N-Methyl-1H-Indole-5-EthaneSulphonamide
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- CAS-Nr.
- 98623-50-8
- Englisch Name:
- N-Methyl-1H-Indole-5-EthaneSulphonamide
- Synonyma:
- 2-(1H-indol-5-yl)-N-methylethane-1-sulfonamide;ratriptanImpurity5;N-Methyl-1H-Indole-5-EthaneSulphomide;N-Methyl-1H-indole-5-ethanesulfonamide;N-Methyl-1H-Indole-5-EthaneSulphonamide;1H-Indole-5-ethanesulfonamide, N-methyl-;2-(1H-indol-5-yl)-N-MethylethanesulfonaMide;N-Methyl-1H-indole-5-ethanesulfonamide, >=98%;2 - (1h-indole-5-yl) - n-methylethyl-1-sulfonamide;2-(1H-Indol-5-yl) -ethanesulfonic acid methyl amide
- CBNumber:
- CB01023956
- Summenformel:
- C11H14N2O2S
- Molgewicht:
- 238.31
- MOL-Datei:
- 98623-50-8.mol
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N-Methyl-1H-Indole-5-EthaneSulphonamide Eigenschaften
- Schmelzpunkt:
- 124-125°C
- Siedepunkt:
- 458.4±47.0 °C(Predicted)
- Dichte
- 1.316±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- L?slichkeit
- DMSO (Slightly), Methanol (Slightly)
- Aggregatzustand
- Solid
- pka
- 11.52±0.40(Predicted)
- Farbe
- White to Off-White
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
| H317 |
Kann allergische Hautreaktionen verursachen. |
Sensibilisierung der Haut |
Kategorie 1A |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P261, P272, P280, P302+P352,P333+P313, P321, P363, P501 |
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| Sicherheit |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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N-Methyl-1H-Indole-5-EthaneSulphonamide Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
N-Methyl-1H-indole-5-ethanesulfonamide is used as a reagent in the synthesis of Naratriptan Hydrochloride (N378730); a triptan drug used for the treatment of migraine headaches.
Synthese
At 40-45 ℃ (hydrogen pressure: 3-4 kg/cm2), 2-(3-Phenylsulf-anyl-1H-indol-5-yl)-ethanesulfonic acidmethylamide (14) (5 g, 0.014 mol) was hydrogenated in ethanol: water (7:3) (40 ml) in an autoclave for 10 h. After that, the reaction mass was cooled to room temperature, followed by removing the catalyst through filtering. The filtrate was distilled out to get N-Methyl-1H-Indole-5-EthaneSulphonamide.
N-Methyl-1H-Indole-5-EthaneSulphonamide Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
N-Methyl-1H-Indole-5-EthaneSulphonamide Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 70)Lieferanten
- N-Methyl-1H-Indole-5-EthaneSulphonamide
- N-Methyl-1H-indole-5-ethanesulfonamide
- 2-(1H-indol-5-yl)-N-MethylethanesulfonaMide
- N-Methyl-1H-indole-5-ethanesulfonamide, >=98%
- N-Methyl-1H-Indole-5-EthaneSulphomide
- 1H-Indole-5-ethanesulfonamide, N-methyl-
- 2 - (1h-indole-5-yl) - n-methylethyl-1-sulfonamide
- 2-(1H-indol-5-yl)-N-methylethane-1-sulfonamide
- ratriptanImpurity5
- N-Methyl-1H-indole-5-ethanesulfonamide (2-(1H-Indol-5-yl)-N-methylethanesulfonamide)
- 2-(1H-Indol-5-yl) -ethanesulfonic acid methyl amide
- 98623-50-8
