Olopatadine hydrochloride
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- CAS-Nr.
- 140462-76-6
- Englisch Name:
- Olopatadine hydrochloride
- Synonyma:
- OLOPATADINE HCL;Patanol;Olopatadin HCL;OLAPATADINE HCL;Olopatadine Hydrochlorde;Opatanol;AL-4943A;ALO4943A;OLOPATDINEHYDROCHLORIDE;Olatadine hydrochloride
- CBNumber:
- CB0144403
- Summenformel:
- C21H24ClNO3
- Molgewicht:
- 373.88
- MOL-Datei:
- 140462-76-6.mol
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Olopatadine hydrochloride Eigenschaften
- Schmelzpunkt:
- 242-245?C
- storage temp.
- Inert atmosphere,Room Temperature
- L?slichkeit
- H2O: ≥20mg/mL
- Aggregatzustand
- solid
- Farbe
- White to Light yellow
- Merck
- 14,6840
- BCS Class
- 3(CLogP), 1
(LogP)
- InChI
- InChI=1S/C21H23NO3.ClH/c1-22(2)11-5-8-18-17-7-4-3-6-16(17)14-25-20-10-9-15(12-19(18)20)13-21(23)24;/h3-4,6-10,12H,5,11,13-14H2,1-2H3,(H,23,24);1H/b18-8-;
- InChIKey
- HVRLZEKDTUEKQH-NOILCQHBSA-N
- SMILES
- C(=C1/C2=CC=CC=C2COC2C=CC(CC(=O)O)=CC/1=2)\CCN(C)C.Cl
- CAS Datenbank
- 140462-76-6(CAS DataBase Reference)
Olopatadine hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Olopatadine hydrochloride is an ophthalmic antihistamine that inhibits release of histamine from mast cells and is a relatively selective histamine H1 antagonist. It inhibits type 1 immediate hypersensitivity reactions. Olopatadine hydrochloride is indicated in the temporary relief of itching caused by allergic conjunctivitis. H1 antagonists have an established and valued place in the symptomatic treatment of various immediate hypersensitivity reactions. In addition, the central properties of some of the series are of therapeutic value for suppressing motion sickness or for sedation.
Chemische Eigenschaften
White Solid
Verwenden
Olopatadine hydrochloride is a potent, selective antagonist of the H1 histamine receptor (Ki = 16-41.1 nM), with much lower affinities for the H2 and H3 receptors (Ki = 43.4 and 172 μM, respectively). It blocks histamine-induced phosphoinositide turnover in isolated cells (IC50 = 9.5-39.9 nM) and prevents passive cutaneous anaphylaxis in rats (ED50 = 49 μg/kg) and anaphylactic bronchoconstriction in guinea pigs (ID50 = 30 μg/kg). Olopatadine is effective in treating allergic rhinitis and conjunctivitis. It also suppresses itch in patients with well-controlled chronic urticaria. In humans, this antihistamine does not cause cognitive or psychomotor impairment at therapeutic doses.[Cayman Chemical]
Olopatadine hydrochloride Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Olopatadine hydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 486)Lieferanten
140462-76-6()Verwandte Suche:
- OLOPATADINE HYDROCHLORIDE
- OLOPATDINEHYDROCHLORIDE
- OLOPATADINE HYDROCHLORIDE AND THE INTERMEDIATES
- (Z)-11-[3-(Dimethylamino)propylidene]-6,11-dihydrodibenz[b,e]oxepin-2-acetic acid hydrochloride
- Olopatadine Hydrochloride (150 mg)
- Olopatadin HCL (DFM Gr)INN
- (11Z)-11-[3-(Dimethylamino)propylidene]-6,11-dihydrodibenz[b,e]oxepin-2-acetic acid hydrochloride
- AL-4943A
- Opatanol
- (11Z)-11-[3-(dimethylamino)propylidene]-6,11-dihydro-dibenz[b,e]oxepin-2-acetic acid, hydrochloride (1:1)
- (Z)-2-(11-(3-(dimethylamino)propylidene)-6,11-dihydrodibenzo[b,e]oxepin-2-yl)acetic acid hydrochloride
- Olopatadine, as Hydrochloride
- ALO4943A
- Dibenz[b,e]oxepin-2-acetic acid, 11-[3-(dimethylamino)propylidene]-6,11-dihydro-, hydrochloride (1:1), (11Z)-
- Olopatadine hydrochloride, 99%, a selective H1 receptor antagonist
- OlopatadineHydrochloride>
- Olopatadine hydrochloride USP/EP/BP
- Olopatadine HCl (ALO4943A
- Olopatadine hydrochlorideQ: What is
Olopatadine hydrochloride Q: What is the CAS Number of
Olopatadine hydrochloride Q: What is the storage condition of
Olopatadine hydrochloride
- Olopatadine Hydrochloride (1478403)
- OLOPATADINE HCL
- OLAPATADINE HCL
- Olopatadin HCL
- Patanol
- Olopatadine Hydrochlorde
- Olatadine hydrochloride
- 140462-76-6
- C21H23NO3ClH
- C21H23NO3HCl
- API
- Opatanol, Pataday, Patanase, Allelock
- APIs
- Olopatadine
- Amines
- Heterocycles
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Pharmaceutical material and intermeidates
