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924636-93-1

英文名稱 Benzamide, N-(9-ethyl-9H-carbazol-3-yl)-2-(trifluoromethyl)-
CAS 924636-93-1
分子式 C22H17F3N2O
分子量 382.38
MOL 文件 924636-93-1.mol
924636-93-1 結(jié)構(gòu)式 924636-93-1 結(jié)構(gòu)式

基本信息

英文別名
Benzamide, N-(9-ethyl-9H-carbazol-3-yl)-2-(trifluoromethyl)-

應(yīng)用領(lǐng)域

用途一
AF3442 is a potent and selective mPGES-1 inhibitor (microsomal prostaglandin (PG) E synthase-1). AF3442 caused a concentration-dependent inhibition of PGE(2) in human recombinant mPGES-1 with an IC(50) of 0.06microM. AF3442 is a selective mPGES-1 inhibitor which reduced monocyte PGE(2) generation also in the presence of plasma proteins. Pharmacological inhibition of mPGES-1 did not translate into redirection of PGH(2) metabolism towards other terminal PG synthases in monocytes. The functional relevance of this observation deserves to be investigated in vivo.
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