ATP-competitive inhibitor of Rho kinase activity with an IC₅₀ of 25 μM. Does not inhibit the activation of Rho kinase nor does it affect the in vitro activities of MLCK, PKCα, and SAPK2a/p38α. Shown to be 5-fold less potent than Y-27632 (Cat. No. 688000; IC₅₀ = ~5 μM), and display a similar specificity profile as H-89 (Cat. No. 371963). Affects cell migration, inhibits blebbing (IC₅₀ = ~ 12 μM in M2 cells), and decreases stress fibers in Bulb 3T3 cells at 50 μM.

3-(4-Pyridyl)indole Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

3-(4-Pyridyl)indole Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	laboratory@coreychem.com	China	30236	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	52924	58
J & K SCIENTIFIC LTD.	010-82848833 400-666-7788	jkinfo@jkchemical.com	China	96815	76
Chemsky（shanghai）International Co.,Ltd.	021-50135380	shchemsky@sina.com	China	32321	50
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51456	80
BOC Sciences	16314854226	info@bocsci.com	United States	9923	65
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9806	58
Biokitchen	021-021-021-31663258 13795219287	donghuanwen@126.com	China	9884	58
Shenzhen Polymeri Biochemical Technology Co., Ltd.	+86-400-002-6226 +86-13028896684;	sales@rrkchem.com	China	57423	58
DC Chemicals	021-58447131 13564518121	sales@dcchemicals.com	China	9409	58

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• 3-(4-Pyridinyl)-
• Rho Kinase Inhibitor III, Rockout
• 1H-Indole, 3-(4-pyridinyl)-
• 3-(4-Pyridinyl)-1H-indole
• 3-(4-Pyridyl)indole
• Rho Kinase Inhibitor III, Rockout - CAS 7272-84-6 - Calbiochem
• Rho Kinase Inhibitor III
• RHO KINASE INHIBITOR III; ROCK INHIBITOR III; ROCKOUT
• ROCK Inhibitor III
• 3-(4-Pyridyl)
• 7272-84-6
• Indole Derivatives
• Inhibitors
• Intermediates & Fine Chemicals
• Pharmaceuticals
• Protein Kinase Inhibitors and Activators