94079-81-9
中文名稱
金石蠶苷
英文名稱
2-(3,4-Dihydroxyphenyl)ethyl 3-O,6-O-bis(α-L-rhamnopyranosyl)-4-O-[(E)-3-(3,4-dihydroxyphenyl)propenoyl]-β-D-glucopyranoside
CAS
94079-81-9
分子式
C35H46O19
分子量
770.73
MOL 文件
94079-81-9.mol
更新日期
2024/12/25 17:21:41
94079-81-9 結(jié)構(gòu)式
基本信息
中文別名
金石蠶甙金石蠶苷
金石蠶甙對照品,
金石蠶苷(標(biāo)準(zhǔn)品)
金石蠶苷 (金石蠶甙)
金石蠶苷, 來源于廣東紫珠
POLIUMOSIDE 金石蠶苷
英文別名
PoliumosidePoliumoside, 98%, from Callicarpa kwangtungensis Chun
6-(3,4-Dihydroxyphenethoxy)-5-hydroxy-4-((3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)me
2-(3,4-Dihydroxyphenyl)ethyl 3-O,6-O-bis(α-L-rhamnopyranosyl)-4-O-[(E)-3-(3,4-dihydroxyphenyl)propenoyl]-β-D-glucopyranoside
β-D-Glucopyranoside, 2-(3,4-dihydroxyphenyl)ethyl O-6-deoxy-α-L-mannopyranosyl-(1→3)-O-[6-deoxy-α-L-mannopyranosyl-(1→6)]-, 4-[(2E)-3-(3,4-dihydroxyphenyl)-2-propenoate]
O-6-Deoxy-alpha-L-mannopyranosyl-(1-3)-O-[6-deoxy-alpha-L-mannopyranosyl-(1-6)]-beta-D-glucopyranoside 2-(3,4-dihydroxyphenyl)ethyl 4-[3-(3,4-dihydroxyphenyl)-2-propenoate]
[6-[2-(3,4-dihydroxyphenyl)ethoxy]-5-hydroxy-4-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxy-2-[(3,4,5-trihydroxy-6-methyloxan-2-yl)oxymethyl]oxan-3-yl] (E)-3-(3,4-dihydroxyphenyl)prop-2-enoate
所屬類別
生物化工：提取物物理化學(xué)性質(zhì)
外觀性狀類白色結(jié)晶粉末，溶于水，來源于廣東紫珠。
沸點1023.2±65.0 °C(Predicted)
密度1.62
溶解度DMSO : 100 mg/mL (129.75 mM; Need ultrasonic)Ethanol : 50 mg/mL (64.87 mM; Need ultrasonic)
酸度系數(shù)(pKa)9.31±0.10(Predicted)
形態(tài)粉末
顏色白色
常見問題列表
生物活性
Poliumoside對于晚期糖基化終產(chǎn)物的形成有顯著抑制作用，IC50值為19.69 μM。 在大鼠晶狀體醛糖還原酶測定試驗中，發(fā)現(xiàn) Poliumoside對rat lens aldose reductase(RLAR)表現(xiàn)出抑制作用，IC50值為8.47 μM。靶點
| Target | Value |
|
RLAR
() | 8.47 μM |
體外研究
Poliumoside inhibits AGE formation and RLAR, with IC
50
s of 19.69, and 8.47 μM, respectively.
Poliumoside (5-30 μM; 3 h) inhibits AAPH-induced hemolysis of rat red blood cells in vitro.
Poliumoside (12.5-100 μM; pretreated 2 h) inhibits the release of TNF-α and IL-6 in LPS-induced RAW 264.7?cells.
體內(nèi)研究
Poliumoside inhibits vessel dilation in larval zebrafish.