4,5-Dimethoxy-1-cyanobenzocyclobutane
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- CAS-Nr.
- 35202-54-1
- Englisch Name:
- 4,5-Dimethoxy-1-cyanobenzocyclobutane
- Synonyma:
- 4,5-Dimethoxy-1-benzocyclobutenecarbonitrile;4,5-dimethoxy-1,2-dihydrocyclobutabenzene-1-carbonitrile;3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-triene-7-carbonitrile;NSC 154410;Ivabradine Impurity 79;Ivabradine Impurity 89;5-Dimethoxy-1-cyanobenzocyclobutane;1-Cyano-4,5-dimethoxybenzocyclobutene;4,5-Dimethoxy-1-cyanobenzocyclobutane;4,5-Dimethoxy-1-benzocyclobutenecarbonitrile>
- CBNumber:
- CB01503975
- Summenformel:
- C11H11NO2
- Molgewicht:
- 189.21
- MOL-Datei:
- 35202-54-1.mol
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4,5-Dimethoxy-1-cyanobenzocyclobutane Eigenschaften
- Schmelzpunkt:
- 83-84 °C
- Siedepunkt:
- 345.9±42.0 °C(Predicted)
- Dichte
- 1.18
- Dampfdruck
- 0.004Pa at 25℃
- storage temp.
- Sealed in dry,Room Temperature
- L?slichkeit
- DMSO, Methanol
- Aggregatzustand
- Solid
- Farbe
- Light Brown
- LogP
- 1.22 at 30℃ and pH7
- CAS Datenbank
- 35202-54-1(CAS DataBase Reference)
4,5-Dimethoxy-1-cyanobenzocyclobutane Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
4,5-Dimethoxy-1-cyanobenzocyclobutane is used in the preparation of selective bradycardic agents.
Synthese
NaNH2 (39.0 g,
1.0 mol) was added in portions to a solution of hydrocinnamonitrile
8 (224.0 g, 0.83 mol) in liquid ammonia at -45°C, and the reaction
mixture was stirred at -45 °C for 2 h. After evaporation of the excess
NH3, NH4Cl (20.0 g) and water (1000 mL) were added in portions.
After standing at room temperature, greyish crystals separated
and were collected and recrystallised with ethanol to give 4,5-Dimethoxy-1-cyanobenzocyclobutane as a colourless powder. Yield 116.5 g (74%).
4,5-Dimethoxy-1-cyanobenzocyclobutane Upstream-Materialien And Downstream Produkte
Upstream-Materialien
(E)-3-(3,4-Dimethoxyphenyl)acrylonitril
3-(3,4-Dimethoxyphenyl)propanenitrile
3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-one
3-(2-BROMO-4,5-DIMETHOXYPHENYL)PROPANENITRILE
4,5-Dimethoxy-2-methylbenzaldehyd
4,5-Dibromveratrol
2-Bromo-4,5-Dimethoxybenzyl Bromide
4-Bromveratrol
3,4-Dimethoxybenzylalkohol
Veratrumaldehyd
1,2-Dimethoxybenzol
Downstream Produkte
4,5-Dimethoxy-1-cyanobenzocyclobutane Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 273)Lieferanten
35202-54-1()Verwandte Suche:
- 4,5-Dimethoxy-1-cyanobenzocyclobutane
- Bicyclo[4.2.0]octa-1,3,5-triene-7-carbonitrile,3,4-diMethoxy-
- 4,5-DiMethxoy-1,2-dihydrocyclobutabenzene-1-carbonitrile
- 2-cyclobutyl-2-(3,4-diMethoxyphenyl)acetonitrile
- 3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-triene-8-carbonitrile
- 1,2-Dihydro-4,5-diMethoxybenzocyclobutene-1-carbonitrile
- NSC 154410
- 1-Cyano-4,5-dimethoxybenzocyclobutene
- 4,5-diMethoxy-1-cyanobenzocyclobutane (For Ivabradine)
- 4,5-Dimethoxy-1-cyanobenzocyclobutane CAS 35202-54-1
- 4,5-Dimethoxy-1-benzocyclobutenecarbonitrile>
- 5-Dimethoxy-1-cyanobenzocyclobutane
- Ivabradine Impurity 79
- 3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-triene-7-carbonitrile
- 4,5-Dimethoxy-1-benzocyclobutenecarbonitrile
- 4,5-dimethoxy-1,2-dihydrocyclobutabenzene-1-carbonitrile
- Ivabradine Impurity 89
- 35202-54-1
