硫酸奧西那林
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- CAS號:
- 5874-97-5
- 英文名:
- Orciprenaline sulfate
- 英文別名:
- METAPROTERENOL SULFATE;alupent;alotec;th-152;metaprel;Astmopent;novasmasol;ORCIPRENALINE SULFATE;dl-Orciprenaline sulfate;METAPROTERENOLSULFATE,USP
- 中文名:
- 硫酸奧西那林
- 中文別名:
- 硫酸異丙喘寧;硫酸奧西那林;硫酸奧昔帕林;異丙喘寧硫酸鹽;奧西那林硫酸鹽;硫酸奧腎上腺素;奧西那林半硫酸鹽;硫酸奧西那林雜質(zhì);硫酸奧西那林-D6;硫酸奧西那林 標(biāo)準(zhǔn)品
- CBNumber:
- CB7226328
- 分子式:
- C22H36N2O10S
- 分子量:
- 520.59
- MOL File:
- 5874-97-5.mol
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硫酸奧西那林化學(xué)性質(zhì)
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熔點:
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202-203°
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儲存條件:
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2-8°C
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溶解度:
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Freely soluble in water, slightly soluble in ethanol (96 per cent), practically insoluble in methylene chloride.
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形態(tài):
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Solid
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顏色:
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White to Off-White
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穩(wěn)定性:
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Hygroscopic
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硫酸奧西那林性質(zhì)、用途與生產(chǎn)工藝
Metaproterenol hemisulfate (Orciprenaline hemisulfate) 是一種直接作用的擬交感神經(jīng)藥，是 β2-腎上腺素能受體 (β2AR) 激動劑，其 IC50 為 68 nM。Metaproterenol hemisulfate 還具有抗炎活性。
IC50: 68 nM (β2-adrenergic receptor)
Metaproterenol (10 μM; 74 hours; THP-1 cells and bone marrow macrophages) treatment enhances β-arrestin2 and its interaction with IκBα in high glucose-induced THP-1 cells and bone marrow macrophages.
Metaproterenol (10 μM; 74 hours; THP-1 cells and bone marrow macrophages) treatment leads to downregulation of NF-κB in high glucose-induced THP-1 cells and bone marrow macrophages.
Western Blot Analysis
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Cell Line:
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THP-1 cells and bone marrow macrophages
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Concentration:
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10 μM
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Incubation Time:
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74 hours
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Result:
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Enhanced β-arrestin2 and its interaction with IκBα.
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RT-PCR
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Cell Line:
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THP-1 cells and bone marrow macrophages
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Concentration:
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10 μM
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Incubation Time:
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74 hours
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Result:
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Led to downregulation of NF-κB.
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Treatment of Zucker diabetic fatty rats with Metaproterenol for 12 weeks attenuates monocyte activation as well as pro-inflammatory and pro-fibrotic responses in the kidneys and heart. Thus, Metaproterenol might has protective effects against diabetic renal and cardiovascular complications.
硫酸奧西那林
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS編號 | 包裝 | 價格 |
|---|
| 2025/02/08 | HY-B1276 | 硫酸奧西那林
Metaproterenol hemisulfate | 5874-97-5 | 5 mg | 171元 |
| 2025/02/08 | HY-B1276 | 硫酸奧西那林
Metaproterenol hemisulfate | 5874-97-5 | 10mM * 1mLin DMSO | 188元 |
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- 5874-97-5
- Metaproterenol hemisulfate, 10 mM in DMSO
- 1,3-Benzenediol, 5-[1-hydroxy-2-[(1-methylethyl)amino]ethyl]-, sulfate (2:1)
- Inhibitor,Beta Receptor,Metaproterenol hemisulfate,inhibit,Orciprenaline hemisulfate,Adrenergic Receptor
- METAPROTERENOL SULFATE
- alupent
- Metaproterenol Sulfate (1395500)
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