STF 083010
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- CAS號(hào):
- 307543-71-1
- 英文名:
- STF 083010
- 英文別名:
- CS-2901;CS-2595;STF 083010;STF-083010;STF083010;STF 083010;N-[(2-Hydroxy-1-naphthalenyl)methylene]-2-thiophenesulfonamide;N-((2-Hydroxynaphthalen-1-yl)methylene)thiophene-2-sulfonamide;2-Thiophenesulfonamide, N-[(2-hydroxy-1-naphthalenyl)methylene]-;(E)-N-((2-hydroxynaphthalen-1-yl)methylene)thiophene-2-sulfonamide;STF 083010,STF-083010,Inositol requiring enzyme 1,Inhibitor,inhibit,IRE1
- 中文名:
- STF 083010
- 中文別名:
- STF-083010游離態(tài);英文名稱:STF 083010;IRE1抑制劑(STF-083010);N-((2-羥基萘-1-基)亞甲基)噻吩-2-磺酰胺;N-[(2-羥基-1-萘基)亞甲基]-2-噻吩磺酰胺
- CBNumber:
- CB22701433
- 分子式:
- C15H11NO3S2
- 分子量:
- 317.38
- MOL File:
- 307543-71-1.mol
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STF 083010化學(xué)性質(zhì)
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熔點(diǎn):
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199-201°C
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沸點(diǎn):
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548.4±56.0 °C(Predicted)
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密度:
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1.40±0.1 g/cm3(Predicted)
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儲(chǔ)存條件:
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-20°C
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溶解度:
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DMSO: soluble5mg/mL (clear solution)
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酸度系數(shù)(pKa):
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7.31±0.50(Predicted)
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形態(tài):
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powder
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顏色:
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light yellow to yellow-green
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穩(wěn)定性:
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Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
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STF 083010性質(zhì)、用途與生產(chǎn)工藝
STF-083010 是一種 IRE1α 特異性抑制劑。在內(nèi)質(zhì)網(wǎng)應(yīng)激后，STF-083010 抑制 Ire1 內(nèi)切核酸酶活性，而不影響其激酶活性。
STF-083010 shows cytostatic and cytotoxic activity in a dose- and time-dependent manner. Treatment with STF-083010 shows significant antimyeloma activity in model human multiple myeloma (MM) xenografts. RPMI 8226 human MM cells grown as tumor xenografts are treated in NSG mice. Intraperitoneal injection of STF-083010 alone (day 1, day 8) significantly inhibits the growth of these tumors. STF-083010 is an IRE1α-specific inhibitor. Four pancreatic cancer cell lines (Panc0403, Panc1005, BxPc3, MiaPaCa2) are treated with different combination of Bortezomib (10 or 50 nM) and STF (10 or 50 μM). The normalized isobologram analysis demonstrates synergistic activity between 10 μM STF and either 10 or 50 nM bortezomib in all four cell lines. Moreover, a higher concentration of STF (50 μM) attains synergy after addition of bortezomib either at a concentration of 10 nM when tested against BxPc3 cells, at a concentration of 50 nM against Panc1005 cells, and at either 10 or 50 nM against Panc0403 cells. STF-083010 (50 μM) suppresses the growth of p53-deficient human cancer cells.
Treatment with STF-083010 reduces the viability of HCT116
p53
-/-
cells by approximately 20% compared with that of HCT116
p53
-/-
cells. Administration of STF-083010 to tumors induced by HCT116
p53
-/-
cells significantly reduces tumor volume and weight by 75% and 73% at the endpoint, respectively.
STF 083010
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS編號(hào) | 包裝 | 價(jià)格 |
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| 2024/11/08 | HY-15845 | STF-083010 | | 1 mg | 250元 |
| 2024/11/08 | HY-15845 | STF 083010
STF-083010 | 307543-71-1 | 5mg | 550元 |
307543-71-1, STF 083010 相關(guān)搜索:
- Inhibitors
- 抑制劑
- 天然產(chǎn)物
- 化工
- 細(xì)胞生物學(xué)試劑
- 小分子抑制劑，天然產(chǎn)物
- N-((2-羥基萘-1-基)亞甲基)噻吩-2-磺酰胺
- 英文名稱:STF 083010
- STF-083010游離態(tài)
- N-[(2-羥基-1-萘基)亞甲基]-2-噻吩磺酰胺
- IRE1抑制劑(STF-083010)
- 307543-71-1
- STF 083010,STF-083010,Inositol requiring enzyme 1,Inhibitor,inhibit,IRE1
- N-((2-Hydroxynaphthalen-1-yl)methylene)thiophene-2-sulfonamide
- 2-Thiophenesulfonamide, N-[(2-hydroxy-1-naphthalenyl)methylene]-
- CS-2901
- CS-2595
- STF-083010;STF083010;STF 083010
- N-[(2-Hydroxy-1-naphthalenyl)methylene]-2-thiophenesulfonamide
- (E)-N-((2-hydroxynaphthalen-1-yl)methylene)thiophene-2-sulfonamide
- STF 083010