BI-0474

2750570-55-7

CAS-Nr.: 2750570-55-7

Englisch Name:: BI-0474

Synonyma:: BI-0474;Benzo[b]thiophene-3-carbonitrile, 2-amino-4-[3-[6-[(2S)-2,4-dimethyl-1-piperazinyl]-4-[4-(1-oxo-2-propen-1-yl)-1-piperazinyl]-2-pyridinyl]-1,2,4-oxadiazol-5-yl]-4,5,6,7-tetrahydro-4-methyl-, (4S)-

CBNumber:: CB012245556

Summenformel:: C30H37N9O2S

Molgewicht:: 587.74

MOL-Datei:: 2750570-55-7.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 26

BI-0474 Eigenschaften

Siedepunkt:: 879.4±75.0 °C(Predicted)

Dichte: 1.38±0.1 g/cm3(Predicted)

pka: 7.13±0.70(Predicted)

Aggregatzustand: Solid

Farbe: White to off-white

InChIKey: CKAMBYUZKWQCKJ-ADSBAMQRSA-N

SMILES: C12CCC[C@@](C3ON=C(C4=NC(N5CCN(C)C[C@@H]5C)=CC(N5CCN(C(=O)C=C)CC5)=C4)N=3)(C)C=1C(C#N)=C(N)S2

Sicherheit

BI-0474 Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

BI-0474 is a potent KRAS^G12C inhibitor with an IC₅₀ value of 7.0 nM for the GDP-KRAS::SOS1 protein-protein interaction. It exhibits good anti-proliferative activity against NCI-H358 cells carrying the G12C mutation. BI-0474 also shows good anti-tumour activity in non-small cell lung cancer xenograft models.

BI-0474 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

BI-0474 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 26)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Hubei Chuchang Biotech Co., Ltd.	+undefined15623860702	info@chuchangbiotech.com	China	212	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32161	58
Wuhan Jingkang en Biomedical Technology Co., Ltd	+8613720134139	orders@jknbiochem.com	China	5221	58
Hubei Chuchang Chemical Co., Ltd	18; 15623560702	Joy.Ren@aliyun.com	China	159	58
Changzhou Borl Biotechnology Co.,LTD	13606124132;13656121842	luyan0021@163.com	China	219	58
ShangHai Caerulum Pharma Discovery Co., Ltd.	18149758185 18149758185	sales-cpd@caerulumpharma.com	China	3466	58
Shanghai Lollane Biological Technology Co.,Ltd.	021-52996696，15000506266 15000506266		China	4575	55
ShangHai Angti Biotechnology Co., Ltd.	13764913901	info@angtibio.com	China	5037	55
ShangHai Biochempartner Co.,Ltd	177-54423994 17754423994	2853530910@QQ.com	China	8011	62
Shanghai Rechem science Co., Ltd.	21-31433387 15618786686	sales@rechemscience.com	China	2986	58

Benzo[b]thiophene-3-carbonitrile, 2-amino-4-[3-[6-[(2S)-2,4-dimethyl-1-piperazinyl]-4-[4-(1-oxo-2-propen-1-yl)-1-piperazinyl]-2-pyridinyl]-1,2,4-oxadiazol-5-yl]-4,5,6,7-tetrahydro-4-methyl-, (4S)-
BI-0474
2750570-55-7
C30H37N9O2S

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