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ChemicalBook--->CAS DataBase List--->926319-75-7

926319-75-7

926319-75-7 Structure

926319-75-7 Structure
IdentificationBack Directory
[Name]

(6-[2-(2-HYDROXY-ETHYLAMINO)-9-ISOPROPYL-9H-PURIN-6-YLAMINO]-HEXYL)-CARBAMIC ACID TERT-BUTYL ESTER
[CAS]

926319-75-7
[Synonyms]

CK59
CK-59
CK 59
(6-[2-(2-HYDROXY-ETHYLAMINO)-9-ISOPROPYL-9H-PURIN-6-YLAMINO]-HEXYL)-CARBAMIC ACID TERT-BUTYL ESTER
[Molecular Formula]

C21H37N7O3
[MDL Number]

MFCD11856052
[MOL File]

926319-75-7.mol
[Molecular Weight]

435.56
Hazard InformationBack Directory
[Description]

CK59 is calcium-calmodulin-dependent kinase II (CaMKII) inhibitor. CK59 inhibits multiple voltage-gated calcium channels, including the L-type channel during depolarization in a dose-dependent manner. The IC50 for CK59 was approximately 50 μM, which is only fivefold larger than the reported IC50 values for CaMKII inhibition. The inhibition due to CK59 was reversible; washout of the drug brought calcium levels back to control values upon depolarization.
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