980-71-2
中文名稱
馬來酸溴苯那敏
英文名稱
Brompheniramine hydrogen maleate
CAS
980-71-2
EINECS 編號
213-562-9
分子式
C20H23BrN2O4
MDL 編號
MFCD00057367
分子量
435.31
MOL 文件
980-71-2.mol
更新日期
2023/03/20 15:41:21
980-71-2 結(jié)構(gòu)式
基本信息
中文別名
N,N-二甲基-gamma-(4-溴苯基)-2-吡啶丙胺順丁烯二酸鹽馬來酸溴苯那敏
溴苯那敏
英文別名
1-(n,n-dimethylamino)-3-(p-bromophenyl)-3-(alpha-pyridyl)propane maleate1-p-bromophenyl-1-(2-pyridyl)-3-dimethylaminopropane maleate
BROMOPHENIRAMINE MALEATE
brompheniramine hydrogen maleate
BROMPHENIRAMINE MALEATE
(+/-)-BROMPHENIRAMINE MALEATE SALT
BROMPHENIRAMINE MALEATE SALT
2-(p-bromo-alpha-(2-(dimethylamino)ethyl)benzyl)pyridinemaleate(1:1)
2-(p-bromo-alpha-(2-(dimethylamino)ethyl)benzyl)-pyridinmaleate(1:1)
dimegan
dimetane
dimetanemaleate
dimotane
g-(4-bromophenyl)-N,N-dimethyl-2-pyridinepropanaminemaleate
gamma-(4-bromophenyl)-n,n-dimethyl-2-pyridinepropanamin(z)-2-butenedioate
gamma-(4-bromophenyl)-n,n-dimethyl-2-pyridinepropanamin(z)-butenedioate
ilvinmaleate
parabromdylaminemaleate
parabromodylaminemaleate
γ-(4-bromophenyl)-N,N-dimethyl-2-pyridinepropanaminemaleate
所屬類別
原料藥：抗組胺藥物理化學(xué)性質(zhì)
熔點134-135°C
閃點9℃
儲存條件Inert atmosphere,Room Temperature
溶解度Soluble in water, freely soluble in ethanol (96 per cent), in methanol and in methylene chloride.
形態(tài)neat
顏色白色至灰白色
最大波長(λmax)261nm(lit.)
Merck14,1443
穩(wěn)定性吸濕性
InChIKeySRGKFVAASLQVBO-BTJKTKAUSA-N
LogP3.565 (est)
CAS 數(shù)據(jù)庫980-71-2(CAS DataBase Reference)
980-71-2(安全特性,毒性,儲運)
儲運特性
庫房通風(fēng)低溫干燥; 與食品原料類分開存放毒性分級
高毒急性毒性
口服-大鼠 LD50: 318 毫克/公斤; 腹腔-大鼠 LD50: 76 毫克/公斤可燃性危險特性
熱分解排出有毒氮氧化物和溴化物,氯化氫煙霧類別
有毒物質(zhì)滅火劑
水,干粉、干砂、二氧化碳、泡沫、1211滅火劑馬來酸溴苯那敏價格(試劑級)
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2024/11/08 | HY-B0480 | 馬來酸溴苯那敏 Brompheniramine maleate | 980-71-2 | 50mg | 714元 |
| 2024/11/08 | HY-B0480 | 馬來酸溴苯那敏 Brompheniramine maleate | 980-71-2 | 10mM * 1mLin DMSO | 785元 |
| 2024/11/08 | S2585 | 馬來酸溴苯那敏 Brompheniramine hydrogen maleate | 980-71-2 | 50mg | 789.91元 |
常見問題列表
生物活性
Brompheniramine hydrogen maleate是一種組胺H1受體拮抗劑。靶點
| Target | Value |
| Histamine H1 receptor |
體外研究
In in vitro experiments, Brompheniramine blocks muscarinic cholinergic receptors in human chinese hamster ovary (CHO) cells, sodium and calcium channels in CHO cells, as well as potassium channels in human embryonic kidney 293 (HEK-293) cells. Brompheniramine suppresses the transfected Nav 1.5 channels from myocytes.
體內(nèi)研究
Brompheniramine as an antihistamine blocks sodium channels. Brompheniramine (3.0, 1.5, 1.1, 0.6, and 0.3 μmol) treatment shows cutaneous analgesic effect with an ED 50 value of 0.89 in a rat model of infiltration anesthesia. Subcutaneous Brompheniramine induces dose-relatedly analgesic effects, and Brompheniramine induces prolonged analgesic duration.