926319-75-7
中文名稱
化合物 T27032
英文名稱
(6-[2-(2-HYDROXY-ETHYLAMINO)-9-ISOPROPYL-9H-PURIN-6-YLAMINO]-HEXYL)-CARBAMIC ACID TERT-BUTYL ESTER
CAS
926319-75-7
分子式
C21H37N7O3
分子量
435.56
MOL 文件
926319-75-7.mol
926319-75-7 結(jié)構(gòu)式
基本信息
中文別名
化合物 T27032 英文別名
CK59CK-59
CK 59
(6-[2-(2-HYDROXY-ETHYLAMINO)-9-ISOPROPYL-9H-PURIN-6-YLAMINO]-HEXYL)-CARBAMIC ACID TERT-BUTYL ESTER
應(yīng)用領(lǐng)域
用途一
CK59 is calcium-calmodulin-dependent kinase II (CaMKII) inhibitor. CK59 inhibits multiple voltage-gated calcium channels, including the L-type channel during depolarization in a dose-dependent manner. The IC50 for CK59 was approximately 50 μM, which is only fivefold larger than the reported IC50 values for CaMKII inhibition. The inhibition due to CK59 was reversible; washout of the drug brought calcium levels back to control values upon depolarization.