Z-D-SER(TBU)-OME synthesis
- Product Name:Z-D-SER(TBU)-OME
- CAS Number:93204-37-6
- Molecular formula:C16H23NO5
- Molecular Weight:309.36
154632-86-7
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75-65-0
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93204-37-6
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Yield:93204-37-6 71%
Reaction Conditions:
with boron trifluoride diethyl etherate in chloroform at 0 - 20; for 18 h;
Steps:
12.5 Step 5) (2R)-2-(benzyloxycarbonylamino)-3-tert-butoxypropionic acid methyl ester
O1-benzyl O2-methyl(2R)-aziridine-1,2-dicarboxylate (15.5 g, 66 mmol) was dissolved in chloroform(160 mL), tert-butanol (270 mL) was added. At 0 ° C, a solution of boron trifluoride diethyl ether (16 mL, 132 mmol) was slowly added dropwise. The temperature was returned to room temperature and reacted for 18 hours. Add water (100 mL) to quench the reaction, dispense, The organic phase is dried over anhydrous sodium sulfate. Concentrated by suction filtration, and the residue was subjected to silica gel column chromatography [Petroleum ether / ethyl acetate (v/v) = 5/1] purification, the title compound was obtained (14.5 g, yield 71%). It is a white solid.
References:
CN109928971,2019,A Location in patent:Paragraph 0368; 0381; 0382; 0383; 0384
93204-36-5
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115-11-7
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93204-37-6
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501-53-1
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93204-37-6
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$45.00/50mg