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Disitertide

Disitertide Struktur
272105-42-7
CAS-Nr.
272105-42-7
Englisch Name:
Disitertide
Synonyma:
disitertide;P144 Peptide;TSLDASIIWAMMQN;P144;P144 PEPTIDE;DISITERTIDE, >98%;Disitertide,P144,P144 Peptide, >98%;DisitertideH-Gly-Arg-Gly-Asp-Asn-Pro-OH;L-Asparagine,L-threonyl-L-seryl-L-leucyl-L-a-aspartyl-L-alanyl-L-seryl-L-isoleucyl-L-isoleucyl-L-tryptophyl-L-alanyl-L-methionyl-L-methionyl-L-glutaminyl-;L-Asparagine, L-threonyl-L-seryl-L-leucyl-L-α-aspartyl-L-alanyl-L-seryl-L-isoleucyl-L-isoleucyl-L-tryptophyl-L-alanyl-L-methionyl-L-methionyl-L-glutaminyl-;L-Threonyl-L-seryl-L-leucyl-L-alpha-aspartyl-L-alanyl-L-seryl-L-isoleucyl-L-isoleucyl-L-tryptophyl-L-alanyl-L-methionyl-L-methionyl-L-glutaminyl-L-asparagine
CBNumber:
CB01518504
Summenformel:
C68H109N17O22S2
Molgewicht:
1580.84
MOL-Datei:
272105-42-7.mol

Disitertide Eigenschaften

Siedepunkt:
1968.7±65.0 °C(Predicted)
Dichte
1.327
storage temp. 
Store at -20°C
L?slichkeit
DMSO : ≥ 200 mg/mL (126.52 mM);Water : < 0.1 mg/mL (insoluble)
pka
3.15±0.10(Predicted)
Aggregatzustand
Solid
Farbe
White to off-white
InChIKey
IUYPEUHIWDMJLM-INGCBPSVNA-N

Sicherheit

Disitertide Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Disitertide is an inhibitor of TGF-β1. It prevents TGF-β1-dependent inhibition of MV1Lu proliferation in vitro and markedly reduces binding of TGF-β1 to its receptors. Disitertide blocks TGF-β1-dependent stimulation of a reporter gene under the control of human α2(I) collagen promoter. Treatment with Disitertide at low doses causes a significant inhibition of HSC activation and a marked reduction in liver fibrosis in a rat model of chronic exposure to CCl4. A dose as low as 70 μg of the 15-mer peptide Disitertide, given to rats (300 g body weight) on alternate days, decreases fibrogenesis significantly during chronic exposure to CCl4.

Disitertide Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Disitertide Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

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272105-42-7()Verwandte Suche:

  • disitertide
  • L-Threonyl-L-seryl-L-leucyl-L-alpha-aspartyl-L-alanyl-L-seryl-L-isoleucyl-L-isoleucyl-L-tryptophyl-L-alanyl-L-methionyl-L-methionyl-L-glutaminyl-L-asparagine
  • P144 Peptide
  • P144;P144 PEPTIDE
  • TSLDASIIWAMMQN
  • DISITERTIDE, >98%
  • Disitertide,P144,P144 Peptide, >98%
  • L-Asparagine, L-threonyl-L-seryl-L-leucyl-L-α-aspartyl-L-alanyl-L-seryl-L-isoleucyl-L-isoleucyl-L-tryptophyl-L-alanyl-L-methionyl-L-methionyl-L-glutaminyl-
  • DisitertideH-Gly-Arg-Gly-Asp-Asn-Pro-OH
  • L-Asparagine,L-threonyl-L-seryl-L-leucyl-L-a-aspartyl-L-alanyl-L-seryl-L-isoleucyl-L-isoleucyl-L-tryptophyl-L-alanyl-L-methionyl-L-methionyl-L-glutaminyl-
  • 272105-42-7
  • C68H109N17O22S2
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