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德倫環(huán)烷

德倫環(huán)烷, 120444-71-5, 結(jié)構(gòu)式
德倫環(huán)烷
CAS號:
120444-71-5
英文名:
DERAMCICLANE
英文別名:
EGIS-3886;DERAMCLCLANE;DERAMCICLANE;DERAMCICLANE ISO 9001：2015 REACH;N,N-Dimethyl-2-[[(1R,2S,4R)-1,7,7-trimethyl-2-phenylbicyclo[2.2.1]hept-2-yl]oxy]ethanamine;N,N-dimethyl-2-(((1S,2S,4R)-1,7,7-trimethyl-2-phenylbicyclo[2.2.1]heptan-2-yl)oxy)ethanamine;N,N-Dimethyl-2-(((1R,2S,4R)-1,7,7-trimethyl-2-phenylbicyclo[2.2.1]heptan-2-yl)oxy)ethanamine;N,N-dimethyl-2-[[(1R,3S,4R)-4,7,7-trimethyl-3-phenyl-3-bicyclo[2.2.1]heptanyl]oxy]ethanamine;Ethanamine, N,N-dimethyl-2-[[(1R,2S,4R)-1,7,7-trimethyl-2-phenylbicyclo[2.2.1]hept-2-yl]oxy]-
中文名:
德倫環(huán)烷
中文別名:
德倫環(huán)烷;化合物 T10996;化合物 DERAMCICLANE;N,N-二甲基-2-(((1R,2S,4R)-1,7,7-三甲基-2-苯基雙環(huán)[2.2.1]庚-2-基)氧基)乙烷-1-胺
CBNumber:
CB2818661
分子式:
C20H31NO
分子量:
301.47
MOL File:
120444-71-5.mol

德倫環(huán)烷化學(xué)性質(zhì)

沸點:
375.2±25.0 °C(Predicted)
密度:
1.01±0.1 g/cm3(Predicted)
儲存條件:
Store at -20°C
溶解度:
Soluble in DMSO
酸度系數(shù)(pKa):
pKa 9.61±0.03(H2O t=25±0.1 I=0.1(NaCl)) (Uncertain)
形態(tài):
Oil
顏色:
Light yellow to yellow
安全信息

德倫環(huán)烷性質(zhì)、用途與生產(chǎn)工藝

生物活性

Deramciclane 對 5-HT2A 和 5-HT2C 受體具有高親和力。Deramciclane 作為兩種受體亞型的拮抗劑，對 5-HT2C 受體具有反向激動劑特性，無直接刺激激動劑。

靶點

5-HT 2A Receptor

5-HT 2C Receptor

體外研究

Deramciclane is a novel anxiolytic agent that binds with high affinity to 5-HT 2A / 2C receptors. The interactions of Deramciclane with the serotonin 5-HT 2C receptor are characterized further using receptor phosphoinositide hydrolysis assays and receptor autoradiography. Deramciclane antagonizes 5-HT 2C receptor mediated 5-HT-stimulated phosphoinositide hydrolysis with an IC 50 value of 168 nM. Deramciclane also decreases basal phosphoinositide hydrolysis by up to 33% (EC 50 = 93 nM) in a physiological system in the choroid plexus, suggesting that Deramciclane possesses inverse agonist properties at this receptor.

體內(nèi)研究

Deramciclane 3 and 10 mg/kg does not change the dopamine levels significantly at any time point versus the basal level whereas 30 mg/kg of Deramciclane significantly increases the levels at 40-100 min and at 160-240 min (P<0.05). Deramciclane is a putative antiserotonergic compound that reduces 5-HT-induced phosphoinositol hydrolysis and a variety of actions caused by serotonergic agonists. The receptor binding profile of Deramciclane is rather similar to that of ritanserin. Deramciclane has a high affinity for 5-HT 2A and 5-HT 2C receptors; it acts as an antagonist at both receptor subtypes and has inverse agonist properties at the 5-HT 2C receptors without direct stimulatory agonist effects. Deramciclane has been shown to have anxiolytic-like activity in several animal tests.

德倫環(huán)烷 上下游產(chǎn)品信息

上游原料

下游產(chǎn)品

德倫環(huán)烷 試劑級價格

更新日期產(chǎn)品編號產(chǎn)品名稱CAS編號包裝價格
2025/02/08HY-101630德倫環(huán)烷
Deramciclane		120444-71-51 mg1590元
2025/02/08HY-101630德倫環(huán)烷
Deramciclane		120444-71-55mg3500元

德倫環(huán)烷 生產(chǎn)廠家

全球有 24家供應(yīng)商   德倫環(huán)烷國內(nèi)生產(chǎn)廠家
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上海偕騰生物科技有限公司 +86-021-58975553 sales@cooperpharm.com 中國 1210 56
上海創(chuàng)焰化學(xué)科技有限公司 021-11111111 11111111111 546919421@qq.com 中國 3275 55
范德(北京)生物科技有限責(zé)任公司 15911056312 liming@bio-fount.com 中國 9729 58
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 marketing@targetmol.com 美國 32161 58
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成都超九八生物科技有限公司 13348960310 13348960310 3003867561@qq.com 中國 10524 58
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120444-71-5, 德倫環(huán)烷 相關(guān)搜索:

  • 抑制劑
  • 化合物 DERAMCICLANE
  • N,N-二甲基-2-(((1R,2S,4R)-1,7,7-三甲基-2-苯基雙環(huán)[2.2.1]庚-2-基)氧基)乙烷-1-胺
  • 化合物 T10996
  • 德倫環(huán)烷
  • 120444-71-5
  • DERAMCICLANE ISO 9001：2015 REACH
  • N,N-dimethyl-2-[[(1R,3S,4R)-4,7,7-trimethyl-3-phenyl-3-bicyclo[2.2.1]heptanyl]oxy]ethanamine
  • Ethanamine, N,N-dimethyl-2-[[(1R,2S,4R)-1,7,7-trimethyl-2-phenylbicyclo[2.2.1]hept-2-yl]oxy]-
  • EGIS-3886
  • N,N-Dimethyl-2-(((1R,2S,4R)-1,7,7-trimethyl-2-phenylbicyclo[2.2.1]heptan-2-yl)oxy)ethanamine
  • N,N-Dimethyl-2-[[(1R,2S,4R)-1,7,7-trimethyl-2-phenylbicyclo[2.2.1]hept-2-yl]oxy]ethanamine
  • N,N-dimethyl-2-(((1S,2S,4R)-1,7,7-trimethyl-2-phenylbicyclo[2.2.1]heptan-2-yl)oxy)ethanamine
  • DERAMCLCLANE
  • DERAMCICLANE
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