色酚AS-E磷酸鹽
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- CAS號:
- 18228-17-6
- 英文名:
- NAPHTHOL AS-E PHOSPHATE
- 英文別名:
- kg-501;NASEP;KD-501;NAPHTHOL AS-E PHOSPHATE;2-naphthol-AS-E-phosphate;KG-501(NaphtholAS-Ephosphate);KG-501 (2-naphthol-AS-E-phosphate);NAPHTHOL AS-E PHOSPHATE NAPHTHOL FREE;NAPHTHOL AS-E-PHOSPHATE, FOR HISTOLOGY;2-NAPHTHOL-AS-E-PHOSPHATE;NAPHTHOL AS-E PHOSPHATE
- 中文名:
- 色酚AS-E磷酸鹽
- 中文別名:
- 萘酚AS-E磷酸酯;色酚AS-E磷酸鹽;KG-501 磷酸萘酚AS-E;磷酸萘酚AS-E,萘酚AS-E磷酸酯,;KG-501(2-萘酚-AS-E-磷酸鹽);3-((4-氯苯基)氨基甲?；?萘-2-基磷酸二氫鹽
- CBNumber:
- CB9737978
- 分子式:
- C17H13ClNO5P
- 分子量:
- 377.72
- MOL File:
- 18228-17-6.mol
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色酚AS-E磷酸鹽化學(xué)性質(zhì)
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密度:
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1.567±0.06 g/cm3(Predicted)
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儲存條件:
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Keep in dark place,Inert atmosphere,2-8°C
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溶解度:
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DMSO: soluble
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形態(tài):
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A crystalline solid
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酸度系數(shù)(pKa):
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1.04±0.30(Predicted)
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顏色:
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White to light yellow
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BRN:
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6664478
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色酚AS-E磷酸鹽性質(zhì)、用途與生產(chǎn)工藝
KG-501 (2-naphthol-AS-E-phosphate)是CREB抑制劑，破壞依賴于CREB的轉(zhuǎn)錄（Ki=10 μM）和CREB：CBP的相互作用（Ki=50 μM）。它還能破壞磷酸化CREB(Ser-133)與KIX的結(jié)合，Ki約為90 μM。
KG-501通過阻止CREB:CBP相互作用，抑制（或部分抑制）了cAMP相關(guān)基因的誘導(dǎo)。KG-501抑制了神經(jīng)突增生、突觸發(fā)生和減少M(fèi)AP2+神經(jīng)細(xì)胞。
KG-501抑制CREB、CCL2的表達(dá)和ERK磷酸化，同時(shí)顯著地降低了cAMP水平。CREB可能通過cAMP/ERKadjustment pathway有助于對抗神經(jīng)炎癥，從而保護(hù)神經(jīng)。KG-501顯著地促進(jìn)了經(jīng)氧化偶氮甲烷（AOM）處理的小鼠模型的神經(jīng)功能，降低了皮質(zhì)中ERK磷酸化水平和cAMP的濃度。
色酚AS-E磷酸鹽
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS編號 | 包裝 | 價(jià)格 |
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| 2024/11/08 | HY-103299 | KG-501 | | 1 mg | 250元 |
| 2024/11/08 | HY-103299 | 色酚AS-E磷酸鹽
KG-501 | 18228-17-6 | 5mg | 500元 |
18228-17-6, 色酚AS-E磷酸鹽 相關(guān)搜索:
- API
- Substrates
- 抑制劑
- 藥靶配體
- Substrates by Enzyme
- Enzymes, Inhibitors, and Substrates
- Enzyme Substrates
- Biochemicals and Reagents
- BioChemical
- C17H13ClNO5P
- 8228-17-6
- 18228-27-6
- KG-501(2-萘酚-AS-E-磷酸鹽)
- 3-((4-氯苯基)氨基甲?；?萘-2-基磷酸二氫鹽
- 磷酸萘酚AS-E,萘酚AS-E磷酸酯,
- KG-501 磷酸萘酚AS-E
- 萘酚AS-E磷酸酯
- 色酚AS-E磷酸鹽
- 18228-17-6
- Epigenetic Reader Domain,inhibit,Inhibitor,KG 501,Naphthol AS-E,KG501,KG-501
- kg-501
- KG-501(NaphtholAS-Ephosphate)
- 2-NAPHTHOL-AS-E-PHOSPHATE;NAPHTHOL AS-E PHOSPHATE
- 2-naphthol-AS-E-phosphate
- NASEP
- N-(4-CHLOROPHENYL)-3-(PHOSPHONOOXY)NAPHTHALENE-2-CARBOXAMIDE; KG-501; NASEP;NAPHTHOL AS-E PHOSPHATE;KG501;KG 501
- KG-501 (2-naphthol-AS-E-phosphate)
- 2-Naphthalenecarboxamide, N-(4-chlorophenyl)-3-(phosphonooxy)-
- 3-hydroxy-2-(hydroxymethyl)-2-methyl-1-phenyl-1-propanone
- KD-501
- [3-[(4-chlorophenyl)carbamoyl]naphthalen-2-yl] dihydrogen phosphate
- [3-[(4-chlorophenyl)carbamoyl]-2-naphthyl] dihydrogen phosphate
- N-(4-Chlorophenyl)-3-phosphonooxy-2-naphthalenecarboxamide
- NAPHTHOL AS-E PHOSPHATE NAPHTHOL FREE
- NAPHTHOL AS-E-PHOSPHATE, FOR HISTOLOGY
- N-(4-chlorophenyl)-3-(phosphonooxy)naphthalene-2-carboxamide
- NAPHTHOL AS-E PHOSPHATE