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Euphorbiasteroid

Euphorbiasteroid Struktur
28649-59-4
CAS-Nr.
28649-59-4
Englisch Name:
Euphorbiasteroid
Synonyma:
Euphorbia factor L1;Daughter son sterol;Euphorbiasteroid（EuphorbiaFactor L1）;6,20-Epoxylathyrol phenylacetate diacetate;Euphorbiasteroid, 98%, from Leptochloa chinensis (L.) Nees;(1aS,2E,4aR,6S,7S,7aS,8S,9R,11aS)-4a,8-bis(acetyloxy)-1,1,3,...;Benzeneacetic acid 4a,8-bis(acetyloxy)-1,1a,4,4a,5,6,7,7a,8,10,11,11a-dodecahydro-1,1,3,6-tetramethyl-4-oxospiro[9H-cyclopenta[a]cyclopropa[f]cycloundecene-9,2'-oxiran]-7-yl ester;(1aR,4aR,6S,7S,7aR,8S,9R,11aS,E)-1,1,3,6-Tetramethyl-4-oxo-7-(2-phenylacetoxy)-1,1a,4,6,7,7a,8,10,11,11a-decahydrospiro[cyclopenta[a]cyclopropa[f][11]annulene-9,2'-oxiran]-4a,8(5H)-diyl diacetate;(1aS,2E,4aR,6S,7S,7aS,8S,9R,11aS)-4a,8-bis(acetyloxy)-1,1,3,6-tetramethyl-4-oxo-1,1a,4,4a,5,6,7,7a,8,10,11,11a-dodecahydrospiro[cyclopenta[a]cyclopropa[f][11]annulene-9,2'-oxiran]-7-yl phenylacetate;Benzeneacetic acid (1aR,2'R,2E,4aR,6S,7S,7aR,8S,11aS)-4a,8-bis(acetyloxy)-1,1a,4,4a,5,6,7,7a,8,10,11,11a-dodecahydro-1,1,3,6-tetramethyl-4-oxospiro[9H-cyclopenta[a]cyclopropa[f]cycloundecene-9,2'-oxiran]-7-yl ester
CBNumber:
CB01118210
Summenformel:
C32H40O8
Molgewicht:
552.66
MOL-Datei:
28649-59-4.mol

Euphorbiasteroid Eigenschaften

Schmelzpunkt:
199～200℃
Siedepunkt:
633.1±55.0 °C(Predicted)
Dichte
1.23
storage temp. 
4°C, protect from light
L?slichkeit
DMSO:15.0(Max Conc. mg/mL);27.14(Max Conc. mM)
DMF:5.0(Max Conc. mg/mL);9.05(Max Conc. mM)
Aggregatzustand
A crystalline solid

Sicherheit

S-S?tze: 24/25
HS Code  29061990

Euphorbiasteroid Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Euphorbiasteroid is a compound used to induce HL-60 cells to apoptosis via promoting Bcl/Bax apoptotic signaling pathway in a dose-dependent manner.

Biologische Funktion

Euphorbiasteroid, Euphorbia Factor L1 (EFL1) to be specific, with a tricyclic terpenoid skeleton, consisting of fused five-, eleven- and three-membered rings, is a diterpenoid isolated from the seeds of Euhporbia lathyris L. It is reported EFL1 could be helpful to reduces the expression of Bcl-2, PI3K, AKT and mTOR protein and mRNA, upregulates cleaved caspase-9 and caspase-3 levels, but shows no effect on pro-caspase-9 and pro-caspase-3. EFL1 also could induce apoptosis, and possess anticancer, antiadipogenesis, antiosteoclastogenesis and multi-drug resistance-modulating effect.
Euphorbiasteroid showed effects on adipogenesis of 3T3-L1 pre-adipocytes. Euphorbiasteroid also has the potential to reverse P-glycoprotein (P-gp)-mediated multi-drug resistance (MDR) by using the drug-sensitive human sarcoma cell line MES-SA and its MDR counterpart MES-SA/Dx5.EFL1 inhibited osteoclastogenesis and induced osteoclast apoptosis. Euphorbiasteroid suppressed osteoclast formation and bone resorption at both initial and terminal differentiation stages.

Euphorbiasteroid Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Euphorbiasteroid Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 131)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hebei Weibang Biotechnology Co., Ltd 		+8615531157085
 abby@weibangbio.com China 8807 58
Hebei Mojin Biotechnology Co., Ltd 		+86 13288715578 +8613288715578
 sales@hbmojin.com China 12834 58
Hebei Fengjia New Material Co., Ltd 		+86-0311-87836622 +86-17333973358
 sales06@hbduling.cn China 8051 58
Shanghai Zheyan Biotech Co., Ltd. 		18017610038
zheyansh@163.com CHINA 3619 58
career henan chemical co 		+86-0371-86658258 +8613203830695
 sales@coreychem.com China 29880 58
Chengdu GLP biotechnology Co Ltd 		028-87075086 13350802083
 scglp@glp-china.com CHINA 1824 58
Chengdu Biopurify Phytochemicals Ltd. 		+8618080483897
 sales@biopurify.com China 3772 58
Hubei Jusheng Technology Co.,Ltd. 		18871490254
linda@hubeijusheng.com CHINA 28172 58
Chongqing Chemdad Co., Ltd 		+86-023-6139-8061 +86-86-13650506873
 sales@chemdad.com China 39894 58
Shanghai Standard Technology Co., Ltd. 		18502101150
ft-sales@nature-standard.com CHINA 1923 58

28649-59-4()Verwandte Suche:

  • Daughter son sterol
  • 6,20-Epoxylathyrol phenylacetate diacetate
  • Benzeneacetic acid (1aR,2'R,2E,4aR,6S,7S,7aR,8S,11aS)-4a,8-bis(acetyloxy)-1,1a,4,4a,5,6,7,7a,8,10,11,11a-dodecahydro-1,1,3,6-tetramethyl-4-oxospiro[9H-cyclopenta[a]cyclopropa[f]cycloundecene-9,2'-oxiran]-7-yl ester
  • Benzeneacetic acid 4a,8-bis(acetyloxy)-1,1a,4,4a,5,6,7,7a,8,10,11,11a-dodecahydro-1,1,3,6-tetramethyl-4-oxospiro[9H-cyclopenta[a]cyclopropa[f]cycloundecene-9,2'-oxiran]-7-yl ester
  • Euphorbia factor L1
  • Euphorbiasteroid, 98%, from Leptochloa chinensis (L.) Nees
  • (1aS,2E,4aR,6S,7S,7aS,8S,9R,11aS)-4a,8-bis(acetyloxy)-1,1,3,6-tetramethyl-4-oxo-1,1a,4,4a,5,6,7,7a,8,10,11,11a-dodecahydrospiro[cyclopenta[a]cyclopropa[f][11]annulene-9,2'-oxiran]-7-yl phenylacetate
  • (1aS,2E,4aR,6S,7S,7aS,8S,9R,11aS)-4a,8-bis(acetyloxy)-1,1,3,...
  • Euphorbiasteroid（EuphorbiaFactor L1）
  • (1aR,4aR,6S,7S,7aR,8S,9R,11aS,E)-1,1,3,6-Tetramethyl-4-oxo-7-(2-phenylacetoxy)-1,1a,4,6,7,7a,8,10,11,11a-decahydrospiro[cyclopenta[a]cyclopropa[f][11]annulene-9,2'-oxiran]-4a,8(5H)-diyl diacetate
  • 28649-59-4
  • 32H40O8
  • C32H40O8
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